{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:51:09Z","timestamp":1793055069932,"version":"4.5.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T00:00:00Z","timestamp":1204675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0001709","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T22:53:38Z","timestamp":1204671218000},"page":"e1709","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":274,"title":["SnoRNA Snord116 (Pwcr1\/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice"],"prefix":"10.1371","volume":"3","author":[{"given":"Feng","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Camper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinchas","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Francke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.91.2.398","article-title":"Prader-Willi syndrome: consensus diagnostic criteria.","volume":"91","author":"VA Holm","year":"1993","journal-title":"Pediatrics"},{"key":"ref2","first-page":"429","article-title":"Prader-Willi Syndrome.","author":"SB Cassidy","year":"2005"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.genom.2.1.153","article-title":"Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes.","volume":"2","author":"RD Nicholls","year":"2001","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1086\/342408","article-title":"Evidence for the role of PWCR1\/HBII-85 C\/D box small nucleolar RNAs in Prader-Willi syndrome.","volume":"71","author":"RC Gallagher","year":"2002","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2350-6-18","article-title":"Molecular breakpoint cloning and gene expression studies of a novel translocation t(4;15)(q27;q11.2) associated with Prader-Willi syndrome.","volume":"6","author":"B Sch\u00fcle","year":"2005","journal-title":"BMC Med Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1086\/303106","article-title":"Small evolutionarily conserved RNA, resembling C\/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which is highly expressed in brain.","volume":"67","author":"T de Los Santos","year":"2000","journal-title":"Am J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"14311","DOI":"10.1073\/pnas.250426397","article-title":"Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization.","volume":"97","author":"J Cavaille","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/hmg\/10.4.383","article-title":"Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes.","volume":"10","author":"M Meguro","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1093\/hmg\/10.23.2687","article-title":"The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A.","volume":"10","author":"M Runte","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0092-8674(02)00718-3","article-title":"Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions.","volume":"109","author":"T Kiss","year":"2002","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.1118265","article-title":"The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C.","volume":"311","author":"S Kishore","year":"2006","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00335-005-2460-2","article-title":"Lack of Pwcr1\/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models.","volume":"16","author":"F Ding","year":"2005","journal-title":"Mamm Genome"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00439-004-1219-2","article-title":"Exclusion of the C\/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome.","volume":"116","author":"M Runte","year":"2005","journal-title":"Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0598-25","article-title":"A mouse model for Prader-Willi syndrome imprinting-centre mutations.","volume":"19","author":"T Yang","year":"1998","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1471-2164-6-157","article-title":"Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.","volume":"6","author":"M Stefan","year":"2005","journal-title":"BMC Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1073\/pnas.96.16.9258","article-title":"A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes.","volume":"96","author":"JM Gabriel","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1093\/hmg\/ddh314","article-title":"Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice.","volume":"13","author":"SJ Chamberlain","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/hmg\/8.8.1357","article-title":"Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome.","volume":"8","author":"TF Tsai","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tem.2003.11.003","article-title":"Prader-Willi syndrome: advances in genetics, pathophysiology and treatment.","volume":"15","author":"AP Goldstone","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(03)14370-X","article-title":"The paradox of Prader-Willi syndrome: a genetic model of starvation.","volume":"362","author":"A Holland","year":"2003","journal-title":"Lancet"},{"key":"ref21","first-page":"62","article-title":"Mouse Genetics.","author":"LM Silver","year":"1995"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1371\/journal.pbio.0030415","article-title":"Effects of hypothalamic neurodegeneration on energy balance.","volume":"3","author":"AW Xu","year":"2005","journal-title":"PLoS Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1371\/journal.pgen.0020081","article-title":"Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.","volume":"2","author":"RA Koza","year":"2006","journal-title":"PLoS Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0300-9629(74)90128-5","article-title":"The response of \u201cobese\u201d (ob-ob) and \u201cdiabetic\u201d (db-db) mice to treatments that influence body temperature.","volume":"49","author":"TT Yen","year":"1974","journal-title":"Comp Biochem Physiol A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/266060a0","article-title":"Thermogenic defect in pre-obese ob\/ob mice.","volume":"266","author":"P Trayhurn","year":"1977","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10803-004-5295-x","article-title":"Do known mutations in neuroligin genes (NLGN3 and NLGN4) cause autism?","volume":"34","author":"Z Talebizadeh","year":"2004","journal-title":"J Autism Dev Disord"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ydbio.2005.07.030","article-title":"Dynamic developmental regulation of the large non-coding RNA associated with the mouse 7C imprinted chromosomal region.","volume":"286","author":"E Le Meur","year":"2005","journal-title":"Dev Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1128\/MCB.14.9.5766","article-title":"U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals.","volume":"14","author":"M Nicoloso","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/edrv.22.6.0447","article-title":"Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH.","volume":"22","author":"P Burman","year":"2001","journal-title":"Endocr Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1515\/JPEM.2004.17.4.591","article-title":"Growth hormone improves body composition and motor development in infants with Prader-Willi syndrome after six months.","volume":"17","author":"B Whitman","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/ajmg.a.31824","article-title":"Final adult height in children with Prader-Willi syndrome with and without human growth hormone treatment.","volume":"143","author":"MA Angulo","year":"2007","journal-title":"Am J Med Genet A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"13215","DOI":"10.1073\/pnas.94.24.13215","article-title":"A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor\/binding protein gene (the Laron mouse).","volume":"94","author":"Y Zhou","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oxfordjournals.jhered.a108682","article-title":"Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6.","volume":"67","author":"EM Eicher","year":"1976","journal-title":"J