{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:46:09Z","timestamp":1791351969083,"version":"4.3.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0001888","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T19:38:43Z","timestamp":1206473923000},"page":"e1888","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":105,"title":["The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection"],"prefix":"10.1371","volume":"3","author":[{"given":"Ada","family":"De Luigi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Diomede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Capobianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Mangieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Miccolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Limido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJM200105173442006","article-title":"Shattuck lecture\u2013neurodegenerative diseases and prions.","volume":"344","author":"SB Prusiner","year":"2001","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions.","volume":"95","author":"SB Prusiner","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/bmb\/66.1.21","article-title":"Biochemistry and structure of PrP(C) and PrP(Sc).","volume":"66","author":"D Riesner","year":"2003","journal-title":"Br Med Bull"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archneur.63.4.497","article-title":"Emerging pharmacotherapies for Creutzfeldt-Jakob disease.","volume":"63","author":"C Korth","year":"2006","journal-title":"Arch Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00023210-200620010-00002","article-title":"Prion diseases: current understanding of epidemiology and pathogenesis, and therapeutic advances.","volume":"20","author":"M Caramelli","year":"2006","journal-title":"CNS Drugs"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.56.062404.172936","article-title":"Approaches to therapy of prion diseases.","volume":"56","author":"C Weissmann","year":"2005","journal-title":"Annu Rev Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1568013033483456","article-title":"Prion disease: time for a therapy ?","volume":"3","author":"G Forloni","year":"2003","journal-title":"Curr Med Chem-Immun, Endoc & Metab Agents"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jinf.2004.07.015","article-title":"Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.","volume":"50","author":"NV Todd","year":"2005","journal-title":"J Infect"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1517\/14712598.7.5.713","article-title":"Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?","volume":"7","author":"NG Rainov","year":"2007","journal-title":"Expert Opin Biol Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000076350","article-title":"Results of quinacrine administration to patients with Creutzfeldt-Jakob disease.","volume":"17","author":"M Nakajima","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.wnf.0000134853.36429.0e","article-title":"Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.","volume":"27","author":"J Benito-Leon","year":"2004","journal-title":"Clin Neuropharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1212\/01.WNL.0000113764.35026.EF","article-title":"Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.","volume":"62","author":"M Otto","year":"2004","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1006\/jmbi.2000.3840","article-title":"Tetracycline affects abnormal properties of synthetic PrP peptides and PrP (Sc) in vitro.","volume":"300","author":"F Tagliavini","year":"2000","journal-title":"J Mol Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2004.10.001","article-title":"Neuroprotection by tetracyclines.","volume":"25","author":"M Domercq","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00894-004-0213-x","article-title":"Tetracycline and its analogues as inhibitors of amyloid fibrils: searching for a geometrical pharmacophore by theoretical investigation of their conformational behavior in aqueous solution.","volume":"11","author":"U Cosentino","year":"2005","journal-title":"J Mol Model"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1073\/pnas.162195499","article-title":"Tetracyclines affect prion infectivity.","volume":"99","author":"G Forloni","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.276.5315.1119","article-title":"Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.","volume":"276","author":"F Tagliavini","year":"1997","journal-title":"Science"},{"key":"ref18","first-page":"139","article-title":"Lipid peroxidation in liposome. In: Gregoriadis G, ed. Liposome technology.","author":"AWT Konings","year":"1984"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1570-0232(03)00247-2","article-title":"Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat.","volume":"791","author":"M Colovic","year":"2003","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1750-3639.2000.tb00240.x","article-title":"Creutzfeldt-Jakob disease: Carnoy&apos;s fixative improves the immunohistochemistry of the proteinase K-resistant prion protein.","volume":"10","author":"G Giaccone","year":"2000","journal-title":"Brain Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1046\/j.1432-1327.1999.00985.x","article-title":"Determination of solution conformations of PrP106-126, a neurotoxic fragment