{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:54:34Z","timestamp":1790978074352,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T00:00:00Z","timestamp":1216771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002742","type":"journal-article","created":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T21:40:08Z","timestamp":1216762808000},"page":"e2742","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["Interaction of Hyperalgesia and Sensory Loss in Complex Regional Pain Syndrome Type I (CRPS I)"],"prefix":"10.1371","volume":"3","author":[{"given":"Volker","family":"Huge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Lauchart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"F\u00f6rderreuther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Kaufhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Valet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz Christina","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Magerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(95)00110-E","article-title":"Reflex sympathetic dystrophy: changing concepts and taxonomy.","volume":"63","author":"M Stanton-Hicks","year":"1995","journal-title":"Pain"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3959(99)00011-1","article-title":"External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria. International Association for the Study of Pain.","volume":"81","author":"S Bruehl","year":"1999","journal-title":"Pain"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0304-3959(01)00332-3","article-title":"Quantitative sensory testing, neurophysiological and psychological examination in patients with complex regional pain syndrome and hemisensory deficits.","volume":"93","author":"O Rommel","year":"2001","journal-title":"Pain"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00002508-199809000-00013","article-title":"Central nervous system abnormalities in complex regional pain syndrome (CRPS): clinical and quantitative evidence of medullary dysfunction.","volume":"14","author":"M Thimineur","year":"1998","journal-title":"Clin J Pain"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pain.2004.08.001","article-title":"Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-Type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat.","volume":"112","author":"TJ Coderre","year":"2004","journal-title":"Pain"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejpain.2006.10.005","article-title":"Behavioral and sensory changes after direct ischemia-reperfusion injury in rats.","volume":"11","author":"J Ludwig","year":"2007","journal-title":"Eur J Pain"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0140-6736(93)92877-V","article-title":"Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients.","volume":"342","author":"PH Veldman","year":"1993","journal-title":"Lancet"},{"key":"ref8","first-page":"220","article-title":"Causalgia and other reflex sympathetic dystrophies.","author":"JJ Bonica","year":"1990"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3959(01)00387-6","article-title":"Complex regional pain syndrome: are there distinct subtypes and sequential stages of the syndrome?","volume":"95","author":"S Bruehl","year":"2002","journal-title":"Pain"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1212\/WNL.57.12.2179","article-title":"The important role of neuropeptides in complex regional pain syndrome.","volume":"57","author":"F Birklein","year":"2001","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neulet.2006.04.007","article-title":"Exaggeration of tissue trauma induces signs and symptoms of acute CRPS I, however displays distinct differences to experimental CRPS II.","volume":"402","author":"G Gradl","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2005.09.036","article-title":"Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy).","volume":"120","author":"AL Oaklander","year":"2006","journal-title":"Pain"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pain.2005.10.035","article-title":"Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome.","volume":"120","author":"PJ Albrecht","year":"2006","journal-title":"Pain"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1212\/01.WNL.0000098939.02752.8E","article-title":"Patterns of cortical reorganization in complex regional pain syndrome.","volume":"61","author":"C Maihofner","year":"2003","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1212\/WNL.61.4.515","article-title":"Bilateral motor cortex disinhibitionin complex regional pain syndrome (CRPS) type I of the hand.","volume":"61","author":"P Schwenkreis","year":"2003","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.20394","article-title":"Sensorimotor retuning [corrected] in complex regional pain syndrome parallels pain reduction.","volume":"57","author":"B Pleger","year":"2005","journal-title":"Ann Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/375482a0","article-title":"Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.","volume":"375","author":"H Flor","year":"1995","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1474-4422(03)00557-X","article-title":"Complex regional pain syndrome: mystery explained?","volume":"2","author":"W Janig","year":"2003","journal-title":"The Lancet Neurology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/","article-title":"Neurological findings in complex regional pain syndromes\u2013analysis of 145 cases.","volume":"101","author":"F Birklein","year":"2000","journal-title":"Acta Neurol Scand"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values.","volume":"123","author":"R Rolke","year":"2006","journal-title":"Pain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejpain.2005.02.003","article-title":"Quantitative sensory testing: a comprehensive protocol for clinical trials.","volume":"10","author":"R Rolke","year":"2006","journal-title":"European Journal of Pain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/brain\/115.3.893","article-title":"Quantitative somatosensory thermotest. A key method for functional evaluation of small calibre afferent channels.","volume":"115","author":"R Verdugo","year":"1992","journal-title":"Brain"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/brain\/122.2.239","article-title":"Paradoxical heat sensation in healthy subjects: peripherally conducted by A{delta} or C fibres?","volume":"122","author":"E Susser","year":"1999","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/oxfordjournals.aje.a112455","article-title":"Assessing depressive symptoms in five psychiatric populations: a validation study.","volume":"106","author":"MM Weissman","year":"1977","journal-title":"Am J Epidemiol"},{"key":"ref25","article-title":"Allgemeine Depressionsskala (ADS).","author":"M Hautzinger","year":"1993"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00002508-199706000-00011","article-title":"Assessing depression among persons with chronic pain using the Center for Epidemiological Studies-Depression Scale and the Beck Depression Inventory: a comparative analysis.","volume":"13","author":"ME Geisser","year":"1997","journal-title":"Clin J Pain"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pain.2004.09.030","article-title":"Evidence