{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:04:47Z","timestamp":1789499087818,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014599","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000}}],"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bangladesh experienced a notable resurgence of chikungunya cases in 2025, following its last major outbreak in 2017. This study aimed to characterize the epidemiological profile of laboratory-confirmed chikungunya cases in Bangladesh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included and interviewed 442 laboratory-confirmed adult chikungunya cases. Pain was assessed using the Visual Analog Scale (VAS, 0\u201310) and quality of life was measured via the validated Bangla EQ-5D-3 L instrument, which evaluates five domains\u2014mobility, self-care, usual activities, pain\/discomfort, and anxiety\/depression. Overall health was rated using the EQ-VAS, a vertical scale ranging from 0 (\u201cworst imaginable health state\u201d) to 100 (\u201cbest imaginable health state\u201d). Index scores were derived using the trade-off (TTO) valuation set. Associations with the overall EQ-5D index were analyzed using Tobit regression, whereas domain-specific associations were examined via ordinal logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of all, 16.5% of patients required hospital admission, with a median length of stay of 5 days (IQR 3\u20136), and the rest of them consulted on an outdoor basis. The mean (SD) age of the participants was 45\u00b73 (15\u00b75) years, and 60% were female. Fever (98%) and arthralgia (97%) were the predominant symptoms. Mild pain was reported by 6% of patients, while 40% had moderate and 54% had severe pain, with a median VAS score of 8.0 (IQR 7.0\u20139.0). Over 70% of the participants reported mobility limitations, self-care, functional impairment, pain or psychological symptoms. The median EQ-5D index was 0\u00b778 (IQR 0\u00b760-0\u00b796). Female sex (\u03b2\u2009=\u2009\u20130\u00b710, 95% CI \u20130\u00b717, \u20130\u00b702) and greater pain severity (\u03b2\u2009=\u2009\u20130\u00b726, 95% CI \u20130\u00b737, \u20130\u00b715) were independently associated with a lower EQ-5D index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During the outbreak, chikungunya patients in Bangladesh predominantly presented with fever and joint pain and experienced marked declines in quality of life, with women being disproportionately affected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014599","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:45:32Z","timestamp":1787766332000},"page":"e0014599","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute-phase clinical profile and quality of life in patients with chikungunya during the 2025 outbreak in Bangladesh: A facility-based cross-sectional study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-1739","authenticated-orcid":true,"given":"Mohammad Jahid","family":"Hasan","sequence":"first","affiliation":[{"name":"Tropical Disease and Health Research Center","place":["Dhaka, Bangladesh"],"department":["Department of Public Health"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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Hamidullah","family":"Mehedi","sequence":"additional","affiliation":[{"name":"250 Bedded General Hospital","place":["Chattogram, Bangladesh"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Saif Mohammad Lutful","family":"Kabir","sequence":"additional","affiliation":[{"name":"250 Bedded General Hospital","place":["Chattogram, Bangladesh"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannatul","family":"Fardous","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health (NIMH)","place":["Dhaka, Bangladesh"],"department":["Department of Psychiatry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refaya","family":"Tasnim","sequence":"additional","affiliation":[{"name":"BRB Hospitals Limited","place":["Dhaka, Bangladesh"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Popular Medical College Hospital","place":["Dhaka, Bangladesh"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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