{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:38:13Z","timestamp":1791268693707,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T00:00:00Z","timestamp":1168992000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0000156","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T21:17:21Z","timestamp":1168982241000},"page":"e156","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":201,"title":["Human Neural Stem Cells Over-Expressing VEGF Provide Neuroprotection, Angiogenesis and Functional Recovery in Mouse Stroke Model"],"prefix":"10.1371","volume":"2","author":[{"given":"Hong J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung U.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage.","volume":"344","author":"AI Qureshi","year":"2001","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10143-002-0222-0","article-title":"What are the actual incidence and mortality rates of intracerebral hemorrhage?","volume":"25","author":"T Inagawa","year":"2002","journal-title":"Neurosurg Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0733-8619(05)70200-0","article-title":"Intracerebral hemorrhage.","volume":"18","author":"JM Gebel","year":"2000","journal-title":"Neurol Clin"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.STR.0000155685.77775.4c","article-title":"Priorities for clinical research in intracerebral hemorrhage: report from a National Institute of Neurological Disorders and Stroke workshop.","volume":"36","year":"2005","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.276.5309.66","article-title":"Stem cells in the central nervous system.","volume":"276","author":"R McKay","year":"1997","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells.","volume":"287","author":"FH Gage","year":"2000","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1038\/nm1064","article-title":"Stem cell therapy for human neurodegenerative disorders.","volume":"10","author":"O Lindvall","year":"2004","journal-title":"Nature Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jnr.20246","article-title":"Human neural stem\/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.","volume":"78","author":"S Ishibashi","year":"2004","journal-title":"J Neurosci Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(03)00174-5","article-title":"Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia.","volume":"343","author":"K Chu","year":"2003","journal-title":"Neurosci Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2004.04.038","article-title":"Human neural stem cells improve sensorimotor deficits in the rat brain with experimental focal ischemia.","volume":"1016","author":"K Chu","year":"2004","journal-title":"Brain Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.neures.2004.08.015","article-title":"Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem cells in rats with focal cerebral ischemia.","volume":"50","author":"K Chu","year":"2004","journal-title":"Neurosci Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1161\/01.STR.0000083698.20199.1F","article-title":"Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage.","volume":"34","author":"SW Jeong","year":"2003","journal-title":"Stroke"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"11839","DOI":"10.1073\/pnas.0404474101","article-title":"Transplanted human fetal neural stem cells survive, migrate and differentiate in ischemic rat cerebral cortex.","volume":"101","author":"S Kelly","year":"2004","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/3473","article-title":"Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes.","volume":"16","author":"JD Flax","year":"1998","journal-title":"Nature Biotech"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1440-1789.2004.00552.x","article-title":"Human neural stem cells genetically modified for brain repair in neurological disorders.","volume":"24","author":"SU Kim","year":"2004","journal-title":"Neuropathology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/00001756-200208070-00020","article-title":"Human neural stem cells: Electrophysiological properties of voltage gated ion channels.","volume":"13","author":"T Cho","year":"2002","journal-title":"Neuroreport"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jnr.10507","article-title":"Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.","volume":"72","author":"JK Ryu","year":"2003","journal-title":"J Neurosci Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1440-1789.2006.00688.x","article-title":"Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease.","volume":"26","author":"SU Kim","year":"2006","journal-title":"Neuropathology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbd.2004.01.016","article-title":"Proactive transplantation of human neural stem cells blocks neuronal cell death in rat model of Huntington disease.","volume":"16","author":"JK Ryu","year":"2004","journal-title":"Neurobiol Disease"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neures.2005.03.016","article-title":"Intravenous administration of human neural stem cells induces functional recovery in Huntington&apos;s disease rat model.","volume":"52","author":"ST Lee","year":"2005","journal-title":"Neurosci Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/jnr.10764","article-title":"Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in mucopolysacchridosis VII mouse.","volume":"74","author":"XL Meng","year":"2003","journal-title":"J Neurosci Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen.","volume":"246","author":"DW Leung","year":"1989","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"30336","DOI":"10.1074\/jbc.273.46.30336","article-title":"Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3\u2032-kinase\/Akt signal transduction pathway. Requirement for Flk-1\/KDR activation.","volume":"273","author":"HP