{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:00Z","timestamp":1791031140050,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T00:00:00Z","timestamp":1224460800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0003448","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T17:45:57Z","timestamp":1224265557000},"page":"e3448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells"],"prefix":"10.1371","volume":"3","author":[{"given":"C\u00e9sar","family":"Mattei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong D.","family":"Nguyen-Huu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Bourdelais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Baden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Molg\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric A.","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0041-0101(00)00161-6","article-title":"The changing face of ciguatera.","volume":"39","author":"RJ Lewis","year":"2001","journal-title":"Toxicon"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1474-4422(05)70041-7","article-title":"Neurotoxic marine poisoning.","volume":"4","author":"GK Isbister","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/jnnp.2007.129049","article-title":"Ciguatera poisoning.","volume":"7","author":"KC Achaibar","year":"2007","journal-title":"Pract Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.toxicon.2006.07.032","article-title":"Species selective resistance of cardiac muscle voltage gated sodium channels: characterization of brevetoxin and ciguatoxin binding sites in rats and fish.","volume":"48","author":"MY Dechraoui","year":"2006","journal-title":"Toxicon"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0014-5793(87)80252-1","article-title":"Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na<sup>+<\/sup> channel.","volume":"219","author":"A Lombet","year":"1987","journal-title":"FEBS Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0026-895X(25)10324-6","article-title":"Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes.","volume":"30","author":"MA Poli","year":"1986","journal-title":"Mol Pharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1051\/jbio\/1999193030329","article-title":"Ciguatoxins and brevetoxins: dissection of the neurobiological actions.","volume":"193","author":"C Mattei","year":"1999","journal-title":"J Soc Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0306-4522(95)00506-4","article-title":"Nodal swelling produced by ciguatoxin-induced selective activation of sodium channels in myelinated nerve fibers.","volume":"71","author":"E Benoit","year":"1996","journal-title":"Neuroscience"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1476-5381.1990.tb12991.x","article-title":"Ciguatoxin enhances quantal transmitter release from frog motor nerve terminals.","volume":"99","author":"J Molg\u00f3","year":"1990","journal-title":"Br J Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/jnnp.70.1.4","article-title":"Neurology of ciguatera.","volume":"70","author":"J Pearn","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/sj.bjp.0704980","article-title":"Pacific ciguatoxin-1b effect over Na<sup>+<\/sup> and K<sup>+<\/sup> currents, inositol 1,4,5-triphosphate content and intracellular Ca<sup>2+<\/sup> signals in cultured rat myotubes.","volume":"137","author":"J Hidalgo","year":"2002","journal-title":"Br J Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(93)90250-O","article-title":"Ciguatoxin, extracted from poisonous morays eels, causes sodium-dependent calcium mobilization in NG108-15 neuroblastoma\u00d7glioma hybrid cells.","volume":"158","author":"J Molg\u00f3","year":"1993","journal-title":"Neurosci Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(93)9000-4","article-title":"Ciguatoxin extracted from poisonous moray eels <italic>Gymnothorax javanicus<\/italic> triggers acetylcholine release from Torpedo cholinergic synaptosomes via reversed Na<sup>+<\/sup>-Ca<sup>2+<\/sup> exchange.","volume":"160","author":"J Molg\u00f3","year":"1993","journal-title":"Neurosci Lett"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1242\/jcs.113.7.1119","article-title":"Trachynilysin mediates SNARE-dependent release of catecholamines from chromaffin cells via external and stored Ca<sup>2+<\/sup>.","volume":"113","author":"FA Meunier","year":"2000","journal-title":"J Cell Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1432-1033.1994.tb18871.x","article-title":"Botulinum A and the light chain of tetanus toxins inhibit distinct stages of Mg.ATP-dependent catecholamine exocytosis from permeabilised chromaffin cells.","volume":"222","author":"GW Lawrence","year":"1994","journal-title":"Eur J Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ceca.2005.06.012","article-title":"Calcium-dependent regulation of exocytosis.","volume":"38","author":"JW Barclay","year":"2005","journal-title":"Cell Calcium"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/375645a0","article-title":"The synaptic vesicle cycle: a cascade of protein-protein interactions.","volume":"375","author":"TC Sudhof","year":"1995","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0304-4157(91)90024-Q","article-title":"Control of exocytosis in adrenal chromaffin cells.","volume":"1071","author":"RD Burgoyne","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-5793(90)81514-O","article-title":"The caffeine-sensitive Ca<sup>2+<\/sup> store in bovine adrenal chromaffin cells; an examination of its role in triggering secretion and Ca<sup>2+<\/sup> homeostasis.","volume":"266","author":"TR Cheek","year":"1990","journal-title":"FEBS Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxicon.2006.09.022","article-title":"Voltage-gated ion channels and gating modifier toxins.","volume":"49","author":"WA Catterall","year":"2007","journal-title":"Toxicon"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.","volume":"82","author":"S Cestele","year":"2000","journal-title":"Biochimie"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1023\/B:CEMN.0000023629.81595.09","article-title":"Brevenal Is a Natural Inhibitor of Brevetoxin Action in Sodium Channel Receptor Binding Assays.","volume":"24","author":"AJ Bourdelais","year":"2004","journal-title":"Cellular and Molecular Neurobiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1016\/S0021-9258(17)39735-1","article-title":"Ciguatoxin is a novel type of Na<sup>+<\/sup> channel toxin.","volume":"259","author":"JN