of prion protein, by 1H NMR and restrained molecular dynamics.","volume":"266","author":"E Ragg","year":"1999","journal-title":"Eur J Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1096\/fj.05-4652fje","article-title":"Tetracycline inhibits W7FW14F apomyoglobin fibril extension and keeps the amyloid protein in a pre-fibrillar, highly cytotoxic state.","volume":"20","author":"C Malmo","year":"2006","journal-title":"FASEB J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1471-4159.2006.03707.x","article-title":"Antioxidant compounds have potent anti-fibrillogenic and fibril- destabilizing effects for alpha-synuclein fibrils in vitro.","volume":"97","author":"K Ono","year":"2006","journal-title":"J Neurochem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj20030422","article-title":"Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.","volume":"374","author":"JF Aitken","year":"2003","journal-title":"Biochem J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1096\/fj.02-0764com","article-title":"4\u2032-iodo-4\u2032-deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters.","volume":"17","author":"I Cardoso","year":"2003","journal-title":"FASEB J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ana.10614","article-title":"Minocycline and doxycycline are not beneficial in a model of Huntington&apos;s disease.","volume":"54","author":"DL Smith","year":"2003","journal-title":"Ann Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0014-5793(00)02380-2","article-title":"Anti-amyloidogenic activity of tetracyclines: studies in vitro.","volume":"487","author":"G Forloni","year":"2001","journal-title":"FEBS Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.251341998","article-title":"Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson&apos;s disease.","volume":"98","author":"Y Du","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ana.21891","article-title":"Minocycline is protective in a mouse model of Huntington&apos;s disease.","volume":"54","author":"S Hersch","year":"2003","journal-title":"Ann Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/glia.20338","article-title":"Minocycline affects microglia activation, Abeta deposition, and behavior in APP -tg mice.","volume":"53","author":"TJ Seabrook","year":"2006","journal-title":"Glia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1096\/fj.05-4509com","article-title":"Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.","volume":"20","author":"I Cardoso","year":"2006","journal-title":"FASEB J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1128\/AAC.01467-05","article-title":"Efficacy of macrolides and telithromycin against leptospirosis in a hamster model.","volume":"50","author":"JE Moon","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1128\/AAC.46.3.848-853.2002","article-title":"Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosis.","volume":"46","author":"J Truccolo","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2567.2004.02074.x","article-title":"Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin.","volume":"114","author":"J Mohan","year":"2005","journal-title":"Immunology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/JVI.78.10.4999-5006.2004","article-title":"Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.","volume":"78","author":"K Doh-ura","year":"2004","journal-title":"J Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1128\/JVI.78.3.1281-1288.2004","article-title":"Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies.","volume":"78","author":"I Murakami-Kubo","year":"2004","journal-title":"J Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1098\/rstb.2000.0764","article-title":"The molecular biology of prion propagation.","volume":"356","author":"AR Clarke","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bmb\/66.1.99","article-title":"TSE strain variation.","volume":"66","author":"ME Bruce","year":"2003","journal-title":"Br Med Bull"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1099\/0022-1317-75-9-2499","article-title":"Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie.","volume":"75","author":"R Demaimay","year":"1994","journal-title":"J Gen Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/jcpa.1999.0338","article-title":"MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters.","volume":"122","author":"KT Adjou","year":"2000","journal-title":"J Comp Pathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1128\/JVI.73.4.3511-3513.1999","article-title":"Effectiveness of polyene antibiotics in treatment of transmissible spongiform encephalopathy in transgenic mice expressing Syrian hamster PrP only in neurons.","volume":"7","author":"R Demaimay","year":"1999","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.","volume":"65","author":"I Chopra","year":"2001","journal-title":"Microbiol Mol Biol Rev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0001888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:14:21Z","timestamp":1589019261000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0001888"}},"subtitle":[],"editor":[{"given":"Mark R.","family":"Cookson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,3,26]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0001888","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,26]]}}}