{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:20:13Z","timestamp":1791156013249,"version":"4.1.0"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T00:00:00Z","timestamp":1209513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002040","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T22:17:55Z","timestamp":1209507475000},"page":"e2040","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":192,"title":["Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH\u2013Oligomannose-3 Complex"],"prefix":"10.1371","volume":"3","author":[{"given":"Adinda","family":"Wellens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nani","family":"Van Gerven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Sl\u00e4tteg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Hernalsteens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lode","family":"Wyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Oscarson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"De Greve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hultgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bouckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.sbi.2007.06.011","article-title":"Combining sites of bacterial fimbriae.","volume":"17","author":"H De Greve","year":"2007","journal-title":"Curr Opin Struct Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1242\/jcs.114.22.4095","article-title":"Uroplakin Ia is the urothelial receptor for uropathogenic <italic>Escherichia coli<\/italic>: evidence from in vitro FimH binding.","volume":"114","author":"G Zhou","year":"2001","journal-title":"J Cell Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1073\/pnas.0736473100","article-title":"Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance, to uropathogenic <italic>Escherichia coli<\/italic>.","volume":"100","author":"JD Schilling","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mib.2005.12.012","article-title":"Uropathogenic <italic>Escherichia coli<\/italic> as a model of host-parasite interaction.","volume":"9","author":"C Svanborg","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.282.5393.1494","article-title":"Induction and evasion of host defenses by type 1-piliated uropathogenic <italic>Escherichia coli<\/italic>.","volume":"282","author":"MA Mulvey","year":"1998","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/emboj\/19.12.2803","article-title":"Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.","volume":"19","author":"JJ Martinez","year":"2000","journal-title":"EMBO J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1073\/pnas.97.16.8829","article-title":"Bad bugs and beleaguered bladders: Interplay between uropathogenic <italic>Escherichia coli<\/italic> and innate host defenses.","volume":"97","author":"MA Mulvey","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1073\/pnas.0602136103","article-title":"Mechanisms of uropathogenic <italic>Escherichia coli<\/italic> persistence and eradication from the urinary tract.","volume":"103","author":"IU Mysorekar","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1084550","article-title":"Intracellular bacterial biofilm-like pods in urinary tract infections.","volume":"301","author":"GG Anderson","year":"2003","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1128\/IAI.00355-06","article-title":"Maturation of intracellular <italic>Escherichia coli<\/italic> communities requires SurA.","volume":"74","author":"SS Justice","year":"2006","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"19884","DOI":"10.1073\/pnas.0606329104","article-title":"Filamentation by <italic>Escherichia coli<\/italic> subverts innate defenses during urinary tract infection.","volume":"103","author":"SS Justice","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/IAI.69.7.4572-4579.2001","article-title":"Establishment of a persistent <italic>Escherichia coli<\/italic> reservoir during the acute phase of a bladder infection.","volume":"69","author":"MA Mulvey","year":"2001","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0924-8579(02)00098-5","article-title":"Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic <italic>Escherichia coli<\/italic>.","volume":"19","author":"JD Schilling","year":"2002","journal-title":"Internatl J Antimicrob Ag"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1073\/pnas.0308125100","article-title":"Differentiation and developmental pathways of uropathogenic <italic>Escherichia coli<\/italic> in urinary tract pathogenesis.","volume":"101","author":"SS Justice","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/IAI.01123-06","article-title":"<italic>Escherichia coli<\/italic> from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation.","volume":"75","author":"CK