{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:52:11Z","timestamp":1788000731975,"version":"build-2784847793"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:00:00Z","timestamp":1223424000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0003371","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T19:17:14Z","timestamp":1223407034000},"page":"e3371","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Fetal and Neonatal Nicotine Exposure in Wistar Rats Causes Progressive Pancreatic Mitochondrial Damage and Beta Cell Dysfunction"],"prefix":"10.1371","volume":"3","author":[{"given":"Jennifer E.","family":"Bruin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Petre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Raha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/siny.2000.0025","article-title":"Perinatal complications associated with maternal tobacco use.","volume":"5","author":"RL Andres","year":"2000","journal-title":"Semin Neonatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1053\/sper.2002.34771","article-title":"Trends in smoking and overweight during pregnancy: prevalence, risks of pregnancy complications, and adverse pregnancy outcomes.","volume":"26","author":"S Cnattingius","year":"2002","journal-title":"Semin Perinatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/jmf.13.3.175.190","article-title":"Etiology and risk factors for placenta previa: an overview and meta-analysis of observational studies.","volume":"13","author":"AS Faiz","year":"2003","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2105\/AJPH.86.3.347","article-title":"Intrauterine growth retardation and premature delivery: the influence of maternal smoking and psychosocial factors.","volume":"86","author":"M Nordentoft","year":"1996","journal-title":"Am J Public Health"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0301-2115(00)00421-8","article-title":"Origins of fetal growth restriction.","volume":"92","author":"JS Robinson","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1053\/plac.1998.0377","article-title":"Cigarette smoking and pregnancy I: ovarian, uterine and placental effects.","volume":"20","author":"KT Shiverick","year":"1999","journal-title":"Placenta"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/sj.ijo.802200","article-title":"Early determinants of childhood overweight and adiposity in a birth cohort study: role of breast-feeding.","volume":"27","author":"KE Bergmann","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/bmj.324.7328.26","article-title":"Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort.","volume":"324","author":"SM Montgomery","year":"2002","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/intjepid\/31.2.413","article-title":"Fetal environment and subsequent obesity: a study of maternal smoking.","volume":"31","author":"C Power","year":"2002","journal-title":"Int J Epidemiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00431-002-0983-z","article-title":"Childhood obesity is associated with maternal smoking in pregnancy.","volume":"161","author":"AM Toschke","year":"2002","journal-title":"Eur J Pediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0378-3782(96)01735-5","article-title":"Pre- and post-natal growth in children of women who smoked in pregnancy.","volume":"45","author":"T Vik","year":"1996","journal-title":"Early Hum Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/aje\/kwf128","article-title":"Maternal smoking during pregnancy and childhood obesity.","volume":"156","author":"KR Von","year":"2002","journal-title":"Am J Epidemiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-3016.2003.00481.x","article-title":"Does maternal smoking during pregnancy cause childhood overweight?","volume":"17","author":"M Wideroe","year":"2003","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1677\/JOE-07-0050","article-title":"Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure.","volume":"194","author":"JE Bruin","year":"2007","journal-title":"J Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1007\/s00125-005-0022-5","article-title":"Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes.","volume":"48","author":"AC Holloway","year":"2005","journal-title":"Diabetologia"},{"key":"ref16","year":"1999"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.","volume":"52","author":"AE Butler","year":"2003","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.numecd.2005.10.017","article-title":"The pancreatic beta-cell in human Type 2 diabetes.","volume":"16","author":"P Marchetti","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.","volume":"39","author":"DC Wallace","year":"2005","journal-title":"Annu Rev Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death.","volume":"305","author":"DR Green","year":"2004","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.freeradbiomed.2008.02.010","article-title":"Maternal nicotine exposure increases oxidative stress in the offspring.","volume":"44","author":"JE Bruin","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/toxsci\/kfn012","article-title":"Increased pancreatic beta cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria.","volume":"103","author":"JE Bruin","year":"2008","journal-title":"Toxicol Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1042\/BST0340824","article-title":"Mitochondrial damages and the regulation of insulin secretion.","volume":"34","author":"P Maechler","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","article-title":"Mitochondrial dysfunction and type 2 diabetes.","volume":"307","author":"BB Lowell","year":"2005","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1098\/rstb.2005.1762","article-title":"Glucose-sensing mechanisms in pancreatic beta-cells.","volume":"360","author":"PE MacDonald","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00125-004-1627-9","article-title":"Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.","volume":"48","author":"M Anello","year":"2005","journal-title":"Diabetologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"28785","DOI":"10.1074\/jbc.M505695200","article-title":"Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure.","volume":"280","author":"RA Simmons","year":"2005","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1385\/ENDO:30:2:213","article-title":"Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats.","volume":"30","author":"AC Holloway","year":"2006","journal-title":"Endocrine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ncb1630","article-title":"Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis.","volume":"9","author":"MG Sun","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.freeradbiomed.2005.03.024","article-title":"Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults.","volume":"39","author":"G Parise","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biocel.2005.12.006","article-title":"In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.","volume":"38","author":"P Maechler","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.freeradbiomed.2005.12.018","article-title":"Developmental origins of diabetes: the role of oxidative stress.","volume":"40","author":"RA Simmons","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0891-5849(94)00221-5","article-title":"Free radical production in nicotine treated pancreatic tissue.","volume":"18","author":"GJ Wetscher","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000086130","article-title":"Effects of maternal nicotine exposure during lactation on breast-fed rat pups.","volume":"88","author":"BH Ozokutan","year":"2005","journal-title":"Biol Neonate"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0741-8329(01)00176-8","article-title":"Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system.","volume":"25","author":"K Husain","year":"2001","journal-title":"Alcohol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.2337\/diabetes.54.9.2602","article-title":"Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells.","volume":"54","author":"WH Kim","year":"2005","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.2337\/db07-0279","article-title":"Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.","volume":"56","author":"C Tang","year":"2007","journal-title":"Diabetes"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0891-5849(96)02051-5","article-title":"Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.","volume":"20","author":"S Lenzen","year":"1996","journal-title":"Free Radic Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2337\/diab.46.11.1733","article-title":"Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.","volume":"46","author":"M Tiedge","year":"1997","journal-title":"Diabetes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1210\/en.2002-220174","article-title":"Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure.","volume":"143","author":"G Leibowitz","year":"2002","journal-title":"Endocrinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00795-006-0324-9","article-title":"Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats.","volume":"39","author":"K Momose","year":"2006","journal-title":"Med Mol Morphol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0303-7207(97)00220-7","article-title":"Ultrastructural and secretory heterogeneity of fa\/fa (Zucker) rat islets.","volume":"136","author":"CB Chan","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/81649","article-title":"Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.","volume":"26","author":"JP Silva","year":"2000","journal-title":"Nat Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0005-2728(02)00263-3","article-title":"Manipulation of mitochondrial DNA gene expression in the mouse.","volume":"1555","author":"JP Silva","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1359105307074240","article-title":"Critical review: nicotine for the fetus, the infant and the adolescent?","volume":"12","author":"KH Ginzel","year":"2007","journal-title":"J Health Psychol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0003371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T08:23:05Z","timestamp":1540369385000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0003371"}},"subtitle":[],"editor":[{"given":"Adrian","family":"Vella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,8]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0003371","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,8]]}}}