{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:22Z","timestamp":1789063762932,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014691","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000}}],"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215604\/Z\/19\/Z"],"award-info":[{"award-number":["215604\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["K01TW012177"],"award-info":[{"award-number":["K01TW012177"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005624","name":"PATH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Enteric fever, caused by\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      serovars Typhi and Paratyphi, remains an important cause of febrile illness in low- and middle-income countries (LMIC). However, the exact burden is difficult to estimate due to limitations in diagnosis and surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Samples from a representative cross-sectional household serosurvey in rural western Cambodia were used to estimate enteric fever seroincidence among children and young adults. Participants were enrolled between April 7 and December 10, 2023, and 529 samples from individuals aged 5\u201325 years were analysed. Using IgA and IgG responses to hemolysin E antigen and established models of antibody decay after infection, we estimated seroincidence, conveying the rate of new infection in the population over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall enteric fever seroincidence rate was 161.8\/1,000 person-years (95%CI: 147.5, 177.5). Among children 5\u201315 years, it ranged between 149.5 (95%CI: 120.8, 185.1) and 239.0 (95%CI:188.7, 302.7) across districts. Seroincidence was higher among children 5\u201315 years from households with unimproved drinking water sources or sanitation facilities, and in districts with a higher proportion of households with unimproved WASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings potentially support the introduction of the typhoid conjugate vaccine in rural western Cambodia. However, additional data on the relative contribution of\n                      <jats:italic>S.<\/jats:italic>\n                      Typhi versus\n                      <jats:italic>S.<\/jats:italic>\n                      Paratyphi is needed. We also demonstrate seroincidence as an adjunctive valuable surveillance tool in LMICs where facility-based surveillance may be inadequate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014691","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:44:01Z","timestamp":1788371041000},"page":"e0014691","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimating enteric fever seroincidence in rural western Cambodia: Findings from a population-based cross-sectional serosurvey"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-8379","authenticated-orcid":true,"given":"Meiwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Mahidol University","place":["Bangkok, Thailand"],"department":["Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical 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