Hered"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1651-2227.1990.tb11677.x","article-title":"Growth hormone binding proteins and various forms of growth hormone: implications for measurements.","volume":"370","author":"G Baumann","year":"1990","journal-title":"Acta Paediatr Scand Suppl"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1210\/endo.141.7.7586","article-title":"Assessment of growth parameters and life span of GHR\/BP gene-disrupted mice.","volume":"141","author":"KT Coschigano","year":"2000","journal-title":"Endocrinology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1651-2227.1997.tb18369.x","article-title":"Prader-Willi syndrome and the hypothalamus.","volume":"423","author":"DF Swaab","year":"1997","journal-title":"Acta Paediatr Suppl"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-2265.2003.01788.x","article-title":"Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity.","volume":"58","author":"AP Goldstone","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/364208a0","article-title":"Molecular basis of the little mouse phenotype and implications for cell type-specific growth.","volume":"364","author":"SC Lin","year":"1993","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/oby.2006.118","article-title":"Neural mechanisms underlying hyperphagia in Prader-Willi syndrome.","volume":"14","author":"LM Holsen","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/jnnp.2006.099044","article-title":"Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome.","volume":"78","author":"JL Miller","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/ajcn\/46.2.277","article-title":"Characteristics of abnormal food-intake patterns in children with Prader-Willi syndrome and study of effects of naloxone.","volume":"46","author":"WB Zipf","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"ref42","first-page":"527","article-title":"Measurement of excessive appetite and metabolic changes in Prader-Willi syndrome.","volume":"17","author":"AJ Holland","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1067\/mpd.2000.106563","article-title":"Eating behavior in Prader-Willi syndrome, normal weight, and obese control groups.","volume":"137","author":"AC Lindgren","year":"2000","journal-title":"J Pediatr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.ijo.0803128","article-title":"Neural representations of hunger and satiety in Prader-Willi syndrome.","volume":"30","author":"EC Hinton","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1073\/pnas.0303992101","article-title":"Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.","volume":"101","author":"Q Gao","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2006.07.004","article-title":"From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants.","volume":"79","author":"N Pecoraro","year":"2006","journal-title":"Prog Neurobiol"},{"key":"ref47","first-page":"215","article-title":"Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity.","volume":"58","author":"D L'Allemand","year":"2002","journal-title":"Horm Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/j.1550-8528.1998.tb00311.x","article-title":"Food intake in Prader-Willi syndrome and controls with obesity after administration of a benzodiazepine receptor agonist.","volume":"6","author":"A Fieldstone","year":"1998","journal-title":"Obes Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1096-8628(19980106)75:1<7::AID-AJMG3>3.0.CO;2-T","article-title":"Comparison of leptin protein levels in Prader-Willi syndrome and control individuals.","volume":"75","author":"MG Butler","year":"1998","journal-title":"Am J Med Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1210\/jc.2002-020871","article-title":"High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.","volume":"87","author":"A DelParigi","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nm0702-643","article-title":"Elevated plasma ghrelin levels in Prader Willi syndrome.","volume":"8","author":"DE Cummings","year":"2002","journal-title":"Nat Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1210\/jc.2002-021052","article-title":"Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.","volume":"88","author":"AM Haqq","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1210\/jc.2004-1935","article-title":"Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome.","volume":"90","author":"YH Choe","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents.","volume":"407","author":"M Tschop","year":"2000","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1124\/jpet.102.034827","article-title":"Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure.","volume":"302","author":"WA Banks","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1210\/jc.2004-0835","article-title":"Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome.","volume":"89","author":"TM Tan","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome.","volume":"2","author":"W Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1113\/jphysiol.2002.033274","article-title":"Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.","volume":"547","author":"W Reik","year":"2003","journal-title":"J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcp.10129","article-title":"Physiological functions of imprinted genes.","volume":"192","author":"B Tycko","year":"2002","journal-title":"J Cell Physiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/520063","article-title":"DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency.","volume":"81","author":"B Sch\u00fcle","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1210\/me.2005-0483","article-title":"Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.","volume":"20","author":"BM Kublaoui","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice.","volume":"88","author":"D Huszar","year":"1997","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight.","volume":"443","author":"GJ Morton","year":"2006","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1021\/bi962443e","article-title":"Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay.","volume":"36","author":"J Seibler","year":"1997","journal-title":"Biochemistry"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1021\/bi00209a003","article-title":"Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci.","volume":"33","author":"T Schlake","year":"1994","journal-title":"Biochemistry"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tig.2003.12.006","article-title":"To knockout in 129 or in C57BL\/6: that is the question.","volume":"20","author":"E Seong","year":"2004","journal-title":"Trends Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/gene.1076","article-title":"Efficient FLP recombination in mouse ES cells and oocytes.","volume":"31","author":"J Schaft","year":"2001","journal-title":"Genesis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/hmg\/ddl146","article-title":"Ube3a expression is not altered in Mecp2 mutant mice.","volume":"15","author":"C Jordan","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1210\/en.2005-0371","article-title":"Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive.","volume":"146","author":"M Stefan","year":"2005","journal-title":"Endocrinology"},{"key":"ref70","article-title":"Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit.","author":"DL Hwang","year":"2007","journal-title":"Growth Horm IGF Res. (doi:10.1016\/j.ghir.2007.07.007)."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0001709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T20:47:01Z","timestamp":1684270021000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0001709"}},"subtitle":[],"editor":[{"given":"Schahram","family":"Akbarian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,3,5]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0001709","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,5]]}}}