Garofalo","year":"2007","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1111\/j.1462-5822.2007.00952.x","article-title":"Development of intracellular bacterial communities of uropathogenic <italic>Escherichia coli<\/italic> depends on type 1 pili.","volume":"9","author":"KJ Wright","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nm1572","article-title":"Cyclic AMP-regulated exocytosis of <italic>Escherichia coli<\/italic> from infected bladder epithelial cells.","volume":"13","author":"BL Bishop","year":"2007","journal-title":"Nat Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1600-0854.2003.00156.x","article-title":"The uroepithelium: not just a passive barrier.","volume":"5","author":"G Apodaca","year":"2004","journal-title":"Traffic"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm0507-531","article-title":"Flushing bacteria out of the bladder.","volume":"13","author":"DS Eto","year":"2007","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1462-5822.2006.00691.x","article-title":"Actin-gated intracellular growth and resurgence of uropathogenic <italic>Escherichia coli<\/italic>.","volume":"8","author":"DS Eto","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1086\/315258","article-title":"Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic <italic>Escherichia coli<\/italic>.","volume":"181","author":"S Langermann","year":"2000","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bbagen.2005.12.008","article-title":"Carbohydrates as future anti-adhesion drugs for infectious diseases.","volume":"1760","author":"N Sharon","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0008-6215(83)88019-7","article-title":"Carbohydrate specificity of the surface lectins of <italic>Escherichia coli, Klebsiella pneumoniae<\/italic> and <italic>Salmonella typhimurium<\/italic>.","volume":"120","author":"N Firon","year":"1983","journal-title":"Carbohydr Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/IAI.52.2.428-436.1986","article-title":"Oligomannoside-type glycopeptides inhibiting adhesion of <italic>Escherichia coli<\/italic> strains mediated by type 1 pili: preparation of potent inhibitors from plant glycoproteins.","volume":"52","author":"JR Neeser","year":"1986","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-5793(87)80654-3","article-title":"Bacterial Lectins, cell-cell recognition and infectious disease.","volume":"217","author":"N Sharon","year":"1987","journal-title":"FEBS Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1365-2958.2006.05352.x","article-title":"The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of <italic>Escherichia coli<\/italic> pathotypes.","volume":"61","author":"J Bouckaert","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"17880","DOI":"10.1074\/jbc.272.28.17880","article-title":"Diversity of the Escherichia coli type 1 fimbrial lectin. Differential binding to mannosides and uroepithelial cells.","volume":"272","author":"EV Sokurenko","year":"1997","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"37707","DOI":"10.1074\/jbc.M501249200","article-title":"The distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts.","volume":"280","author":"MJ Duncan","year":"2005","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"23437","DOI":"10.1074\/jbc.M702037200","article-title":"Interdomain interaction in the FimH adhesin of <italic>Escherichia coli<\/italic> regulates the affinity to mannose.","volume":"282","author":"P Aprikian","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0092-8674(02)00796-1","article-title":"Bacterial adhesion to target cells enhanced by shear force.","volume":"109","author":"WE Thomas","year":"2002","journal-title":"Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"16656","DOI":"10.1074\/jbc.M511496200","article-title":"Catch bond-mediated adhesion without a shear threshold-Trimannose versus monomannose interactions with the FimH adhesin of <italic>Escherichia coli<\/italic>.","volume":"281","author":"LM Nilsson","year":"2006","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1074\/jbc.M008610200","article-title":"Tamm-Horsfall protein binds to type 1 fimbriated <italic>Escherichia coli<\/italic> and prevents <italic>Escherichia coli<\/italic> from binding to uroplakin Ia and Ib receptors.","volume":"276","author":"J Pak","year":"2001","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1371\/journal.ppat.0030100","article-title":"Integrin-mediated host cell invasion by type 1-piliated uropathogenic <italic>Escherichia coli<\/italic>.","volume":"3","author":"DS Eto","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/jmbi.2002.5442","article-title":"Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle.","volume":"317","author":"G Min","year":"2002","journal-title":"J Mol Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/bj3550013","article-title":"Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition.","volume":"355","author":"FX