{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:24:52Z","timestamp":1791080692511,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T00:00:00Z","timestamp":1207699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0001970","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T21:37:14Z","timestamp":1207690634000},"page":"e1970","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":116,"title":["The Role of the Iron Transporter ABCB7 in Refractory Anemia with Ring Sideroblasts"],"prefix":"10.1371","volume":"3","author":[{"given":"Jacqueline","family":"Boultwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pellagatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nikpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena","family":"Pushkaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Fidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Cattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Littlewood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Malcovati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo G.","family":"Della Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"J\u00e4dersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Killick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristoteles","family":"Giagounidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hellstr\u00f6m-Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Wainscoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJM199905273402107","article-title":"Myelodysplasia.","volume":"340","author":"ML Heaney","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1182\/asheducation-2002.1.136","article-title":"Myelodysplastic syndromes.","author":"PL Greenberg","year":"2002","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1182\/blood-2002-07-2006","article-title":"Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia.","volume":"101","author":"M Cazzola","year":"2003","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.leukres.2005.06.015","article-title":"Usefulness and prognostic impact on survival of WHO reclassification in FAB low risk myelodyplastic syndromes.","volume":"30","author":"M Breccia","year":"2006","journal-title":"Leuk Res"},{"key":"ref5","first-page":"86","article-title":"The sideroblastic anemias.","volume":"7","author":"JD Hines","year":"1970","journal-title":"Semin Hematol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(70)90221-7","article-title":"Familial sideroblastic anaemia: problem of Xg and X chromosome inactivation.","volume":"2","author":"DJ Weatherall","year":"1970","journal-title":"Lancet"},{"key":"ref7","first-page":"5","article-title":"Multiple mechanisms for hereditary sideroblastic anemia.","volume":"48","author":"K Furuyama","year":"2002","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1182\/blood.V84.11.3915.bloodjournal84113915","article-title":"X-linked sideroblastic anemia: identification of the mutation in the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) in the original family described by Cooley.","volume":"84","author":"PD Cotter","year":"1994","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1182\/blood.V96.9.3256","article-title":"Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation.","volume":"96","author":"S Bekri","year":"2000","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/hmg\/8.5.743","article-title":"Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA\/A).","volume":"8","author":"R Allikmets","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s100380050051","article-title":"Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia.","volume":"43","author":"Y Shimada","year":"1998","journal-title":"J Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0014-5793(97)01414-2","article-title":"The ABC transporter Atm1p is required for mitochondrial iron homeostasis.","volume":"418","author":"G Kispal","year":"1997","journal-title":"FEBS Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1182\/blood-2006-04-015768","article-title":"Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.","volume":"109","author":"C Pondarre","year":"2007","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1182\/blood-2006-08-041632","article-title":"RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload.","volume":"109","author":"P Cavadini","year":"2007","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes.","volume":"51","author":"JM Bennett","year":"1982","journal-title":"Br J Haematol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1073\/pnas.0610477104","article-title":"Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.","volume":"104","author":"A Pellagatti","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1182\/blood-2002-06-1774","article-title":"Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors.","volume":"101","author":"R Tehranchi","year":"2003","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1182\/blood-2005-12-4769","article-title":"Gene expression profiles of CD34<sup>+<\/sup> cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.","volume":"108","author":"A Pellagatti","year":"2006","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.leukres.2006.06.005","article-title":"Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts).","volume":"31","author":"DP Steensma","year":"2007","journal-title":"Leuk Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1990","article-title":"Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.","volume":"39","author":"M Weber","year":"2007","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/ng1213","article-title":"Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).","volume":"34","author":"RJ Gibbons","year":"2003","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1128\/MCB.00772-07","article-title":"Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification.","volume":"27","author":"MH Warner","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.1128\/MCB.21.23.8203-8212.2001","article-title":"Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.","volume":"21","author":"NJ Krogan","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1073\/pnas.251672198","article-title":"Human Elongator facilitates RNA polymerase II transcription through chromatin.","volume":"99","author":"JH Kim","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.clpt.2006.08.013","article-title":"Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.","volume":"80","author":"M Oscarson","year":"2006","journal-title":"Clin Pharmacol Ther"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0001970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:56:43Z","timestamp":1588993003000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0001970"}},"subtitle":[],"editor":[{"given":"Mikhail V.","family":"Blagosklonny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,4,9]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0001970","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,9]]}}}