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A Jekyll and Hyde role for blood cells during wound repair.","volume":"127","author":"BM Stramer","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1385\/IR:36:1:237","article-title":"Deciphering the complexity of acute inflammation using mathematical models.","volume":"36","author":"Y Vodovotz","year":"2006","journal-title":"Immunol Res"},{"key":"ref68","first-page":"255","article-title":"Wound: the healing process.","volume":"9","author":"S Cockbill","year":"2002","journal-title":"Hospital Pharmacist"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound Healing-aiming for perfect skin regeneration.","volume":"276","author":"P Martin","year":"1997","journal-title":"Science"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0039-6109(05)70566-1","article-title":"General principles of wound healing.","volume":"77","author":"MB Witte","year":"1997","journal-title":"Surgical Clinics of North America"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0892-1997(02)00102-9","article-title":"Fibronectin:an interesting vocal fold protein.","volume":"16","author":"SD Hirschi","year":"2002","journal-title":"J Voice"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1067\/S0892-1997(03)00064-X","article-title":"Interstitial protein alterations in rabbit vocal fold with scar.","volume":"17","author":"SL Thibeault","year":"2003","journal-title":"J Voice"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0892-1997(02)00078-4","article-title":"Histologic and Rheologic characterization of vocal fold scarring.","volume":"16","author":"SL Thibeault","year":"2002","journal-title":"Journal of 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Am"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jbiomech.2003.11.007","article-title":"Modeling mechanical stresses as a factor in the etiology of benign vocal fold lesions.","volume":"37","author":"HE Gunter","year":"2004","journal-title":"Journal of Biomechanics"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/000348949810700711","article-title":"Finite modeling of vocal fold vibratioin in normal phonation and hyperfunctional dysphonia: implications for the pathogenesis of vocal nodules.","volume":"107","author":"JJ Jiang","year":"1998","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1121\/1.2000787","article-title":"Aerodynamic transfer of energy to the vocal folds.","volume":"118","author":"SL Thomson","year":"2005","journal-title":"J Acoust Soc Am"},{"key":"ref80","first-page":"275","article-title":"Transforming growth factor-b.","author":"AB Roberts","year":"1996"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1357-2725(96)00120-3","article-title":"Transforming growth factor betas and wound healing.","volume":"29","author":"S O'Kane","year":"1997","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"ref82","first-page":"1228","article-title":"Immunohistochemical detection of active transforming growth factor-b in situ using engineered tissue.","volume":"147","author":"MH Barcellos-Hoff","year":"1995","journal-title":"American Journal of Pathology"},{"key":"ref83","first-page":"275","article-title":"Immunocytochemical detection of latent TGF-b activation in cultured macrophages.","volume":"178","author":"H Chong","year":"1999","journal-title":"Journal of Cellular Physiology"},{"key":"ref84","first-page":"2142","article-title":"Regulation of transforming growth factor beta1 by nitric oxide.","volume":"59","author":"Y Vodovotz","year":"1999","journal-title":"Cancer Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00024382-200606001-00118","article-title":"In silico and in vivo studies modeling the aged acute inflammatory response.","volume":"25","author":"Y Vodovotz","year":"2006","journal-title":"Shock"},{"key":"ref86","article-title":"Simulating acute phonotrauma: a comparison of agent-based and equation-based models; 2006; Tokyo, Japan","author":"NYK Li"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s10620-005-3033-7","article-title":"Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology.","volume":"50","author":"DC Whitcomb","year":"2005","journal-title":"Dig Dis Sci"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1097\/01.CCM.0000142394.28791.C3","article-title":"In silico design of clinical trials: a method coming of age.","volume":"32","author":"G Clermont","year":"2004","journal-title":"Crit Care Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00024382-200116040-00006","article-title":"Agent-based computer simulation and sirs: building a bridge between basic science and clinical trials.","volume":"16","author":"G An","year":"2001","journal-title":"Shock"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jtbi.2004.04.044","article-title":"The dynamics of acute inflammation.","volume":"230","author":"R Kumar","year":"2004","journal-title":"J Theor Biol"},{"key":"ref91","article-title":"A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation.","author":"A Reynolds","year":"2006","journal-title":"J Theor Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1097\/01.CCM.0000139707.13729.7D","article-title":"In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling.","volume":"32","author":"G An","year":"2004","journal-title":"Critical Care Medicine"},{"key":"ref93","article-title":"A mathematical simulation of the inflammatory response to anthraz infection.","author":"R Kumar","journal-title":"Shock"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/000348949410300501","article-title":"Comparison of aerodynamic and electroglottographic parameters in evaluating clinically relevant voicing patterns.","volume":"103","author":"KL Peterson","year":"1994","journal-title":"Ann Otol Rhinol 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Regeneration"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/msg.2001.111167","article-title":"Wound healing: biologic features and approaches to maximize healing trajectories.","volume":"38","author":"MC Robson","year":"2001","journal-title":"Curr Probl Surg"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self.","volume":"296","author":"P Matzinger","year":"2002","journal-title":"Science"},{"key":"ref100","article-title":"Agent-based modeling of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta 1.","author":"Q Mi","journal-title":"Wound Repair and Regeneration"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/000348940611500311","article-title":"Quantitative and comparative studies of the vocal fold extracellular matrix II: collagen.","volume":"115","author":"MS Hahn","year":"2006","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1097\/00005537-200312000-00027","article-title":"Distribution of collagen in the lamina propria of the human vocal fold.","volume":"113","author":"EC Madruga de Melo","year":"2003","journal-title":"Laryngoscope"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/000348940611500612","article-title":"Collagen subtypes in human vocal folds.","volume":"115","author":"T Tateya","year":"2006","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/000348949610500706","article-title":"Immunohistochemical characterization of benign laryngeal lesions.","volume":"195","author":"MS Courey","year":"1996","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref105","first-page":"8","article-title":"Benign pathologic response of the larynx.","volume":"104","author":"SD Gray","year":"1995","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref106","first-page":"439","article-title":"Histopathological and immunohistochemical differentiation of epithelial alterations in vocal nodule comparing to polyps and to laryngeal edema.","volume":"70","author":"BMJ Neves","year":"2004","journal-title":"Brazillian Journal of Otolaryngology"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1939-7445.2001.tb00069.x","article-title":"Getting \u201cresults\u201d: the pattern-oriented approach to analyze natural systems with individual-based models.","volume":"14","author":"SF Railback","year":"2001","journal-title":"Natural Resource Modeling"}],"container-title":["PLoS 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