Liang","year":"2001","journal-title":"Biochem J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0854.2006.00515.x","article-title":"Tetraspanins as regulators of protein trafficking.","volume":"8","author":"F Berditchevski","year":"2007","journal-title":"Traffic"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14644","DOI":"10.1074\/jbc.M600877200","article-title":"Distinct glycan structures of uroplakins Ia and Ib: Structural basis for the selective binding of FimH adhesin to uroplakin Ia4.","volume":"281","author":"B Xie","year":"2006","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.18388\/abp.2002_3808","article-title":"The structure of the oligosaccharides of alpha3beta1 integrin from human ureter epithelium (HCV29) cell line.","volume":"49","author":"A Litynska","year":"2002","journal-title":"Acta Biochim Pol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1046\/j.1432-1033.2003.03938.x","article-title":"Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line.","volume":"271","author":"F Foulquier","year":"2004","journal-title":"Eur J Biochem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0140-6736(88)90868-9","article-title":"New type of adhesive specificity revealed by oligosaccharide probes in <italic>Escherichia coli<\/italic> from patients with urinary tract infection.","volume":"2","author":"IJ Rosenstein","year":"1988","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10719-005-2142-z","article-title":"N-Glycans carried by Tamm-Horsfall glycoprotein have a crucial role in the defense against urinary tract diseases.","volume":"22","author":"F Serafini-Cessi","year":"2005","journal-title":"Glycoconjugate J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1067\/mda.2003.7","article-title":"Epidemiology of urinary tract infections: Incidence, morbidity, and economic costs.","volume":"49","author":"B Foxman","year":"2003","journal-title":"Dis Mon"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2337\/diacare.25.8.1405","article-title":"Adherence of type 1-fimbriated <italic>Escherichia coli<\/italic> to uroepithelial cells-More in diabetic women than in control subjects.","volume":"25","author":"SE Geerlings","year":"2002","journal-title":"Diabetes Care"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0924-8579(02)00090-0","article-title":"Pathogenesis of bacteriuria in women with diabetes mellitus.","volume":"19","author":"SE Geerlings","year":"2002","journal-title":"Internatl J Antimicrob Ag"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1016\/S0021-9258(19)43529-1","article-title":"Mannose-containing trisaccharide isolated from urines of 3 patients with mannosidosis.","volume":"248","author":"NE Norden","year":"1973","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00284-005-0501-4","article-title":"High prevalence of multidrug resistance and random distribution of mobile genetic elements among uropathogenic <italic>Escherichia coli<\/italic> (UPEC) of the four major phylogenetic groups.","volume":"53","author":"M Rijavec","year":"2006","journal-title":"Curr Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2958.2004.04415.x","article-title":"Receptor binding studies disclose a novel class of high-affinity inhibitors of the <italic>Escherichia coli<\/italic> FimH adhesin.","volume":"55","author":"J Bouckaert","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0008-6215(79)80002-6","article-title":"The crystal and molecular structure of <italic>O<\/italic>-\u03b1-d-mannopyranosyl-(1-3)-<italic>O<\/italic>-\u03b2- d-mannopyranosyl-(1-4)-2-acetamido-2-deoxy-\u03b1-d-glucopyranose.","volume":"76","author":"V Warin","year":"1979","journal-title":"Carbohydrate Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/cr990368i","article-title":"Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling.","volume":"102","author":"MR Wormald","year":"2002","journal-title":"Chem Rev"},{"key":"ref50","first-page":"71","article-title":"Oligosaccharide conformation in protein\/glycan crystalline complexes, Adv Biophys Chem","volume":"3","author":"A Imberty","year":"1993"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state.","volume":"372","author":"E Krissinel","year":"2007","journal-title":"J Mol Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1126\/science.285.5430.1061","article-title":"X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic <italic>Escherichia coli<\/italic>.","volume":"285","author":"D Choudhury","year":"1999","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1046\/j.1365-2958.2002.02915.x","article-title":"Structural basis of tropism of <italic>Escherichia coli<\/italic> to the bladder during urinary tract infection.","volume":"44","author":"C-S