{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:54:30Z","timestamp":1791204870920,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T00:00:00Z","timestamp":1188950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0000819","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T23:42:13Z","timestamp":1188949333000},"page":"e819","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":109,"title":["rs1004819 Is the Main Disease-Associated IL23R Variant in German Crohn's Disease Patients: Combined Analysis of IL23R, CARD15, and OCTN1\/2 Variants"],"prefix":"10.1371","volume":"2","author":[{"given":"J\u00fcrgen","family":"Glas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Seiderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wetzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga-Paula","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Schmechel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurian","family":"Tonenchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Grassl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dambacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pfennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Griga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg T.","family":"Epplen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Schiemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Folwaczny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"G\u00f6ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ochsenk\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"M\u00fcller-Myhsok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Folwaczny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mussack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease.","volume":"347","author":"DK Podolsky","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.","volume":"3","author":"RB Sartor","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.","volume":"411","author":"Y Ogura","year":"2001","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.","volume":"411","author":"JP Hugot","year":"2001","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/01.MIB.0000168372.94907.d2","article-title":"The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15\/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.","volume":"11","author":"S Brand","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1572-0241.2005.00361.x","article-title":"Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease phenotype.","volume":"101","author":"S Brand","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ibd.20008","article-title":"Macrophage migration inhibitory factor (MIF) -173G\/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.","volume":"13","author":"J Dambacher","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ng1339","article-title":"Functional variants of OCTN cation transporter genes are associated with Crohn disease.","volume":"36","author":"VD Peltekova","year":"2004","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00251-005-0073-2","article-title":"Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease.","volume":"58","author":"F Schnitzler","year":"2006","journal-title":"Immunogenetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1136\/gut.2005.066340","article-title":"Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.","volume":"54","author":"HP Torok","year":"2005","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.ibd.0000225346.23765.6b","article-title":"Role of the NFKB1 -94ins\/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15\/NOD2, IKBL, and IL-1RN genes.","volume":"12","author":"J Glas","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.","volume":"314","author":"RH Duerr","year":"2006","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1053\/j.gastro.2007.02.051","article-title":"IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease.","volume":"132","author":"M Tremelling","year":"2007","journal-title":"Gastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ibd.20126","article-title":"IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.","volume":"13","author":"MC Dubinsky","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1136\/gut.2007.122069","article-title":"IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland.","volume":"56","author":"JE Van Limbergen","year":"2007","journal-title":"Gut"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.","volume":"24","author":"M Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"ref17","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.","author":"L Zhou","year":"2007","journal-title":"Nat Immunol Jun 20; [Epub ahead of print]"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","article-title":"IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.","volume":"448","author":"T Korn","year":"2007","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.","volume":"448","author":"R Nurieva","year":"2007","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nm0107-26","article-title":"IL-23: a master regulator in Crohn disease.","volume":"13","author":"MF Neurath","year":"2007","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.","volume":"116","author":"D Yen","year":"2006","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.4049\/jimmunol.177.5.2760","article-title":"Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.","volume":"177","author":"C Becker","year":"2006","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20061099","article-title":"Interleukin-23 drives innate and T cell-mediated intestinal inflammation.","volume":"203","author":"S Hue","year":"2006","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature04808","article-title":"IL-23 promotes tumour incidence and growth.","volume":"442","author":"JL Langowski","year":"2006","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s00262-006-0171-5","article-title":"Immune enhancement and anti-tumour activity of IL-23.","volume":"55","author":"JS Hao","year":"2006","journal-title":"Cancer Immunol Immunother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4049\/jimmunol.178.4.2589","article-title":"IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis.","volume":"178","author":"P Thakker","year":"2007","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.4049\/jimmunol.176.12.7768","article-title":"IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.","volume":"176","author":"A Vaknin-Dembinsky","year":"2006","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1053\/j.gastro.2007.03.104","article-title":"Monoclonal anti-interleukin-23 reverses active colitis in a T cell-mediated model in mice.","volume":"132","author":"CO Elson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.MIB.0000194183.92671.b6","article-title":"Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody.","volume":"12","author":"IJ Fuss","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1172\/JCI200317464","article-title":"Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells.","volume":"112","author":"C Becker","year":"2003","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1126\/science.1102901","article-title":"CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.","volume":"307","author":"JH Niess","year":"2005","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.molimm.2006.09.001","article-title":"TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells.","volume":"44","author":"Z Waibler","year":"2007","journal-title":"Mol Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1172\/JCI30150","article-title":"Dependence of intestinal granuloma formation on unique myeloid DC-like cells.","volume":"117","author":"A Mizoguchi","year":"2007","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.1136668","article-title":"Genetics. Delivering new disease genes.","volume":"314","author":"LR Cardon","year":"2006","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(00)05063-7","article-title":"Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.","volume":"357","author":"J Hampe","year":"2001","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1053\/j.gastro.2005.09.025","article-title":"The contribution of OCTN1\/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.","volume":"129","author":"CL Noble","year":"2005","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1080\/00365520600703900","article-title":"Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.","volume":"41","author":"J Seiderer","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/01.mib.0000235836.32176.5e","article-title":"Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study.","volume":"12","author":"J Seiderer","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","article-title":"Classification of inflammatory bowel disease.","volume":"170","author":"JE Lennard-Jones","year":"1989","journal-title":"Scand J Gastroenterol Suppl"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.","author":"MS Silverberg","year":"2005","journal-title":"Can J Gastroenterol 19 Suppl A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ng2032","article-title":"Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.","volume":"39","author":"JD Rioux","year":"2007","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1371\/journal.pgen.0030058","article-title":"Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4.","volume":"3","author":"C Libioulle","year":"2007","journal-title":"PLoS Genetics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/511051","article-title":"A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.","volume":"80","author":"M Cargill","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1056\/NEJMoa033402","article-title":"Anti-interleukin-12 antibody for active Crohn's disease.","volume":"351","author":"PJ Mannon","year":"2004","journal-title":"N Engl J Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa062382","article-title":"A human interleukin-12\/23 monoclonal antibody for the treatment of psoriasis.","volume":"356","author":"GG Krueger","year":"2007","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.intimp.2006.09.024","article-title":"After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?","volume":"7","author":"Z Zhang","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","article-title":"Antibodies to interleukin 12 abrogate established experimental colitis in mice.","volume":"182","author":"MF Neurath","year":"1995","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1084\/jem.187.8.1225","article-title":"T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12\/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells.","volume":"187","author":"SJ Simpson","year":"1998","journal-title":"J Exp Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.161.12.6480","article-title":"IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.","volume":"161","author":"EB Samoilova","year":"1998","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"G827","DOI":"10.1152\/ajpgi.00513.2005","article-title":"IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration.","volume":"290","author":"S Brand","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"G1019","DOI":"10.1152\/ajpgi.00239.2006","article-title":"IL-22-mediated liver cell regeneration is abrogated by SOCS-1\/3 overexpression in vitro.","volume":"292","author":"S Brand","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.","volume":"445","author":"Y Zheng","year":"2007","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","article-title":"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.","volume":"39","author":"J Hampe","year":"2007","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0000819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T01:16:08Z","timestamp":1684026968000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0000819"}},"subtitle":[],"editor":[{"given":"Florian","family":"Kronenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,9,5]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2007,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0000819","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,5]]}}}