{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:06:44Z","timestamp":1789153604636,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014692","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000}}],"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5R01-HD096741"],"award-info":[{"award-number":["5R01-HD096741"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Zika virus (ZIKV) is an arthropod-borne\n                    <jats:italic>Orthoflavivirus<\/jats:italic>\n                    that caused a major outbreak in Central and South America in 2015\u201316. During that outbreak, ZIKV infection during pregnancy was associated with high rates of adverse outcomes, including miscarriage and a spectrum of neurological birth defects collectively termed congenital Zika syndrome (CZS). Ten years later, there are still no licensed ZIKV vaccines, underscoring the need for robust experimental models to evaluate vaccine efficacy against congenital disease. Here, we evaluated a highly pathogenic nonhuman primate pregnancy model for its ability to assess vaccine-mediated protection using a Zika virus-like particle (VLP) vaccine as a test platform. First, non-pregnant rhesus macaques (RM) were vaccinated with a prime-boost method to compare control, VLP alone, and VLP plus Alhydrogel (alum) adjuvant. Vaccination plus alum elicited strong neutralizing antibody responses and reduced viral dissemination compared to controls. Next, we evaluated the vaccine\u2019s protective efficacy against adverse pregnancy complications. Two cohorts of female RM were vaccinated with ZIKV-VLP adjuvanted with alum or alum alone prior to time-mated breeding. At gestational day (GD) 30 (mid first trimester), pregnant animals were challenged with ZIKV-DAK 41524, an African-lineage strain previously shown to induce frequent first-trimester pregnancy loss. Within the vaccinated cohort, two of three animals reached the study endpoint of GD 90 with no observed adverse pregnancy outcomes. One vaccinated animal experienced early pregnancy loss despite the absence of detectable virus in fetal or placental tissues. In the sham vaccine control pregnancy cohort, severe adverse outcomes included miscarriage and hydrops fetalis with widespread viral RNA and placental pathology in two animals. These results support a high risk of early pregnancy loss following African-lineage ZIKV-DAK 41524 infection in RM. This model can be further used to understand the complexities of placental immunological features underlying miscarriage following ZIKV infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014692","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:47:32Z","timestamp":1788889652000},"page":"e0014692","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection"],"prefix":"10.1371","volume":"20","author":[{"given":"Hannah K.","family":"Jaeger","sequence":"first","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caralyn S.","family":"Labriola","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia J.","family":"Pung","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia L.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Denton","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul J.","family":"D\u2019Mello","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Portland, Oregon, United States of America"],"department":["Department of Obstetrics & Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Parkins","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney C.","family":"Weber","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Medica","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig N.","family":"Kreklywich","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"DeFilippis","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bondoc","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Busman-Sahay","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna N.","family":"Castro","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Zilverberg","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riely","family":"White","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Terry","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Barber-Axthelm","sequence":"additional","affiliation":[{"name":"Oregon Health & Science 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Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Aliota","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["St. Paul, Minnesota, United States of America"],"department":["Department of Veterinary and Biomedical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Weiler","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Wisconsin National Primate Research Center, University of Wisconsin-Madison","place":["Madison, Wisconsin, United States of America"],"department":["Department of Pathobiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Wisconsin National Primate Research Center, University of Wisconsin-Madison","place":["Madison, Wisconsin, United States of America"],"department":["Department of Pathobiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Estes","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry K.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Portland, Oregon, United States of America"],"department":["Department of Obstetrics & Gynecology"]},{"name":"Oregon Health & Science University","place":["Portland, Oregon, United States of America"],"department":["Department of Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie O.","family":"Lo","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center"]},{"name":"Oregon Health & Science University","place":["Portland, Oregon, United States of America"],"department":["Department of Obstetrics & Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H. J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N.","family":"Streblow","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8613-0740","authenticated-orcid":true,"given":"Alec J.