{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:38:32Z","timestamp":1792521512116,"version":"4.5.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002267","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T22:48:03Z","timestamp":1211323683000},"page":"e2267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":207,"title":["Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase\/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD"],"prefix":"10.1371","volume":"3","author":[{"given":"Nathalie","family":"Busso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Karababa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Rolaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Van Gool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oberdan","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"De Smedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1359-6101(02)00018-7","article-title":"Cytokines and anti-cytokine biologicals in autoimmunity: present and future.","volume":"13","author":"ET Andreakos","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI19930","article-title":"Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.","volume":"113","author":"SH Jia","year":"2004","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/bies.10297","article-title":"Reconstructing eukaryotic NAD metabolism.","volume":"25","author":"A Rongvaux","year":"2003","journal-title":"Bioessays"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L","article-title":"Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.","volume":"32","author":"A Rongvaux","year":"2002","journal-title":"Eur J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1128\/MCB.14.2.1431","article-title":"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor.","volume":"14","author":"B Samal","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1097243","article-title":"Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.","volume":"307","author":"A Fukuhara","year":"2005","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.bbrc.2006.02.109","article-title":"TNF regulates cellular NAD+ metabolism in primary macrophages.","volume":"342","author":"J Iqbal","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1073\/pnas.022649799","article-title":"Human macrophage activation programs induced by bacterial pathogens.","volume":"99","author":"GJ Nau","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.294.5543.870","article-title":"The plasticity of dendritic cell responses to pathogens and their components.","volume":"294","author":"Q Huang","year":"2001","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/jme.0.0260107","article-title":"Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes.","volume":"26","author":"S Ognjanovic","year":"2001","journal-title":"J Mol Endocrinol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/rccm.200404-563OC","article-title":"Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury.","volume":"171","author":"SQ Ye","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4049\/jimmunol.178.3.1748","article-title":"Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.","volume":"178","author":"AR Moschen","year":"2007","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/ard.2005.046540","article-title":"Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.","volume":"65","author":"M Otero","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1002\/art.21942","article-title":"Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.","volume":"54","author":"MA Nowell","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1002\/art.22833","article-title":"Pre-B cell colony-enhancing factor\/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities.","volume":"56","author":"F Brentano","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nsmb1105","article-title":"Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.","volume":"13","author":"JA Khan","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jmb.2006.06.082","article-title":"Crystal structure of visfatin\/pre-B cell colony-enhancing factor 1\/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866.","volume":"362","author":"MK Kim","year":"2006","journal-title":"J Mol Biol"},{"key":"ref18","first-page":"1057","article-title":"WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells.","volume":"62","author":"K Wosikowski","year":"2002","journal-title":"Cancer Res"},{"key":"ref19","first-page":"7436","article-title":"FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.","volume":"63","author":"M Hasmann","year":"2003","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1158\/1078-0432.CCR-04-1399","article-title":"Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy.","volume":"11","author":"M Muruganandham","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00281-006-0012-9","article-title":"Inhibition of IL-1, IL-6, and TNF-alpha in immune-mediated inflammatory diseases.","volume":"27","author":"B Moller","year":"2006","journal-title":"Springer Semin Immunopathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1046\/j.1432-1327.2000.01187.x","article-title":"New functions of a long-known molecule. Emerging roles of NAD in cellular signaling.","volume":"267","author":"M Ziegler","year":"2000","journal-title":"Eur J Biochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature05486","article-title":"Sirtuins as potential targets for metabolic syndrome.","volume":"444","author":"L Guarente","year":"2006","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: insights into their biological function.","volume":"404","author":"S Michan","year":"2007","journal-title":"Biochem J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s00018-002-8527-2","article-title":"The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders.","volume":"59","author":"PO Hassa","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0300-483X(95)03202-Q","article-title":"Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity.","volume":"107","author":"RD LeClaire","year":"1996","journal-title":"Toxicology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1006932714982","article-title":"Newly discovered anti-inflammatory properties of the benzamides and nicotinamides.","volume":"193","author":"RW Pero","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.","volume":"279","author":"JR Revollo","year":"2004","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.318.5850.565b","article-title":"Retraction.","volume":"318","author":"A Fukuhara","year":"2007","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2007.09.003","article-title":"Nampt\/PBEF\/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.","volume":"6","author":"JR Revollo","year":"2007","journal-title":"Cell Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"ii43","DOI":"10.1136\/ard.62.suppl_2.ii43","article-title":"Metalloproteinases, inflammation, and rheumatoid arthritis.","volume":"62","author":"FF Mohammed","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2007.05.096","article-title":"Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway.","volume":"359","author":"M Tanaka","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MOG.0b013e32801b3c8f","article-title":"The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt\/PBEF\/visfatin in mammals.","volume":"23","author":"JR Revollo","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/2006-00005.Dinarello","article-title":"The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.","volume":"11","author":"F Leoni","year":"2005","journal-title":"Mol Med"},{"key":"ref35","first-page":"473","article-title":"Methotrexate in rheumatoid arthritis.","volume":"58","author":"J Swierkot","year":"2006","journal-title":"Pharmacol Rep"},{"key":"ref36","first-page":"313","article-title":"Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents.","volume":"11","author":"A Pogrebniak","year":"2006","journal-title":"Eur J Med Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.febslet.2006.06.052","article-title":"Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1.","volume":"580","author":"SK Bae","year":"2006","journal-title":"FEBS Lett"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.bbrc.2006.07.083","article-title":"Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism.","volume":"349","author":"K Segawa","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbrc.2007.03.105","article-title":"Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1\/2.","volume":"357","author":"SR Kim","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/01.bor.0000155361.83990.5b","article-title":"Hypoxia and angiogenesis in rheumatoid arthritis.","volume":"17","author":"PC Taylor","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"ref41","article-title":"Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients.","author":"YA Lee","year":"2007","journal-title":"Clin Rheumatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.berh.2006.05.004","article-title":"Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting.","volume":"20","author":"DJ Veale","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.175.4.1135","article-title":"Angiogenesis inhibition suppresses collagen arthritis.","volume":"175","author":"DJ Peacock","year":"1992","journal-title":"J Exp Med"},{"key":"ref44","first-page":"4853","article-title":"Antiangiogenic potency of FK866\/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.","volume":"23","author":"J Drevs","year":"2003","journal-title":"Anticancer Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/abio.1994.1511","article-title":"Single Extraction Method for the Spectrophotometric Quantification of Oxidized and Reduced Pyridine Nucleotides in Erythrocytes.","volume":"222","author":"TC Wagner","year":"1994","journal-title":"Analytical Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T08:17:35Z","timestamp":1540369055000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002267"}},"subtitle":[],"editor":[{"given":"Jacques","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,5,21]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002267","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,21]]}}}