{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:16:57Z","timestamp":1787941017843,"version":"build-2784847793"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["226688\/F\/22\/Z"],"award-info":[{"award-number":["226688\/F\/22\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI162907"],"award-info":[{"award-number":["R01AI162907"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD094955"],"award-info":[{"award-number":["R01HD094955"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006258","name":"Comisi\u00f3n de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["2020-00862"],"award-info":[{"award-number":["2020-00862"]}],"id":[{"id":"10.13039\/501100006258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013996","name":"Global Health Innovative Technology Fund","doi-asserted-by":"publisher","award":["2025-121"],"award-info":[{"award-number":["2025-121"]}],"id":[{"id":"10.13039\/501100013996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    The transplacental route is the main human-to-human transmission mode of\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    infection, causing congenital Chagas disease, a major health problem in most endemic and nonendemic areas. The prevention, diagnosis, and follow-up of pregnant women and congenitally infected newborns face limitations, such as regional variations of concordance among serological tests used to diagnose\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    infection in the Americas, the low sensitivity of microscopic examination for detecting live trypomastigotes in blood, and losses of infected women and newborns in screening and follow-up programs. In addition, fetal growth retardation was recently documented in uninfected newborns of infected mothers. The potential practical impacts of some new approaches, based on fundamental concepts and results of clinical observations addressing\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    infection in pregnancy, such as simplifying the serodiagnosis, detecting and identifying live\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    clones and monitoring fetal growth retardation in all neonates of infected mothers, are discussed as open research questions.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014665","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:24:12Z","timestamp":1787937852000},"page":"e0014665","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trypanosoma cruzi infection in pregnancy: New approaches to address the diagnosis and follow-up of women and newborns"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0199-6818","authenticated-orcid":true,"given":"Yves","family":"Carlier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-0668","authenticated-orcid":true,"given":"Jackeline","family":"Alger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dumonteil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro G.","family":"Schijman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Buekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"1","key":"pntd.0014665.ref001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/1471-0528.12396","article-title":"Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis","volume":"121","author":"EJ Howard","year":"2014","journal-title":"BJOG"},{"issue":"11","key":"pntd.0014665.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010376","article-title":"Estimation of the morbidity and mortality of congenital Chagas disease: a systematic review and meta-analysis","volume":"16","author":"S Matthews","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014665.ref003","first-page":"100821","article-title":"Retrospect, advances and challenges in Chagas disease diagnosis: a comprehensive review","volume":"36","author":"AG Schijman","year":"2024","journal-title":"Lancet Reg Health Am"},{"issue":"9","key":"pntd.0014665.ref004","article-title":"Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: a meta-analysis of observational studies","volume":"18","author":"de Moraes FCA","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0014665.ref005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007694","article-title":"Congenital Chagas disease: updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women","volume":"13","author":"Y Carlier","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014665.ref006","unstructured":"Pan American Health Organization (PAHO). 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