Bidard","year":"1984","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-3565(24)37963-7","article-title":"Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons.","volume":"288","author":"LC Strachan","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3940(97)00665-4","article-title":"Gambiertoxin (CTX-4B), purified from wild <italic>Gambierdiscus toxicus<\/italic> dinoflagellates, induces Na<sup>+<\/sup>-dependent swelling of single frog myelinated axons and motor nerve terminals in situ.","volume":"234","author":"C Mattei","year":"1997","journal-title":"Neurosci Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-8993(99)02032-6","article-title":"Hyperosmolar D-mannitol reverses the increased membrane excitability and the nodal swelling caused by Caribbean ciguatoxin-1 in single frog myelinated axons.","volume":"847","author":"C Mattei","year":"1999","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0306-4522(96)00568-4","article-title":"Sodium-dependent increase in quantal secretion induced by brevetoxin-3 in Ca<sup>2+<\/sup>-free medium is associated with depletion of synaptic vesicles and swelling of motor nerve terminals in situ.","volume":"78","author":"FA Meunier","year":"1997","journal-title":"Neuroscience"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(98)00575-8","article-title":"Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones.","volume":"252","author":"RC Hogg","year":"1998","journal-title":"Neurosci Lett"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0022-3565(25)10476-X","article-title":"Cooperative modulation of voltage-dependent sodium channels by brevetoxin and classical neurotoxins in cultured bovine adrenal medullary cells.","volume":"263","author":"A Wada","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1073\/pnas.121085898","article-title":"Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels.","volume":"98","author":"WI Li","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1113\/jphysiol.1995.sp020496","article-title":"Veratridine-induced oscillations of cytosolic calcium and membrane potential in bovine chromaffin cells.","volume":"482","author":"MG Lopez","year":"1995","journal-title":"J Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1254\/jphs.FPJ06006X","article-title":"Inhibition by SEA0400, a selective inhibitor of Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger, of Na<sup>+<\/sup>-dependent Ca<sup>2+<\/sup> uptake and catecholamine release in bovine adrenal chromaffin cells.","volume":"102","author":"S Soma","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/j.1460-2075.1989.tb03391.x","article-title":"Localization and heterogeneity of agonist-induced changes in cytosolic calcium concentration in single bovine adrenal chromaffin cells from video imaging of fura-2.","volume":"8","author":"AJ O'Sullivan","year":"1989","journal-title":"Embo J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"E263","DOI":"10.1038\/ncb1102-e263","article-title":"The cellular and molecular basis of store-operated calcium entry.","volume":"4","author":"K Venkatachalam","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"27076","DOI":"10.1016\/S0021-9258(19)74220-3","article-title":"Quantal Ca<sup>2+<\/sup> release from caffeine-sensitive stores in adrenal chromaffin cells.","volume":"268","author":"TR Cheek","year":"1993","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1054\/ceca.2000.0160","article-title":"Neurotransmitter release from bovine adrenal chromaffin cells is modulated by capacitative Ca<sup>2+<\/sup> entry driven by depleted internal Ca<sup>2+<\/sup> stores.","volume":"29","author":"M Zerbes","year":"2001","journal-title":"Cell Calcium"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1023\/B:CEMN.0000023629.81595.09","article-title":"Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays.","volume":"24","author":"AJ Bourdelais","year":"2004","journal-title":"Cell Mol Neurobiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/jpet.107.124271","article-title":"Gambierol Acts as a Functional Antagonist of Neurotoxin Site 5 on Voltage-Gated Sodium Channels in Cerebellar Granule Neurons.","volume":"323","author":"KT LePage","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/1074-5521(95)90187-6","article-title":"The relationship of brevetoxin \u2018length\u2019 and A-ring functionality to binding and activity in neuronal sodium channels.","volume":"2","author":"RE Gawley","year":"1995","journal-title":"Chem Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/np049797o","article-title":"A New Polyether Ladder Compound Produced by the Dinoflagellate Karenia.","volume":"68","author":"AJ Bourdelais","year":"2005","journal-title":"J Nat Prod"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1164\/rccm.200406-735OC","article-title":"Airway responses to aerosolized brevetoxins in an animal model of asthma.","volume":"171","author":"WM Abraham","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF00172577","article-title":"Distinct targets for tetanus and botulinum A neurotoxins within the signal transducing pathway in chromaffin cells.","volume":"344","author":"P Marxen","year":"1991","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00003882","article-title":"Isolation and some properties of ciguatoxin.","volume":"1","author":"AM Legrand","year":"1989","journal-title":"J Appl Phycol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1021\/ja00167a040","article-title":"Structures and configurations of ciguatoxin from the Moray eel <italic>Gymnothorax javanicus<\/italic> and its likely precursor from the dinoflagellate.","volume":"112","author":"M Murata","year":"1990","journal-title":"J Am Chem Soc"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/cbic.200700317","article-title":"Synthesis, modeling, and biological evaluation of analogues of the semisynthetic brevetoxin antagonist beta-naphthoyl-brevetoxin.","volume":"8","author":"S Michelliza","year":"2007","journal-title":"Chembiochem"},{"key":"ref46","first-page":"143","article-title":"Growth of clostridia and preparation of their neurotoxins.","volume":"195","author":"CC Shone","year":"1995","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0003448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T03:12:52Z","timestamp":1738465972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0003448"}},"subtitle":[],"editor":[{"given":"Mark R.","family":"Cookson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,20]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0003448","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,20]]}}}