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"The Vaccine & Gene Therapy Institute, Oregon Health and Science University","place":["Beaverton, Oregon, United States of America"]},{"name":"Oregon Health & Science University","place":["Beaverton, Oregon, United States of America"],"department":["Division of Pathobiology & Immunology, Oregon National Primate Research Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"24","key":"pntd.0014692.ref001","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"P Brasil","year":"2016","journal-title":"N Engl J Med"},{"issue":"12","key":"pntd.0014692.ref002","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jamaneurol.2016.3720","article-title":"Congenital Zika Virus infection: beyond neonatal microcephaly","volume":"73","author":"O Melo AS de","year":"2016","journal-title":"JAMA Neurol"},{"issue":"11","key":"pntd.0014692.ref003","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3201\/eid2211.160956","article-title":"Early growth and neurologic outcomes of infants with probable congenital Zika virus syndrome","volume":"22","author":"AA Moura da Silva","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"15","key":"pntd.0014692.ref004","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJMra1808246","article-title":"Zika virus infection - after the pandemic","volume":"381","author":"D Musso","year":"2019","journal-title":"N Engl J Med"},{"issue":"3","key":"pntd.0014692.ref005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","article-title":"Possible association between Zika virus infection and microcephaly - Brazil, 2015","volume":"65","author":"L Schuler-Faccini","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"pntd.0014692.ref006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1148\/radiol.2016161584","article-title":"Congenital brain abnormalities and Zika virus: what the radiologist can expect to see prenatally and postnatally","volume":"281","author":"P Soares de Oliveira-Szejnfeld","year":"2016","journal-title":"Radiology"},{"issue":"11","key":"pntd.0014692.ref007","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/infdis\/jix204","article-title":"Fetal growth restriction caused by sexual transmission of Zika virus in mice","volume":"215","author":"R Uraki","year":"2017","journal-title":"J Infect Dis"},{"issue":"2","key":"pntd.0014692.ref008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2018.04.047","article-title":"Femur-sparing pattern of abnormal fetal growth in pregnant women from New York City after maternal Zika virus infection","volume":"219","author":"CL Walker","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"pntd.0014692.ref009","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJMc1605898","article-title":"Miscarriage associated with Zika virus infection","volume":"375","author":"AA van der Eijk","year":"2016","journal-title":"N Engl J Med"},{"issue":"7","key":"pntd.0014692.ref010","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3201\/eid2307.162019","article-title":"Postmortem findings for 7 neonates with congenital Zika virus infection","volume":"23","author":"AQ Sousa","year":"2017","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"pntd.0014692.ref011","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tim.2016.05.002","article-title":"Zika virus: two or three lineages?","volume":"24","author":"Z Gong","year":"2016","journal-title":"Trends Microbiol"},{"issue":"2","key":"pntd.0014692.ref012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001477","article-title":"Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage","volume":"6","author":"AD Haddow","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"pntd.0014692.ref013","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid2205.160065","article-title":"Phylogeny of Zika virus in western hemisphere, 2015","volume":"22","author":"RS Lanciotti","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"6283","key":"pntd.0014692.ref014","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: early epidemiological and genetic findings","volume":"352","author":"NR Faria","year":"2016","journal-title":"Science"},{"issue":"3","key":"pntd.0014692.ref015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians","volume":"171","author":"CA Moore","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"7","key":"pntd.0014692.ref016","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1590\/0004-282x20200020","article-title":"Clinical characteristics of children with congenital Zika syndrome: a case series","volume":"78","author":"T Massetti","year":"2020","journal-title":"Arq Neuropsiquiatr"},{"key":"pntd.0014692.ref017","doi-asserted-by":"crossref","first-page":"680342","DOI":"10.3389\/fgene.2021.680342","article-title":"Non-human primate models to investigate mechanisms of infection-associated fetal and pediatric injury, teratogenesis and stillbirth","volume":"12","author":"M Li","year":"2021","journal-title":"Front Genet"},{"issue":"6","key":"pntd.0014692.ref018","doi-asserted-by":"crossref","first-page":"101030","DOI":"10.1016\/j.lanmic.2024.101030","article-title":"Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection","volume":"6","author":"A Li","year":"2025","journal-title":"Lancet Microbe"},{"issue":"1","key":"pntd.0014692.ref019","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1293\/tox.2013-0060","article-title":"A comparison of the histological structure of the placenta in experimental animals","volume":"27","author":"S Furukawa","year":"2014","journal-title":"J Toxicol Pathol"},{"issue":"1","key":"pntd.0014692.ref020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-0035-1570031","article-title":"Animal