{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:08:35Z","timestamp":1791328115200,"version":"4.3.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0001535","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T22:54:26Z","timestamp":1202252066000},"page":"e1535","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2"],"prefix":"10.1371","volume":"3","author":[{"given":"Say","family":"Viengchareun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Servel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freemark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lomb\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Binart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.physiol.64.081501.131049","article-title":"Prolactin: the new biology of an old hormone.","volume":"64","author":"V Goffin","year":"2002","journal-title":"Annu Rev Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1210\/edrv.19.3.0334","article-title":"Prolactin and its receptor: actions, signal transduction pathways and phenotypes observed in prolactin receptor knockout mice.","volume":"19","author":"C Bole-Feysot","year":"1998","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1210\/en.2006-1219","article-title":"In vivo response-based identification of direct hormone target cell populations using high-density tissue arrays.","volume":"148","author":"MJ LeBaron","year":"2007","journal-title":"Endocrinology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1210\/endo.133.4.8404626","article-title":"Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger RNA.","volume":"133","author":"M Freemark","year":"1993","journal-title":"Endocrinology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1210\/endo.136.9.7649097","article-title":"The prolactin receptor in the fetal rat: cellular localization of messenger RNA, immunoreactive protein, and ligand binding activity and induction of expression in late gestation.","volume":"136","author":"M Royster","year":"1995","journal-title":"Endocrinology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1172\/JCI119239","article-title":"Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.","volume":"99","author":"M Freemark","year":"1997","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance.","volume":"84","author":"B Cannon","year":"2004","journal-title":"Physiol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.2000.00003.x","article-title":"Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance.","volume":"529 Pt 1","author":"D Ricquier","year":"2000","journal-title":"J Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/er.2006-0037","article-title":"Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.","volume":"27","author":"C Handschin","year":"2006","journal-title":"Endocr Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.cellbio.16.1.145","article-title":"Molecular regulation of adipogenesis.","volume":"16","author":"ED Rosen","year":"2000","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.","volume":"16","author":"ED Rosen","year":"2002","journal-title":"Genes Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1210\/me.2003-0267","article-title":"Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.","volume":"18","author":"V Golozoubova","year":"2004","journal-title":"Mol Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-5793(02)03387-2","article-title":"Beta(1)\/beta(2)\/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.","volume":"530","author":"M Jimenez","year":"2002","journal-title":"FEBS Lett"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1016\/j.febslet.2006.07.037","article-title":"The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture.","volume":"580","author":"L Lehr","year":"2006","journal-title":"FEBS Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1172\/JCI13103","article-title":"Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.","volume":"108","author":"C Guerra","year":"2001","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1128\/MCB.21.7.2521-2532.2001","article-title":"Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.","volume":"21","author":"H Miki","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1101\/gad.1034802","article-title":"Lipoatrophic diabetes in Irs1(-\/-)\/Irs3(-\/-) double knockout mice.","volume":"16","author":"PG Laustsen","year":"2002","journal-title":"Genes Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1677\/jme.1.01563","article-title":"Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes.","volume":"33","author":"S Viengchareun","year":"2004","journal-title":"J Mol Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1101\/gad.11.2.167","article-title":"Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.","volume":"11","author":"CJ Ormandy","year":"1997","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1172\/JCI1915","article-title":"Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action.","volume":"101","author":"MC Zennaro","year":"1998","journal-title":"J Clin Invest"},{"key":"ref21","first-page":"955","article-title":"Genetics of mouse growth.","volume":"42","author":"A Efstratiadis","year":"1998","journal-title":"Int J Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2005.104141","article-title":"Programming placental nutrient transport capacity.","volume":"572","author":"AL Fowden","year":"2006","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1210\/me.2004-0193","article-title":"Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.","volume":"18","author":"S Collins","year":"2004","journal-title":"Mol Endocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(02)00365-9","article-title":"IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.","volume":"3","author":"C Brisken","year":"2002","journal-title":"Dev Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1128\/MCB.19.5.3278","article-title":"Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.","volume":"19","author":"F Frasca","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"42178","DOI":"10.1074\/jbc.M304980200","article-title":"Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A.","volume":"278","author":"G