{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:56:48Z","timestamp":1792115808544,"version":"4.4.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002962","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T17:11:45Z","timestamp":1218561105000},"page":"e2962","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome"],"prefix":"10.1371","volume":"3","author":[{"given":"Robert H.","family":"Wallis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan C.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Kaisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar\u00e8ne","family":"Argoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin J.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Ria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ktorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Rorsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Bihoreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Gauguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.2337\/diab.37.12.1595","article-title":"Insulin Resistance in human disease.","volume":"37","author":"GM Reaven","year":"1988","journal-title":"Diabetes"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2337\/diab.44.4.369","article-title":"Diabetes and cardiovascular disease. The \u201ccommon soil\u201d hypothesis.","volume":"44","author":"MP Stern","year":"1995","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome.","volume":"365","author":"RH Eckel","year":"2005","journal-title":"Lancet"},{"key":"ref4","first-page":"1684","article-title":"The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes.","volume":"48","author":"R Kahn","year":"2005","journal-title":"Diabetologia"},{"key":"ref5","first-page":"1154","article-title":"The rat as a model physiological system.","author":"D Gauguier","year":"2006"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/physrev.2000.80.1.135","article-title":"Genetic analysis of inherited hypertension in the rat.","volume":"80","author":"JP Rapp","year":"2000","journal-title":"Physiol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1126\/science.1062117","article-title":"A genomic-systems biology map for cardiovascular function.","volume":"294","author":"M Stoll","year":"2001","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s00125-006-0396-z","article-title":"Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.","volume":"49","author":"K Argoud","year":"2006","journal-title":"Diabetologia"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ng0196-44","article-title":"Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.","volume":"12","author":"DM Brown","year":"1996","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1006\/geno.1997.4672","article-title":"Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM.","volume":"41","author":"WK Chung","year":"1997","journal-title":"Genomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng0196-31","article-title":"Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.","volume":"12","author":"J Galli","year":"1996","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ng0196-38","article-title":"Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.","volume":"12","author":"D Gauguier","year":"1996","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0896-429","article-title":"Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease.","volume":"13","author":"S Rubattu","year":"1996","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/geno.1999.5789","article-title":"Genetic dissection of \u201cOLETF,\u201d a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.","volume":"58","author":"TK Watanabe","year":"1999","journal-title":"Genomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1440-1681.2005.04196.x","article-title":"Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia\/dyslipidaemia\/obesity locus of Dmo1 in the OLETF rat.","volume":"32","author":"TK Watanabe","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1031","article-title":"Congenic mice: cutting tools for complex immune disorders.","volume":"3","author":"UC Rogner","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/73427","article-title":"Analysing complex genetic traits with chromosome substitution strains.","volume":"24","author":"H Nadeau","year":"2000","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00335-005-0168-y","article-title":"Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.","volume":"17","author":"SC Collins","year":"2006","journal-title":"Mamm Genome"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng1197-280","article-title":"Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains.","volume":"17","author":"P Markel","year":"1997","journal-title":"Nat Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1101\/gr.7.5.434","article-title":"A linkage map of the rat genome derived from three F2 crosses.","volume":"7","author":"MT Bihoreau","year":"1997","journal-title":"Genome Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00335-002-3058-6","article-title":"Marker Assisted Congenic Screening (MACS): A Database Tool for the Efficient Production and Characterisation of Congenic Lines.","volume":"14","author":"SC Collins","year":"2003","journal-title":"Mamm Genome"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00125-007-0738-5","article-title":"Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.","volume":"50","author":"AA Toye","year":"2007","journal-title":"Diabetologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/414788a","article-title":"Diabetes mellitus and genetically programmed defects in beta-cell function.","volume":"414","author":"GI Bell","year":"2001","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/eje.0.1400087","article-title":"L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide.","volume":"140","author":"P Thams","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.2337\/diabetes.48.12.2463","article-title":"Pathophysiological and genetic characterization of the major diabetes locus in GK rats.","volume":"48","author":"J Galli","year":"1999","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.2337\/db06-0796","article-title":"Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.","volume":"55","author":"C Granhall","year":"2006","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/hmg\/9.14.2149","article-title":"Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.","volume":"9","author":"H Fakhrai Rad","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.2337\/diabetes.51.7.2012","article-title":"The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.","volume":"51","author":"E Marion","year":"2002","journal-title":"Diabetes"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/5013","article-title":"Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats [see comments].","volume":"21","author":"TJ Aitman","year":"1999","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T04:09:35Z","timestamp":1557720575000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002962"}},"subtitle":[],"editor":[{"given":"Adrian","family":"Vella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,8,13]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002962","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,13]]}}}