{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:54:27Z","timestamp":1791176067456,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T00:00:00Z","timestamp":1219276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002985","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T21:14:42Z","timestamp":1219266882000},"page":"e2985","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":128,"title":["Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China"],"prefix":"10.1371","volume":"3","author":[{"given":"Hongjie","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhancheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nijuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzhao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuecheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longshan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbao","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longnv","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui Shan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Uyeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,8,21]]},"reference":[{"key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra0707279","article-title":"Update on avian influenza A (H5N1) virus infection in humans.","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa044021","article-title":"Probable person-to-person transmission of avian influenza A(H5N1).","volume":"352","author":"K Ungchusak","year":"2005","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1056\/NEJMoa060930","article-title":"Three Indonesian clusters of H5N1 virus infection in 2005.","volume":"355","author":"IN Kandun","year":"2006","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(08)60493-6","article-title":"Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China.","volume":"371","author":"H Wang","year":"2008","journal-title":"Lancet"},{"key":"ref6"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1126\/science.1115273","article-title":"Highly pathogenic H5N1 influenza virus infection in migratory birds.","volume":"309","author":"J Liu","year":"2005","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature03974","article-title":"Avian flu: H5N1 virus outbreak in migratory waterfowl.","volume":"436","author":"H Chen","year":"2005","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0140-6736(98)01182-9","article-title":"Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.","volume":"351","author":"KY Yuen","year":"1998","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(04)15595-5","article-title":"Re-emergence of fatal human influenza A subtype H5N1 disease.","volume":"363","author":"JS Peiris","year":"2004","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1056\/NEJMoa040419","article-title":"Avian influenza A (H5N1) in 10 patients in Vietnam.","volume":"350","author":"TH Tran","year":"2004","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1056\/NEJMoa044307","article-title":"Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma.","volume":"352","author":"MD de Jong","year":"2005","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3201\/eid1102.041061","article-title":"Human disease from influenza A(H5N1), Thailand, 2004.","volume":"11","author":"T Chotpitayasunondh","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3201\/eid1007.040415","article-title":"Atypical avian influenza (H5N1).","volume":"10","author":"A Apisarnthanarak","year":"2004","journal-title":"Emerging Infect Dis"},{"key":"ref15","first-page":"3","article-title":"Investigation of avian influenza (H5N1) outbreak in humans \u2013 Thailand, 2004.","volume":"55","author":"D Areechokchai","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1086\/519692","article-title":"Epidemiology of Cases of H5N1 Virus Infection in Indonesia, July 2005\u2013June 2006.","volume":"196","author":"ER Sedyaningsih","year":"2007","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcv.2007.04.010","article-title":"Influenza A\/H5N1 virus infection in humans in Cambodia.","volume":"39","author":"P Buchy","year":"2007","journal-title":"J Clin Virol"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.2807\/esm.11.05.00620-en","article-title":"Two clusters of human infection with influenza A\/H5N1 virus in the Republic of Azerbaijan, February\u2013March 2006.","volume":"11","author":"A Gilsdorf","year":"2006","journal-title":"Euro Surveill"},{"key":"ref19","first-page":"183","article-title":"Human avian influenza in Azerbaijan, February\u2013March 2006.","volume":"81","year":"2006","journal-title":"Wkly Epidemiol Rec"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1056\/NEJMoa060601","article-title":"Avian influenza A (H5N1) infection in eastern Turkey in 2006.","volume":"355","author":"AF Oner","year":"2006","journal-title":"N Engl J Med"},{"key":"ref21"},{"key":"ref22"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1128\/JCM.40.9.3256-3260.2002","article-title":"Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes.","volume":"40","author":"E Spackman","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref24","year":"2002"},{"key":"ref25"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jmv.10408","article-title":"Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin.","volume":"70","author":"I Stephesen","year":"2003","journal-title":"J Med Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0140-6736(05)67894-4","article-title":"The first confirmed human case of avian influenza A (H5N1) in Mainland China.","volume":"367","author":"H Yu","year":"2006","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1056\/NEJMc053524","article-title":"Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui province, China.","volume":"354","author":"Y Shu","year":"2006","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3201\/eid1307.061557","article-title":"Human influenza A(H5N1) cases, urban areas of People&apos;s Republic of China, 2005\u20132006.","volume":"13","author":"H Yu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(07)61515-3","article-title":"H5N1 infection of the respiratory tract and beyond: a molecular pathology study,","volume":"370","author":"J Gu","year":"2007","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1125548","article-title":"H5N1 Virus Attachment to Lower Respiratory Tract.","volume":"312","author":"D Van Riel","year":"2006","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3201\/eid1305.060572","article-title":"Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans.","volume":"13","author":"M Uiprasertkul","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.","volume":"12","author":"MD de Jong","year":"2006","journal-title":"Nat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1465-9921-6-135","article-title":"Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells.","volume":"6","author":"MC Chan","year":"2005","journal-title":"Repir Res"},{"key":"ref35","first-page":"41","article-title":"Update: WHO-confirmed human cases of avian influenza A(H5N1) infection, 25 November 2003\u201324 November 2006.","volume":"82","year":"2007","journal-title":"Wkly Epidemiol Rec"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1473-3099(06)70684-3","article-title":"WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus.","volume":"7","author":"HJ Sch\u00fcnemann","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"ref37"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMc070359","article-title":"Treatment with convalescent Plasma for Influenza A (H5N1) Infection,","volume":"357","author":"B Zhou","year":"2007","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.7326\/0003-4819-145-8-200610170-00139","article-title":"Meta-analysis: Convalescent blood products for Spanish influenza pneumonia: A future H5N1 treatment?","volume":"145","author":"TC Luke","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-7-43","article-title":"Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab&apos;)2 in mice.","volume":"7","author":"J Lu","year":"2006","journal-title":"Respir Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1465-9921-7-126","article-title":"Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice.","volume":"7","author":"BJ Hanson","year":"2006","journal-title":"Respir Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1371\/journal.pmed.0040178","article-title":"Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.","volume":"4(5)","author":"CP Simmons","year":"2007","journal-title":"PLoS Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T16:13:09Z","timestamp":1738339989000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002985"}},"subtitle":[],"editor":[{"given":"Joel Mark","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,8,21]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002985","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,21]]}}}