{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:43Z","timestamp":1792788523249,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014704","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI141712"],"award-info":[{"award-number":["R01AI141712"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MSD Animal Health","id":[{"id":"https:\/\/ror.org\/024409k12","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["207569\/Z\/17\/Z"],"award-info":[{"award-number":["207569\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["224520\/Z\/21\/Z"],"award-info":[{"award-number":["224520\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 60,000 people die from rabies annually, mostly in Africa and Asia. Mass dog vaccination is critical for elimination. Herd immunity has been calculated to be attained when &gt;40% (critical threshold) of dogs are vaccinated. A common delivery method implemented in Tanzania and other countries typically involves non-local teams travelling to villages implementing dog vaccination annually through static-point clinics using cold chain stored vaccines (Team-based delivery). Determination that a canine rabies vaccine is thermotolerant enables novel Community-based dog vaccination strategies whereby community vaccinators use vaccines stored locally throughout the year (Community-based delivery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two dog vaccination strategies were compared using a three-year cluster randomized controlled trial in Tanzania (Clinical Trials Registration Number ISRCTN14813279). The strategies were designed to represent implementation using resources typical of government-led initiatives. Wards (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009112) were randomly assigned to either Team-based delivery or Community-based delivery. Coverage was estimated using household surveys implemented biannually.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Mean coverage achieved by Community-based delivery (55%; 95% Confidence Interval (CI): 45\u201365%) was higher than Team-based delivery (37%; 95% CI: 28\u201346%). Moreover, because coverage was lower and declined over each year only in Team-based delivery, the probability of coverage being below the critical threshold was higher for Team-based delivery (60%) compared to Community-based delivery (18%). To ensure coverage does not dip below the critical threshold by the year end, coverage at the start of the year in Team-based delivery needed to be higher (61%) than in Community-based (42%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Community-based delivery achieved higher and more consistent vaccination coverage across a range of settings typical of many sub-Saharan African countries. Generalisation to different sociocultural\/ agroecological settings requires further evidence. Although direct evidence on impact on rabies elimination was not measured, this approach could play a role in national elimination strategies, developed for the global \u2018Zero by 30\u2019 strategy to end dog-mediated rabies deaths by 2030, and in response to investment by Gavi, the vaccine alliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014704","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:01:51Z","timestamp":1790366511000},"page":"e0014704","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of community-based delivery of mass dog vaccination to prevent rabies: A cluster randomized controlled trial"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-0693","authenticated-orcid":true,"given":"Felix","family":"Lankester","sequence":"first","affiliation":[{"name":"Washington State University","place":["Pullman, Washington, United States of America"],"department":["Paul G. 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