{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:10:45Z","timestamp":1792116645763,"version":"4.4.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0000947","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T16:08:10Z","timestamp":1193242090000},"page":"e947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Complete Genomic Characterization of a Pathogenic A.II Strain of Francisella tularensis Subspecies tularensis"],"prefix":"10.1371","volume":"2","author":[{"given":"Stephen M.","family":"Beckstrom-Sternberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K.","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhada","family":"Godbole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Beckstrom-Sternberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Munk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Brettin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gilna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Keim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1749-6632.1992.tb38021.x","article-title":"Japanese biological warfare research on humans: a case study of microbiology and ethics.","volume":"666","author":"S Harris","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00196721","article-title":"Japanese biological warfare experiments and other atrocities in Manchuria, 1932\u20131945, and the subsequent United States cover up: a preliminary assessment.","volume":"15","author":"S Harris","year":"1991","journal-title":"Crime, Law and Social Change"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1001\/jama.285.21.2763","article-title":"Tularemia as a biological weapon: medical and public health management.","volume":"285","author":"DT Dennis","year":"2001","journal-title":"Jama"},{"key":"ref4","article-title":"Key Facts About Tularemia.","year":"2003"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3201\/eid1207.051504","article-title":"Epidemiologic and molecular analysis of human tularemia, United States, 1964\u20132004.","volume":"12","author":"JE Staples","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref6","article-title":"Molecular Epidemiology, Evolution, and Ecology of Francisella.","author":"PS Keim","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.1128\/AEM.71.9.5494-5500.2005","article-title":"Detection of diverse new Francisella-like bacteria in environmental samples.","volume":"71","author":"SM Barns","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3201\/eid1112.050728","article-title":"Francisella tularensis in the United States.","volume":"11","author":"J Farlow","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1128\/JB.186.17.5808-5818.2004","article-title":"Worldwide genetic relationships among Francisella tularensis isolates determined by multiple-locus variable-number tandem repeat analysis.","volume":"186","author":"A Johansson","year":"2004","journal-title":"J Bacteriol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1099\/00207713-33-4-872","article-title":"Subspecific taxonomy of Francisella tularensis McCoy and Chapin 1912.","volume":"33","author":"NG Lsufjev","year":"1983","journal-title":"International Journal of Systematic Bacteriology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ng1499","article-title":"The complete genome sequence of Francisella tularensis, the causative agent of tularemia.","volume":"37","author":"P Larsson","year":"2005","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1128\/MMBR.62.3.725-774.1998","article-title":"Insertion sequences.","volume":"62","author":"J Mahillon","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0022-2836(91)90490-W","article-title":"Programmed translational frameshifting and initiation at an AUU codon in gene expression of bacterial insertion sequence IS911.","volume":"222","author":"P Polard","year":"1991","journal-title":"J Mol Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1128\/JB.00506-06","article-title":"Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence.","volume":"188","author":"JF Petrosino","year":"2006","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1101\/gr.2289704","article-title":"Mauve: multiple alignment of conserved genomic sequence with rearrangements.","volume":"14","author":"AC Darling","year":"2004","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/IAI.01250-06","article-title":"Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis.","volume":"74","author":"A Brotcke","year":"2006","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1101\/gr.87702. Article published online before print in May 2002","article-title":"Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.","volume":"12","author":"IK Jordan","year":"2002","journal-title":"Genome Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/j.1365-2958.2006.05061.x","article-title":"Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis.","volume":"59","author":"AL Forslund","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1128\/IAI.01006-06","article-title":"Potential source of Francisella tularensis live vaccine strain attenuation determined by genome comparison.","volume":"74","author":"L Rohmer","year":"2006","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.1128\/IAI.73.12.8345-8352.2005","article-title":"A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.","volume":"73","author":"S Twine","year":"2005","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.micpath.2005.12.004","article-title":"Virulence comparison in mice of distinct isolates of type A Francisella tularensis.","volume":"40","author":"SM Twine","year":"2006","journal-title":"Microb Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gr.8.3.186","article-title":"Base-calling of automated sequencer traces using phred. II. Error probabilities.","volume":"8","author":"B Ewing","year":"1998","journal-title":"Genome Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using phred. I. Accuracy assessment.","volume":"8","author":"B Ewing","year":"1998","journal-title":"Genome Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/gr.8.3.195","article-title":"Consed: a graphical tool for sequence finishing.","volume":"8","author":"D Gordon","year":"1998","journal-title":"Genome Res"},{"key":"ref25","first-page":"142","article-title":"Finishing Repetitive Regions Automatically with Dupfinisher.","author":"C Han","year":"2006"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/nar\/27.11.2369","article-title":"Alignment of whole genomes.","volume":"27","author":"AL Delcher","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref27","article-title":"Manatee Home Page.","year":"2006"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.0955","article-title":"tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.","volume":"25","author":"TM Lowe","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2105-6-31","article-title":"Automated generation of heuristics for biological sequence comparison.","volume":"6","author":"GS Slater","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"D121","DOI":"10.1093\/nar\/gki081","article-title":"Rfam: annotating non-coding RNAs in complete genomes.","volume":"33","author":"S Griffiths-Jones","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref31","article-title":"Gene Finding\/Annotation.","year":"2007"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool.","volume":"215","author":"SF Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-2836(81)90087-5","article-title":"Identification of common molecular subsequences.","volume":"147","author":"TF Smith","year":"1981","journal-title":"J Mol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/28.1.263","article-title":"The Pfam protein families database.","volume":"28","author":"A Bateman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/nar\/29.1.41","article-title":"TIGRFAMs: a protein family resource for the functional identification of proteins.","volume":"29","author":"DH Haft","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.","volume":"305","author":"A Krogh","year":"2001","journal-title":"J Mol Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","author":"JD Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2105-4-41","article-title":"The COG database: an updated version includes eukaryotes.","volume":"4","author":"RL Tatusov","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"ref39","first-page":"72","article-title":"sDACS: A Novel In Silico SNP Discovery and Classification Method for Bacterial Pathogens [Master&apos;s Thesis]","author":"RK Auerbach","year":"2006"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/gb-2004-5-2-r12","article-title":"Versatile and open software for comparing large genomes.","volume":"5","author":"S Kurtz","year":"2004","journal-title":"Genome Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1093\/bioinformatics\/btg359","article-title":"DnaSP, DNA polymorphism analyses by the coalescent and other methods.","volume":"19","author":"J Rozas","year":"2003","journal-title":"Bioinformatics"},{"key":"ref42","article-title":"Age, Descent, and Genetic Diversity Within Yersinia pestis.","author":"M Achtman","year":"2004"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/bioinformatics\/bti054","article-title":"Circular genome visualization and exploration using CGView.","volume":"21","author":"P Stothard","year":"2005","journal-title":"Bioinformatics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0000947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:24:31Z","timestamp":1588965871000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0000947"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Petrosino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,9,26]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2007,9,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0000947","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,26]]}}}