{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:55:27Z","timestamp":1791255327685,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002206","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T16:11:25Z","timestamp":1211386285000},"page":"e2206","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Fibrinogen Binding Sites P336 and Y338 of Clumping Factor A Are Crucial for Staphylococcus aureus Virulence"],"prefix":"10.1371","volume":"3","author":[{"given":"Elisabet","family":"Josefsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Tarkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1128\/IAI.70.9.4987-4996.2002","article-title":"Virulent combinations of adhesin and toxin genes in natural populations of <italic>Staphylococcus aureus<\/italic>.","volume":"70","author":"SJ Peacock","year":"2002","journal-title":"Infect Immun"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1432-1033.1997.00416.x","article-title":"Characterization of the interaction between the <italic>Staphylococcus aureus<\/italic> clumping factor (ClfA) and fibrinogen.","volume":"247","author":"D McDevitt","year":"1997","journal-title":"Eur J Biochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2958.1994.tb00304.x","article-title":"Molecular characterization of the clumping factor (fibrinogen receptor) of <italic>Staphylococcus aureus<\/italic>.","volume":"11","author":"D McDevitt","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.micinf.2003.11.005","article-title":"Expression of staphylococcal clumping factor A impedes macrophage phagocytosis.","volume":"6","author":"N Palmqvist","year":"2004","journal-title":"Microb Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1574-6968.2006.00229.x","article-title":"Clumping factor A of <italic>Staphylococcus aureus<\/italic> inhibits phagocytosis by human polymorphonuclear leucocytes.","volume":"258","author":"J Higgins","year":"2006","journal-title":"FEMS Micriobiol Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2958.2005.04731.x","article-title":"Roles of fibrinogen, immunoglobulin and complement in platelet activation promoted by <italic>Staphylococcus aureus<\/italic> clumping factor A.","volume":"57","author":"A Loughman","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2958.2002.02935.x","article-title":"Multiple mechanisms for the activation of human platelet aggregation by <italic>Staphylococcus aureus<\/italic>: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A.","volume":"44","author":"L \u00d3'Brien","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1086\/324430","article-title":"Protection against experimental <italic>Staphylococcus aureus<\/italic> arthritis by vaccination with clumping factor A, a novel virulence determinant.","volume":"184","author":"E Josefsson","year":"2001","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1086\/427663","article-title":"Fibronectin-binding proteins and fibrinogen-binding clumping factors play distinct roles in staphylococcal arthritis and systemic inflammation.","volume":"191","author":"N Palmqvist","year":"2005","journal-title":"J Inf Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1093\/emboj\/cdf619","article-title":"A novel variant of the immunoglobulin fold in surface adhesins of <italic>Staphylococcus aureus<\/italic>: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A.","volume":"21","author":"CCS Deivanayagam","year":"2002","journal-title":"The EMBO Journal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1128\/IAI.59.8.2615-2623.1991","article-title":"Experimental <italic>Staphylococcus aureus<\/italic> arthritis in mice.","volume":"59","author":"T Bremell","year":"1991","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1002\/art.1780390921","article-title":"Addition of corticosteroids to antibiotic treatment ameliorates the course of experimental <italic>Staphylococcus aureus<\/italic> arthritis.","volume":"39","author":"E Sakiniene","year":"1996","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1128\/IAI.65.7.2517-2521.1997","article-title":"Role of neutrophils in experimental septicemia and septic arthritis induced by <italic>Staphylococcus aureus<\/italic>.","volume":"65","author":"M Verdrengh","year":"1997","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4049\/jimmunol.172.6.3798","article-title":"Streptococcal M5 protein prevents neutrophil phagocytosis by interfering with CD11b\/CD18 receptor-mediated association and signaling.","volume":"172","author":"M Weineisen","year":"2004","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2958.2005.04913.x","article-title":"Binding of human plasma proteins to Streptococcus pyogenes M protein determines the location of opsonic and non-opsonic epitopes.","volume":"59","author":"C Sandin","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref16","first-page":"95","article-title":"Staphylococcal coagulase: mode of action and antigenicity.","volume":"6","author":"ES Duthie","year":"1952","journal-title":"J Gen Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/305709a0","article-title":"The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage.","volume":"305","author":"BN Kreiswirth","year":"1983","journal-title":"Nature"},{"key":"ref18","first-page":"433","article-title":"Molecular genetic analysis of staphylococcal virulence.","author":"TJ Foster","year":"1998"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6821","DOI":"10.1074\/jbc.273.12.6821","article-title":"The fibrinogen-binding MSCRAMM (clumping factor) of <italic>Staphylococcus aureus<\/italic> has a Ca<sup>2++<\/sup>-dependent inhibitory site.","volume":"273","author":"DP O'Connell","year":"1998","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2249.1999.00771.x","article-title":"Complement depletion aggravates Staphylococcus aureus septicaemia and septic arthritis.","volume":"115","author":"E Sakiniene","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","article-title":"Immunochemical quantitation of antigens by single radial immunodiffusion.","volume":"2","author":"G Mancini","year":"1965","journal-title":"Immunochemistry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1128\/IAI.60.7.2976-2985.1992","article-title":"Histopathological and serological progression of experimental <italic>Staphylococcus aureus<\/italic> arthritis.","volume":"60","author":"T Bremell","year":"1992","journal-title":"Infect Immun"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:05:06Z","timestamp":1589040306000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002206"}},"subtitle":[],"editor":[{"given":"Robin Charles","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,5,21]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002206","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,21]]}}}