{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:51:59Z","timestamp":1791571919752,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014742","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102692"],"award-info":[{"award-number":["32102692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Through systematic structural optimization and modification of anti-\n                    <jats:italic>Cryptosporidium parvum<\/jats:italic>\n                    compound NSC158011 (N-1-naphthalenyl-2-(phenylthiol) ethane thioamide), we constructed a virtual compound library comprising 1,440 derivatives, and 29 derivatives were selected via molecular docking for chemical synthesis. Among them, eight derivatives exhibited significant inhibitory effects on LDH compared with NSC158011. In vitro examination found that two derivatives could markedly reduce the number of\n                    <jats:italic>C. parvum<\/jats:italic>\n                    in cells while exhibiting reduced toxicity. In vivo studies in model animals (IFN-\u03b3 knockout mouse) and native animals (calves) further validated the derivatives\u2019 potent anti-parasitic effects and their ability to alleviate intestinal villus atrophy caused by parasitic infections. Further investigations revealed that compound treatment was associated with upregulated expression of intestinal tight junction proteins (ZO-1, Occludin, Claudin-1) and downregulated the expression level of inflammatory protein Caspase-1. Analysis of the gut microbiota and metabolomics in calves indicated that treatment significantly restored the abundance of beneficial flora and regulated key metabolites, including isocitric acid and ornithine. The two derivatives identified in this study represent promising lead compounds for further development as anti-cryptosporidiosis agents, with potential relevance to livestock production and public health.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014742","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:49:59Z","timestamp":1791222599000},"page":"e0014742","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel inhibitors against Cryptosporidium parvum through blocking its energy metabolism"],"prefix":"10.1371","volume":"20","author":[{"given":"Chang","family":"Xu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Nanjing Agricultural University","place":["Nanjing, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Ji","sequence":"additional","affiliation":[{"name":"College of 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