Pandini","year":"2003","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"15399","DOI":"10.1074\/jbc.275.20.15399","article-title":"Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.","volume":"275","author":"RC Vasavada","year":"2000","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/endo.143.4.8722","article-title":"Targeted deletion of the prolactin receptor: effects on islet development, insulin production, and glucose tolerance.","volume":"143","author":"M Freemark","year":"2002","journal-title":"Endocrinology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tem.2006.02.005","article-title":"Focus on prolactin as a metabolic hormone.","volume":"17","author":"N Ben Jonathan","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1210\/endo.141.10.7691","article-title":"Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice.","volume":"141","author":"C Ling","year":"2000","journal-title":"Endocrinology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1073\/pnas.0400356101","article-title":"Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.","volume":"101","author":"T Imai","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","article-title":"Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.","volume":"119","author":"J Lin","year":"2004","journal-title":"Cell"},{"key":"ref33","article-title":"Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired PPAR{gamma} (P465L PPAR{gamma}) function.","author":"SL Gray","year":"2006","journal-title":"Endocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1677\/joe.1.05732","article-title":"Prolactin, the prolactin receptor and uncoupling protein abundance and function in adipose tissue during development in young sheep.","volume":"184","author":"S Pearce","year":"2005","journal-title":"J Endocrinol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"8497","DOI":"10.1158\/0008-5472.CAN-04-3937","article-title":"Medullary thyroid carcinoma arises in the absence of prolactin signaling.","volume":"65","author":"C Kedzia","year":"2005","journal-title":"Cancer Res"},{"key":"ref36","first-page":"307","article-title":"Prolactin enhances CCAAT enhancer-binding protein-beta (C\/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells.","volume":"14","author":"R Nanbu-Wakao","year":"2000","journal-title":"Mol Endocrinol"},{"key":"ref37","first-page":"532","article-title":"Body weight and fat deposition in prolactin receptor-deficient mice.","volume":"142","author":"M Freemark","year":"2001","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/B:PITU.0000004800.57449.67","article-title":"Effects of growth hormone and prolactin on adipose tissue development and function.","volume":"6","author":"DJ Flint","year":"2003","journal-title":"Pituitary"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1677\/joe.1.06939","article-title":"Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity.","volume":"191","author":"DJ Flint","year":"2006","journal-title":"J Endocrinol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1210\/jc.2005-0721","article-title":"Inaccuracy of insulin-like growth factor (IGF) binding protein (IGFBP)-3 assessment in the diagnosis of growth hormone (GH) deficiency from childhood to young adulthood: association to low GH dependency of IGF-II and presence of circulating IGFBP-3 18-kilodalton fragment.","volume":"90","author":"S Cianfarani","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ncb1259","article-title":"Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.","volume":"7","author":"YH Tseng","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cmet.2005.08.006","article-title":"Changes in integrin expression during adipocyte differentiation.","volume":"2","author":"J Liu","year":"2005","journal-title":"Cell Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1128\/MCB.25.4.1272-1282.2005","article-title":"Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha.","volume":"25","author":"S Kang","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1210\/endo.141.7.7568","article-title":"Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration.","volume":"141","author":"N Binart","year":"2000","journal-title":"Endocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10496","DOI":"10.1074\/jbc.M512254200","article-title":"Functional IsK\/KvLQT1 potassium channel in a new corticosteroid-sensitive cell line derived from the inner ear.","volume":"281","author":"M Teixeira","year":"2006","journal-title":"J Biol Chem"},{"key":"ref46","first-page":"637","article-title":"Development of a simple valid method for the complete removal of insulin-like growth factor (IGF)-binding proteins from IGFs in human serum and other biological fluids: comparison with acid-ethanol treatment and C18 Sep-Pak separation.","volume":"80","author":"S Mohan","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"34795","DOI":"10.1074\/jbc.274.49.34795","article-title":"beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.","volume":"274","author":"J Klein","year":"1999","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"16573","DOI":"10.1074\/jbc.271.28.16573","article-title":"Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay.","volume":"271","author":"V Goffin","year":"1996","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/bj2920577","article-title":"Characterization of the interaction of the human mineralocorticosteroid receptor with hormone response elements.","volume":"2092","author":"M Lombes","year":"1993","journal-title":"Biochem J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0001535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T18:07:47Z","timestamp":1557252467000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0001535"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Callaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,2,6]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0001535","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,6]]}}}