Hung","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1128\/JB.00899-06","article-title":"Weak rolling adhesion enhances bacterial surface colonization.","volume":"189","author":"BN Anderson","journal-title":"J Bacteriol"},{"key":"ref55","first-page":"88","article-title":"Prevention of colonization of the urinary-tract by blocking bacterial adherence with methyl-alpha-D-mannopyranoside.","volume":"15","author":"M Aronson","year":"1979","journal-title":"Israel J Med Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1128\/AEM.72.4.3005-3010.2006","article-title":"Elevated shear stress protects <italic>Escherichia coli<\/italic> cells adhering to surfaces via catch bonds from detachment by soluble inhibitors.","volume":"72","author":"LM Nilsson","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1074\/jbc.M308821200","article-title":"Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated <italic>Escherichia coli<\/italic>.","volume":"279","author":"D Cavallone","year":"2004","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1128\/IAI.72.4.1929-1938.2004","article-title":"Immunoglobulin-mediated agglutination of and biofilm formation by <italic>Escherichia coli<\/italic> K-12 require the type 1 pilus fiber.","volume":"72","author":"PE Orndorff","year":"2004","journal-title":"Infect Immun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.1073\/pnas.0605399103","article-title":"Broad-spectrum biofilm inhibition by a secreted bacterial polysaccharide.","volume":"103","author":"J Valle","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0969-2126(96)00147-5","article-title":"Phi\/psi-chology: Ramachandran revisited.","volume":"4","author":"GJ Kleywegt","year":"1996","journal-title":"Structure"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/cmdc.200700063","article-title":"Mannosylated G(0) dendrimers with nanomolar affinities to <italic>Escherichia coli<\/italic> FimH.","volume":"2","author":"M Touaibia","year":"2007","journal-title":"ChemMedChem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode.","volume":"276","author":"Z Otwinowski","year":"1997","journal-title":"Methods Enzymol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1107\/S0021889897006766","article-title":"MOLREP: An automated program for molecular replacement.","author":"A Vagin","year":"1997","journal-title":"J Appl Crystallogr"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography &amp; NMR system: A new software suite for macromolecular structure determination.","volume":"54","author":"AT Brunger","year":"1998","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method.","volume":"53","author":"GN Murshudov","year":"1997","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref66","article-title":"TURBO-FRODO: Molecular Graphics Program for Silicon Graphics. IRIS 4D Series, version Bio-Graphics, Marseille, France.","author":"C Cambillau","year":"1992"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics.","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: phi, psi and Cbeta deviation.","volume":"50","author":"SC Lovell","year":"2003","journal-title":"Proteins"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0076-6879(97)77034-4","article-title":"Collaborative computational project, number 4: Providing programs for protein crystallography.","volume":"277","author":"EJ Dodson","year":"1997","journal-title":"Methods Enzymol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/jmbi.1994.1334","article-title":"Satisfying hydrogen bonding potential in proteins.","volume":"238","author":"IK McDonald","year":"1994","journal-title":"J Mol Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/j.1365-2958.1991.tb00790.x","article-title":"Type 1 fimbriae mutants of <italic>Escherichia coli<\/italic> K12: characterization of recognized afimbriate strains and construction of new fim deletion mutants.","volume":"5","author":"IC Blomfield","year":"1991","journal-title":"Mol Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/jb.165.3.1033-1036.1986","article-title":"The genetic determinant of adhesive function in type 1 fimbriae of <italic>Escherichia coli<\/italic> is distinct from the gene encoding the fimbrial subunit.","volume":"165","author":"FC Minion","year":"1989","journal-title":"J Bacteriol"}],"updated-by":[{"DOI":"10.1371\/annotation\/ea59d179-0a71-4836-86f0-8d375f5df089","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T00:00:00Z","timestamp":1212969600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T05:25:04Z","timestamp":1631165104000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002040"}},"subtitle":[],"editor":[{"given":"Shuguang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,4,30]]},"references-count":72,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002040","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,30]]}}}