{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:37:40Z","timestamp":1773801460165,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2008,7,2]],"date-time":"2008-07-02T00:00:00Z","timestamp":1214956800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002578","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T23:15:52Z","timestamp":1214954152000},"page":"e2578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":94,"title":["IGF-1, IGFBP-1, and IGFBP-3 Polymorphisms Predict Circulating IGF Levels but Not Breast Cancer Risk: Findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)"],"prefix":"10.1371","volume":"3","author":[{"given":"Alpa V.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Canzian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Le Marchand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Thun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine D.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Buring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia E.","family":"Calle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Chanock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francoise","family":"Clavel-Chapelon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miren","family":"Dorronsoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Dossus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Haiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian E.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hoover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence N.","family":"Kolonel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Linseisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiliv","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Manjer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra H. M.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm C.","family":"Pike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Riboli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel O.","family":"Stram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tjonneland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth C.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Trichopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina G.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather Spencer","family":"Feigelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2008,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1677\/erc.0.0080197","article-title":"The IGF system and breast cancer.","volume":"8","author":"D Sachdev","year":"2001","journal-title":"Endocrine Related Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1009580913795","article-title":"IGFs and IGFBPs in the normal mammary gland and in breast cancer.","volume":"5","author":"TL Wood","year":"2000","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000184186","article-title":"Insulin-like growth factor binding proteins in the human circulation: a review.","volume":"42","author":"RC Baxter","year":"1994","journal-title":"Hormone Research"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.ejca.2005.04.023","article-title":"Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer.","volume":"41","author":"AM Burger","year":"2005","journal-title":"European Journal of Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1009559014703","article-title":"IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.","volume":"5","author":"DL Hadsell","year":"2000","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1158\/1055-9965.2.14.1","article-title":"Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.","volume":"14","author":"O Fletcher","year":"2005","journal-title":"Cancer Epidemiology, Biomarkers, & Prevention"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/sj.bjc.6602471","article-title":"A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk.","volume":"92","author":"NE Allen","year":"2005","journal-title":"British Journal of Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.bjc.6602936","article-title":"Polymorphisms of genes coding for insulin-like growth factor I and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.","volume":"94","author":"F Canzian","year":"2006","journal-title":"British Journal of Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1158\/1055-9965.EPI-06-0361","article-title":"Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: The Multiethnic Cohort.","volume":"15","author":"I Cheng","year":"2006","journal-title":"Cancer Epidemiology, Biomarkers, & Prevention"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1210\/jc.2007-0887","article-title":"Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.","volume":"92","author":"M Johansson","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/1055-9965.EPI-05-0625","article-title":"IGF-I genetic variation and breast cancer: the Multiethnic Cohort.","volume":"15","author":"VW Setiawan","year":"2006","journal-title":"Cancer Epidemiology, Biomarkers, & Prevention"},{"key":"ref12","article-title":"Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density.","author":"M Verheus","year":"2007","journal-title":"Breast Cancer Res Treat (epub ahead of print)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nrc1754","article-title":"A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.","volume":"5","author":"DJ Hunter","year":"2005","journal-title":"Nature Reviews Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/cncr.10197","article-title":"The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics.","volume":"94","author":"EE Calle","year":"2002","journal-title":"Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1079\/PHN2002394","article-title":"European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection.","volume":"5","author":"E Riboli","year":"2002","journal-title":"Public Health Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrc1608","article-title":"The Nurses' Health Study: lifestyle and health among women.","volume":"5","author":"GA Colditz","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/152460900318911","article-title":"Baseline characteristics of participants in the Women's Health Study.","volume":"9","author":"KM Rexrode","year":"2000","journal-title":"J Womens Health Gend Based Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/oxfordjournals.aje.a010213","article-title":"A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics.","volume":"151","author":"LN Kolonel","year":"2000","journal-title":"Am J Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"349S","DOI":"10.1016\/S0197-2456(00)00101-X","article-title":"Etiologic and early marker studies in the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial.","volume":"21","author":"RB Hayes","year":"2000","journal-title":"Control Clin Trials"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/jnci\/djj013","article-title":"Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.","volume":"98","author":"I Cheng","year":"2006","journal-title":"Journal of the National Cancer Institute"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome.","volume":"296","author":"SB Gabriel","year":"2002","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000071807","article-title":"Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study.","volume":"55","author":"DO Stram","year":"2003","journal-title":"Hum Hered"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"D528","DOI":"10.1093\/nar\/gkh005","article-title":"SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes.","volume":"32","author":"PB Packer","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjc.6600728","article-title":"IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii\/Los Angeles multiethnic cohort.","volume":"88","author":"K DeLellis","year":"2003","journal-title":"Br J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1677\/erc.1.01150","article-title":"IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).","volume":"13","author":"S Rinaldi","year":"2006","journal-title":"Endocr Relat Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1158\/1055-9965.EPI-04-0561","article-title":"Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk.","volume":"14","author":"ES Schernhammer","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000057986","article-title":"Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals.","volume":"53","author":"D Zaykin","year":"2002","journal-title":"Human Heredity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1158\/0008-5472.CAN-05-3574","article-title":"Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohorts.","volume":"66","author":"HS Feigelson","year":"2006","journal-title":"Cancer Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ijc.11358","article-title":"Polymorphic variation at the -202 locus in IGFBP3: influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk.","volume":"107","author":"ES Schernhammer","year":"2003","journal-title":"International Journal of Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10549-006-9403-9","article-title":"Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States.","volume":"104","author":"ML Slattery","year":"2007","journal-title":"Breast Cancer Research and Treatment"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10549-005-2417-x","article-title":"Polymorphisms in the IGF-1 and IGFBP-3 promoter and the risk of breast cancer.","volume":"92","author":"K Wagner","year":"2005","journal-title":"Breast Cancer Research and Treatment"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T01:49:42Z","timestamp":1684460982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002578"}},"subtitle":[],"editor":[{"given":"Florian","family":"Kronenberg","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2008,7,2]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2008,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002578","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,2]]}}}