Gerber","year":"1998","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00004647-199808000-00009","article-title":"Reduction of ischemic damage by application of vascular endothelial factor in rat brain after transient ischemia.","volume":"18","author":"T Hayashi","year":"1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain.","volume":"106","author":"ZG Zhang","year":"2000","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00701-002-1035-1","article-title":"Effects of intraventricular infusion of vascular endothelial growth factor on cerebral flow, edema and infarct volume.","volume":"145","author":"MR Harrigan","year":"2003","journal-title":"Acta Neurochir"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.","volume":"111","author":"Y Sun","year":"2003","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.jcbfm.9600109","article-title":"VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly.","volume":"25","author":"D Kaya","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(83)90522-X","article-title":"Culture of purified rat astrocytes in serum-free medium supplemented with mitogen.","volume":"274","author":"SU Kim","year":"1983","journal-title":"Brain Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jnr.490150303","article-title":"Neuroimmunology of gangliosides in human neurons and glial cells in culture.","volume":"15","author":"SU Kim","year":"1986","journal-title":"J Neurosci Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1161\/01.STR.27.12.2312","article-title":"Experimental intracerebral hemorrhage in rats. Magnetic resonance imaging and histopathological correlates.","volume":"27","author":"MR Del Bigio","year":"1996","journal-title":"Stroke"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0028-3908(00)00182-9","article-title":"An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats.","volume":"40","author":"K Puurunen","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref33","first-page":"482.497","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator.","volume":"231","author":"MJ West","year":"1991","journal-title":"Anat Rec"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref35","article-title":"The Rat Brain in Stereotaxic Coordinates.","author":"G Paxinos","year":"2003"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their recptors: a convergence point for many signalling pathways.","volume":"4","author":"MV Chao","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000138023.60272.9e","article-title":"Targets for vascular protection after acute ischemic stroke.","volume":"35","author":"SC Fagan","year":"2004","journal-title":"Stroke"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1602\/neurorx.1.1.26","article-title":"Hypoxic preconditioning protects against Ischemic brain injury.","volume":"1","author":"FR Sharp","year":"2004","journal-title":"NeuroRx"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1073\/pnas.97.18.10242","article-title":"Vascular endothelial growth factor: direct neuroprotective effect in vitro ischemia.","volume":"97","author":"KL Jin","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1096\/fj.00-0495fje","article-title":"Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.","volume":"15","author":"H Matsuzaki","year":"2001","journal-title":"FASEB J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/01.wcb.0000037988.07114.98","article-title":"Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism.","volume":"22","author":"B Svensson","year":"2002","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00005072-199906000-00010","article-title":"Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct.","volume":"58","author":"KH Plate","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/brain\/awh325","article-title":"VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena.","volume":"128","author":"Y Wang","year":"2005","journal-title":"Brain"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00005072-199906000-00006","article-title":"Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain.","volume":"58","author":"MA Proescholdt","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1050-1738(01)00149-9","article-title":"Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia.","volume":"12","author":"Z Zhang","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-1-4615-0123-7_14","article-title":"Vascular endothelial growth factor.","volume":"513","author":"HH Marti","year":"2002","journal-title":"Adv Exp Med Biol."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1097\/00001756-200110290-00046","article-title":"Focal cerebral ischemia causes two emporal waves of Akt activation.","volume":"12","author":"B Friguls","year":"2001","journal-title":"Neuroreport"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1038\/sj.onc.1207115","article-title":"PI3K\/AKT and apoptosis: Size matters.","volume":"22","author":"TF Franke","year":"2003","journal-title":"Oncogene"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrg1879","article-title":"The evolution of PI3-kinases as regulators of growth and metabolism.","volume":"7","author":"JA Engleman","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.expneurol.2004.01.022","article-title":"New roles for VEGF in nervous tissue-beyond blood vessels.","volume":"187","author":"JM Rosenstein","year":"2004","journal-title":"Exp Neurol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0000156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T16:18:53Z","timestamp":1556036333000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0000156"}},"subtitle":[],"editor":[{"given":"Maarten van","family":"lohuizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,1,17]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0000156","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,17]]}}}