{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:37:28Z","timestamp":1768279048498,"version":"3.49.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0000756","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T22:26:22Z","timestamp":1187735182000},"page":"e756","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":92,"title":["CSF Metabolic and Proteomic Profiles in Patients Prodromal for Psychosis"],"prefix":"10.1371","volume":"2","author":[{"given":"Jeffrey T.-J.","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Markus","family":"Leweke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsz M.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Koethe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kranaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph W.","family":"Gerth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Ruhrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Schultze-Lutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Klosterk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Bahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/schbul\/22.2.353","article-title":"The prodromal phase of first-episode psychosis: past and current conceptualizations.","volume":"22","author":"AR Yung","year":"1996","journal-title":"Schizophr Bull"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0920-9964(02)00167-6","article-title":"Psychosis prediction: 12-month follow up of a high-risk (\u201cprodromal\u201d) group.","volume":"60","author":"AR Yung","year":"2003","journal-title":"Schizophr Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archpsyc.62.9.975","article-title":"Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review.","volume":"62","author":"M Marshall","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/archpsyc.58.2.158","article-title":"Diagnosing schizophrenia in the initial prodromal phase.","volume":"58","author":"J Klosterkotter","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1055\/s-2003-45125","article-title":"Early detection and intervention in the initial prodromal phase of schizophrenia.","volume":"36","author":"S Ruhrmann","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1046\/j.1440-1614.2000.00798.x","article-title":"Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria.","volume":"34","author":"LJ Phillips","year":"2000","journal-title":"Aust N Z J Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1371\/journal.pmed.0030428","article-title":"Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis.","volume":"3","author":"JT Huang","year":"2006","journal-title":"PLoS Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pmed.0030327","article-title":"Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia.","volume":"3","author":"E Holmes","year":"2006","journal-title":"PLoS Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.biopsych.2005.09.005","article-title":"Generalized and specific neurocognitive deficits in prodromal schizophrenia.","volume":"59","author":"T Lencz","year":"2006","journal-title":"Biol Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1022034115078","article-title":"Symptom assessment in schizophrenic prodromal states.","volume":"70","author":"TJ Miller","year":"1999","journal-title":"Psychiatr Q"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0920-9964(03)00192-0","article-title":"Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features.","volume":"67","author":"AR Yung","year":"2004","journal-title":"Schizophr Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/oxfordjournals.schbul.a007041","article-title":"The assessment of \u201cprodromal schizophrenia\u201d: unresolved issues and future directions.","volume":"29","author":"T Lencz","year":"2003","journal-title":"Schizophr Bull"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/oxfordjournals.schbul.a007048","article-title":"A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus.","volume":"29","author":"LJ Seidman","year":"2003","journal-title":"Schizophr Bull"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2005.03168.x","article-title":"Monocarboxylate transporters in the central nervous system: distribution, regulation and function.","volume":"94","author":"K Pierre","year":"2005","journal-title":"J Neurochem"},{"key":"ref15","first-page":"E169","article-title":"Regional ketone body utilization by rat brain in starvation and diabetes.","volume":"250","author":"RA Hawkins","year":"1986","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(82)90257-4","article-title":"Lactate as energy source for brain in glucose-6-phosphatase deficient child.","volume":"1","author":"J Fernandes","year":"1982","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1023\/B:CEMN.0000023627.79947.22","article-title":"Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor.","volume":"24","author":"A Levi","year":"2004","journal-title":"Cell Mol Neurobiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/frne.2000.0199","article-title":"VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance.","volume":"21","author":"SR Salton","year":"2000","journal-title":"Front Neuroendocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0896-6273(00)80806-5","article-title":"Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.","volume":"23","author":"S Hahm","year":"1999","journal-title":"Neuron"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1677\/joe.0.1750061","article-title":"The evolutionary and integrative roles of transthyretin in thyroid hormone homeostasis.","volume":"175","author":"G Schreiber","year":"2002","journal-title":"J Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia.","volume":"13","author":"SR Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1212\/WNL.57.12.2310","article-title":"\u201cAtraumatic\u201d Sprotte needle reduces the incidence of post-lumbar puncture headaches.","volume":"57","author":"M Strupp","year":"2001","journal-title":"Neurology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1192\/bjp.185.4.291","article-title":"Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial.","volume":"185","author":"AP Morrison","year":"2004","journal-title":"Br J Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1176\/appi.ajp.159.5.863","article-title":"Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity.","volume":"159","author":"TJ Miller","year":"2002","journal-title":"Am J Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archpsyc.59.10.921","article-title":"Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms.","volume":"59","author":"PD McGorry","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1176\/ajp.2006.163.5.790","article-title":"Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.","volume":"163","author":"TH McGlashan","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref27","first-page":"S27","article-title":"The Schizophrenia Proneness Instrument (SPI-A) \u2013 a tool for the assessment of basic symptoms.","volume":"21","author":"F Schultze-Lutter","year":"2006","journal-title":"European Psychiatry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.schbul.a007040","article-title":"Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability.","volume":"29","author":"TJ Miller","year":"2003","journal-title":"Schizophr Bull"},{"key":"ref29","article-title":"Strukturiertes Klinisches Interview f\u00fcr DSM-IV.","author":"HU Wittchen","year":"1997"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0000756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T21:33:48Z","timestamp":1539984828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0000756"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Baune","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2007,8,22]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2007,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0000756","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,22]]}}}