models to study placental development and function throughout normal and dysfunctional human pregnancy","volume":"34","author":"PL Grigsby","year":"2016","journal-title":"Semin Reprod Med"},{"key":"pntd.0014692.ref021","article-title":"The macaque placenta\u2014a mini-review","volume":"36","author":"EPCT de Rijk","year":"2008","journal-title":"Toxicol Pathol"},{"issue":"5","key":"pntd.0014692.ref022","first-page":"491","article-title":"Translational utility of the nonhuman primate model","volume":"7","author":"AF Tarantal","year":"2022","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"8","key":"pntd.0014692.ref023","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41591-018-0088-5","article-title":"Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates","volume":"24","author":"DM Dudley","year":"2018","journal-title":"Nat Med"},{"issue":"3","key":"pntd.0014692.ref024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011282","article-title":"Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus","volume":"19","author":"JR Rosinski","year":"2023","journal-title":"PLoS Pathog"},{"issue":"5","key":"pntd.0014692.ref025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/v10050229","article-title":"Comparative pathogenesis of Asian and African-lineage Zika virus in Indian rhesus macaque\u2019s and development of a non-human primate model suitable for the evaluation of new drugs and vaccines","volume":"10","author":"JO Rayner","year":"2018","journal-title":"Viruses"},{"issue":"8","key":"pntd.0014692.ref026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011274","article-title":"Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model","volume":"19","author":"MR Koenig","year":"2023","journal-title":"PLoS Pathog"},{"issue":"7","key":"pntd.0014692.ref027","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00750-3","article-title":"Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development","volume":"25","author":"JT Ostrowsky","year":"2025","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"pntd.0014692.ref028","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1708120","article-title":"Safety and immunogenicity of an anti-Zika virus DNA vaccine","volume":"385","author":"P Tebas","year":"2021","journal-title":"N Engl J Med"},{"issue":"9","key":"pntd.0014692.ref029","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1473-3099(20)30085-2","article-title":"Safety and immunogenicity of a Zika purified inactivated virus vaccine given via standard, accelerated, or shortened schedules: a single-centre, double-blind, sequential-group, randomised, placebo-controlled, phase 1 trial","volume":"20","author":"KE Stephenson","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"pntd.0014692.ref030","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7326\/M20-5306","article-title":"A double-blind, randomized, placebo-controlled phase 1 study of Ad26.ZIKV.001, an Ad26-vectored anti-Zika virus vaccine","volume":"174","author":"NC Salisch","year":"2021","journal-title":"Ann Intern Med"},{"issue":"10120","key":"pntd.0014692.ref031","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(17)33105-7","article-title":"Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials","volume":"391","author":"MR Gaudinski","year":"2018","journal-title":"Lancet"},{"key":"pntd.0014692.ref032","doi-asserted-by":"crossref","first-page":"104375","DOI":"10.1016\/j.ebiom.2022.104375","article-title":"Safety and immunogenicity of AGS-v PLUS, a mosquito saliva peptide vaccine against arboviral diseases: a randomized, double-blind, placebo-controlled Phase 1 trial","volume":"86","author":"DJ Friedman-Klabanoff","year":"2022","journal-title":"EBioMedicine"},{"issue":"5","key":"pntd.0014692.ref033","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1473-3099(22)00764-2","article-title":"The safety and immunogenicity of two Zika virus mRNA vaccine candidates in healthy flavivirus baseline seropositive and seronegative adults: the results of two randomised, placebo-controlled, dose-ranging, phase 1 clinical trials","volume":"23","author":"B Essink","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"pntd.0014692.ref034","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/infdis\/jiac482","article-title":"Persistence of immunogenicity of a purified inactivated Zika virus vaccine candidate in healthy adults: 2 years of follow-up compared with natural infection","volume":"227","author":"CJ Acosta","year":"2023","journal-title":"J Infect Dis"},{"key":"pntd.0014692.ref035","author":"FierceBiotech","year":"2024"},{"key":"pntd.0014692.ref036","author":"Organization PAH.","year":"2023"},{"key":"pntd.0014692.ref037","year":"2021"},{"issue":"1","key":"pntd.0014692.ref038","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/vaccines8010124","article-title":"Safety of administering live vaccines during pregnancy: a systematic review and meta-analysis of pregnancy outcomes","volume":"8","author":"A Laris-Gonz\u00e1lez","year":"2020","journal-title":"Vaccines (Basel)"},{"issue":"1","key":"pntd.0014692.ref039","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/CVI.00369-09","article-title":"Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination","volume":"17","author":"ML Silva","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"3","key":"pntd.0014692.ref040","first-page":"224","article-title":"Viremia in a recipient of HPV-77 Rubella virus vaccine","volume":"110","author":"J Wilkins","year":"1969","journal-title":"Calif Med"},{"issue":"7","key":"pntd.0014692.ref041","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/infdis\/jix314","article-title":"Replication and excretion of the live attenuated tetravalent dengue vaccine CYD-TDV in a flavivirus-naive adult population: 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