{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:37:17Z","timestamp":1790854637780,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0003340","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T19:19:31Z","timestamp":1222975171000},"page":"e3340","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Common and Unique Contributions of Decorin-Binding Proteins A and B to the Overall Virulence of Borrelia burgdorferi"],"prefix":"10.1371","volume":"3","author":[{"given":"Yanlin","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita V.","family":"Seemanaplli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"McShan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang Ting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.1988.tb31851.x","article-title":"Development of <italic>Borrelia burgdorferi<\/italic> in ixodid tick vectors.","volume":"539","author":"W Burgdorfer","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease.","volume":"345","author":"AC Steere","year":"2001","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/infdis\/163.2.419","article-title":"Infectivity of <italic>Borrelia burgdorferi<\/italic> relative to route of inoculation and genotype in laboratory mice.","volume":"163","author":"SW Barthold","year":"1991","journal-title":"J Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1128\/IAI.00897-07","article-title":"Both decorin-binding proteins A and B are critical for the overall virulence of <italic>Borrelia burgdorferi<\/italic>.","volume":"76","author":"Y Shi","year":"2008","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0952-7915(96)80038-0","article-title":"Immunity to Lyme disease: protection, pathology and persistence.","volume":"8","author":"KP Seiler","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1128\/IAI.63.9.3467-3472.1995","article-title":"Adherence of <italic>Borrelia burgdorferi<\/italic> to the proteoglycan decorin.","volume":"63","author":"BP Guo","year":"1995","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from <italic>Borrelia burgdorferi<\/italic>.","volume":"30","author":"BP Guo","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1128\/IAI.66.6.2674-2683.1998","article-title":"Decorin-binding protein of <italic>Borrelia burgdorferi<\/italic> is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis.","volume":"66","author":"KE Hagman","year":"1998","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1128\/IAI.66.6.2827-2835.1998","article-title":"Humoral immunity to <italic>Borrelia burgdorferi<\/italic> N40 decorin binding proteins during infection of laboratory mice.","volume":"66","author":"S Feng","year":"1998","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1128\/IAI.66.5.2143-2153.1998","article-title":"Active and passive immunity against <italic>Borrelia burgdorferi<\/italic> decorin binding protein A (DbpA) protects against infection.","volume":"66","author":"MS Hanson","year":"1998","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1128\/IAI.68.8.4759-4764.2000","article-title":"Decorin-binding protein A (DbpA) of <italic>Borrelia burgdorferi<\/italic> is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by <italic>B. burgdorferi<\/italic> in ticks.","volume":"68","author":"KE Hagman","year":"2000","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1073\/pnas.1231043100","article-title":"Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by <italic>Borrelia burgdorferi<\/italic>, the Lyme disease spirochete.","volume":"100","author":"JR Fischer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0002-9440(10)63359-7","article-title":"Protective niche for <italic>Borrelia burgdorferi<\/italic> to evade humoral immunity.","volume":"165","author":"FT Liang","year":"2004","journal-title":"Am J Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1172\/JCI11692","article-title":"Resistance to Lyme disease in decorin-deficient mice.","volume":"107","author":"EL Brown","year":"2001","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1128\/IAI.00740-06","article-title":"The <italic>dbpBA<\/italic> locus of <italic>Borrelia burgdorferi<\/italic> is not essential for infection of mice.","volume":"74","author":"Y Shi","year":"2006","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2180-8-82","article-title":"Assessment of decorin-binding protein A to the infectivity of <italic>Borrelia burgdorferi<\/italic> in the murine models of needle and tick infection.","volume":"8","author":"JS Blevins","year":"2008","journal-title":"BMC Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/IAI.00560-07","article-title":"Increasing the interaction of <italic>Borrelia burgdorferi<\/italic> with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination.","volume":"75","author":"Q Xu","year":"2007","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2958.2008.06264.x","article-title":"Essential protective role attributed to the surface lipoproteins of <italic>Borrelia burgdorferi<\/italic> against innate defences.","volume":"69","author":"Q Xu","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/IAI.72.10.5759-5767.2004","article-title":"<italic>Borrelia burgdorferi<\/italic> changes its surface antigenic expression in response to host immune responses.","volume":"72","author":"FT Liang","year":"2004","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1046\/j.1365-2958.2003.03452.x","article-title":"A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of <italic>Borrelia burgdorferi<\/italic> in a mammalian host.","volume":"48","author":"JE Purser","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/j.1365-2958.2006.05039.x","article-title":"<italic>Borrelia burgdorferi<\/italic> lipoproteins are secreted to the outer surface by default.","volume":"59","author":"RJ Schulze","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref22","article-title":"Modification of <italic>Borrelia burgdorferi<\/italic> to overproduce OspA or VlsE alters its infectious behavior.","author":"Q Xu","year":"2008","journal-title":"Microbiology in press"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1365-2958.2005.04759.x","article-title":"Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete.","volume":"57","author":"J Coburn","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tim.2007.06.003","article-title":"Hidden in plain sight: <italic>Borrelia burgdorferi<\/italic> and the extracellular matrix.","volume":"15","author":"FC Cabello","year":"2007","journal-title":"Trends Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1128\/IAI.00469-06","article-title":"Antibody-mediated disease remission in the mouse model of Lyme borreliosis.","volume":"74","author":"SW Barthold","year":"2006","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/JCM.20.6.1099-1101.1984","article-title":"Infection of Syrian hamsters with Lyme disease spirochetes.","volume":"20","author":"RC Johnson","year":"1984","journal-title":"J Clin Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1073\/pnas.93.15.7973","article-title":"Limited surface exposure of <italic>Borrelia burgdorferi<\/italic> outer surface lipoproteins.","volume":"93","author":"DL Cox","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2004.02.007","article-title":"<italic>Borrelia burgdorferi<\/italic> outer surface protein (<italic>osp<\/italic>) <italic>B<\/italic> expression independent of <italic>ospA<\/italic>.","volume":"37","author":"FT Liang","year":"2004","journal-title":"Microb Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1128\/IAI.71.8.4608-4613.2003","article-title":"The absence of linear plasmid 25 or 28-1 of <italic>Borrelia burgdorferi<\/italic> dramatically alters the kinetics of experimental infection via distinct mechanisms.","volume":"71","author":"M Labandeira-Rey","year":"2003","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1128\/IAI.73.11.7208-7215.2005","article-title":"Association of linear plasmid 28-1 with an arthritic phenotype of <italic>Borrelia burgdorferi<\/italic>.","volume":"73","author":"Q Xu","year":"2005","journal-title":"Infect Immun"},{"key":"ref31","first-page":"493","article-title":"A simple method of estimating fifty percent endpoint.","volume":"27","author":"LJ Reed","year":"1938","journal-title":"Am J Hygiene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1128\/IAI.00713-06","article-title":"Constitutive expression of outer surface protein C diminishes the ability of <italic>Borrelia burgdorferi<\/italic> to evade specific humoral immunity.","volume":"74","author":"Q Xu","year":"2006","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2958.2007.05636.x","article-title":"Identification of an <italic>ospC<\/italic> operator critical for immune evasion of <italic>Borrelia burgdorferi<\/italic>.","volume":"64","author":"Q Xu","year":"2007","journal-title":"Mol Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0003340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:03:51Z","timestamp":1588968231000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0003340"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,3]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,10,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0003340","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,3]]}}}