for cortical hyperexcitability of the affected limb representation area in CRPS: a psychophysical and transcranial magnetic stimulation study.","volume":"113","author":"E Eisenberg","year":"2005","journal-title":"Pain"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pain.2007.07.031","article-title":"Differential expression patterns of cytokines in complex regional pain syndrome.","volume":"132","author":"N \u00dc\u00e7eyler","year":"2007","journal-title":"Pain"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02267817","article-title":"Pattern of autonomic dysfunction in time course of complex regional pain syndrome.","volume":"8","author":"F Birklein","year":"1998","journal-title":"Clin Auton Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1017\/S0140525X97271487","article-title":"Sympathetic nervous system and pain: a clinical reappraisal.","volume":"20","author":"H Blumberg","year":"1997","journal-title":"Behav Brain Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"843s","DOI":"10.4049\/jimmunol.135.2.843","article-title":"The contribution of neurogenic inflammation in experimental arthritis.","volume":"135","author":"JD Levine","year":"1985","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0304-3959(00)00445-0","article-title":"Facilitated neurogenic inflammation in complex regional pain syndrome.","volume":"91","author":"M Weber","year":"2001","journal-title":"Pain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia.","volume":"38","author":"RD Treede","year":"1992","journal-title":"Prog Neurobiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/brain\/awh134","article-title":"Topical menthol\u2013a human model for cold pain by activation and sensitization of C nociceptors.","volume":"127","author":"G Wasner","year":"2004","journal-title":"Brain"},{"key":"ref35","first-page":"59","article-title":"Peripheral somatosensory abnormalities - pathology and pathophysiology.","author":"AL Oaklander","year":"2006"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/brain\/114.2.907","article-title":"Differential effect of compression-ischaemia block on warm sensation and heat-induced pain.","volume":"114 (Pt 2)","author":"D Yarnitsky","year":"1991","journal-title":"Brain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(84)90112-X","article-title":"Thermal sensibility changes during ischemic nerve block.","volume":"20","author":"H Fruhstorfer","year":"1984","journal-title":"Pain"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.8023144","article-title":"The thermal grill illusion: unmasking the burn of cold pain.","volume":"265","author":"AD Craig","year":"1994","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neulet.2004.02.025","article-title":"Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome.","volume":"359","author":"S Leis","year":"2004","journal-title":"Neurosci Lett"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/art.20184","article-title":"Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund&apos;s adjuvant-induced chronic arthritis model in the rat.","volume":"50","author":"Z Helyes","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1523\/JNEUROSCI.05-05-01380.1985","article-title":"Reflex neurogenic inflammation. I. Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury.","volume":"5","author":"JD Levine","year":"1985","journal-title":"J Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.410440513","article-title":"Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage.","volume":"44","author":"AL Oaklander","year":"1998","journal-title":"Ann Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ana.20048","article-title":"Unilateral nerve injury produces bilateral loss of distal innervation.","volume":"55","author":"AL Oaklander","year":"2004","journal-title":"Ann Neurol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1468-2982.2003.00581.x","article-title":"Subclinical sensory abnormalities in trigeminal neuralgia.","volume":"23","author":"VJ Sinay","year":"2003","journal-title":"Cephalalgia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/mus.20889","article-title":"Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies.","volume":"37","author":"E Vlckova-Moravcova","year":"2008","journal-title":"Muscle Nerve"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1468-1331.2006.01232.x","article-title":"Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy.","volume":"13","author":"S Loseth","year":"2006","journal-title":"Eur J Neurol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2377-7-21","article-title":"Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts.","volume":"7","author":"DD Atherton","year":"2007","journal-title":"BMC Neurol"},{"key":"ref48","article-title":"Sensory deficit in Parkinson&apos;s disease: evidence of a cutaneous denervation.","author":"M Nolano","year":"2008","journal-title":"Brain"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(98)00257-7","article-title":"Topographical features of cutaneous tactile hypoesthetic and hyperesthetic abnormalities in chronic pain.","volume":"81","author":"K Moriwaki","year":"1999","journal-title":"Pain"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1090-3801(02)00041-1","article-title":"The influence of experimental pain intensity in the local and referred pain area on somatosensory perception in the area of referred pain.","volume":"6","author":"E Kosek","year":"2002","journal-title":"European Journal of Pain"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2003.12.001","article-title":"Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects.","volume":"361","author":"W Magerl","year":"2004","journal-title":"Neurosci Lett"},{"key":"ref52","article-title":"Numbness in clinical and experimental pain - A cross-sectional study exploring the mechanisms of reduced tactile function.","author":"C Geber","year":"2008","journal-title":"Pain"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/S0140-6736(99)03746-0","article-title":"Contralateral thalamic perfusion in patients with reflex sympathetic dystrophy syndrome.","volume":"354","author":"M Fukumoto","year":"1999","journal-title":"Lancet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/74852","article-title":"Functional changes at periphery and cortex following dorsal root lesions in adult monkeys.","volume":"3","author":"C Darian-Smith","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuroimage.2006.03.045","article-title":"Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome.","volume":"32","author":"B Pleger","year":"2006","journal-title":"NeuroImage"},{"key":"ref56","first-page":"1","article-title":"Hyperalgesia and allodynia: taxonomy, assessment, and mechanisms.","author":"RD Treede","year":"2004"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T08:46:16Z","timestamp":1684485976000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002742"}},"subtitle":[],"editor":[{"given":"Allan","family":"Cyna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,7,23]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2008,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002742","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,23]]}}}