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Adams","year":"2001","journal-title":"Proteomics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1128\/IAI.67.8.4099-4105.1999","article-title":"Differential regulation of <italic>Salmonella typhimurium<\/italic> type III secreted proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional activators InvF and hilA.","volume":"67","author":"K Eichelberg","year":"1999","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2958.2003.03583.x","article-title":"The <italic>Erwinia chrysanthemi<\/italic> phoP-phoQ operon plays an important role in growth at low pH, virulence and bacterial survival in plant tissue.","volume":"49","author":"A Llama-Palacios","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1128\/IAI.68.6.3419-3425.2000","article-title":"The response regulator PhoP is important for survival under conditions of 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