{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:21:15Z","timestamp":1790104875209,"version":"4.0.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T00:00:00Z","timestamp":1231200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004130","type":"journal-article","created":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T00:30:18Z","timestamp":1231201818000},"page":"e4130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Temporal Dynamics of Interferon Gamma Responses in Children Evaluated for Tuberculosis"],"prefix":"10.1371","volume":"4","author":[{"given":"Jean-Louis","family":"Herrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Belloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Porcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Simonney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Aboutaam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Lebourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gaudelus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"De LosAngeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Chadelat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Scheinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Beydon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Fauroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Bingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Terki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Barraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cruaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Offredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Ferroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Berche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Moissenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Vuthien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Doit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Bingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Henri","family":"Lagrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,1,6]]},"reference":[{"key":"ref1","article-title":"Global tuberculosis control: surveillance, planning, financing."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S1473-3099(03)00771-0","article-title":"Diagnosis and treatment of tuberculosis in children.","volume":"3","author":"D Shingadia","year":"2003","journal-title":"The Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/adc.2006.104976","article-title":"Recent advances in the diagnosis of childhood tuberculosis.","volume":"92","author":"BJ Marais","year":"2007","journal-title":"Arch Dis Child"},{"key":"ref4","article-title":"Guidance for national tuberculosis programmes on the management of tuberculosis in children."},{"key":"ref5","first-page":"6","article-title":"Tuberculosis in developing countries: burden, intervention and cost.","volume":"65","author":"CJ Murray","year":"1990","journal-title":"Bull Int Union Tuberc Lung Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/adc.80.5.433","article-title":"Childhood tuberculosis in an urban population in South Africa: burden and risk factor.","volume":"80","author":"A van Rie","year":"1999","journal-title":"Arch Dis Child"},{"key":"ref7","first-page":"152","article-title":"Analysis of circulating immune complexes (CICs) in childhood tuberculosis: levels of specific antibodies to glycolipid antigens and relationship with serum antibodies.","volume":"4","author":"N Simonney","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1002\/ppul.1950322326","article-title":"Usefulness of serological tests in childhood TB.","volume":"23","author":"PH Lagrange","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"ref9","first-page":"69","article-title":"Cases of tuberculosis diseases notified in France in 2006.","volume":"10\u201311","author":"D Antoine","year":"2008","journal-title":"Bull Epid Hebdomadaire"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S1473-3099(04)01206-X","article-title":"Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review.","volume":"4","author":"M Pai","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0140-6736(03)12950-9","article-title":"Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak.","volume":"361","author":"K Ewer","year":"2003","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S0140-6736(04)17592-2","article-title":"Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study.","volume":"364","author":"S Lieberschuetz","year":"2004","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1086\/429245","article-title":"Enzyme-linked immunospot assay responses to early secretary antigenic target, culture filtrate protein 10, and purified protein derivative among children with tuberculosis: implications for diagnosis and monitoring of therapy.","volume":"40","author":"MP Nicol","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/thx.2005.048033","article-title":"Performance of a whole blood interferon gamma assay for detecting latent infection with <italic>Mycobacterium tuberculosis<\/italic> in children.","volume":"61","author":"TG Connell","year":"2006","journal-title":"Thorax"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e2624","DOI":"10.1371\/journal.pone.0002624","article-title":"A three-way comparison of tuberculin skin testing, QuantiFERON-TB Gold and T-SPOT.TB in children.","volume":"3(7)","author":"TG Connell","year":"2008","journal-title":"PLOS One"},{"key":"ref16","first-page":"939","article-title":"Results of a tuberculosis-specific IFN-\u03b3 assay in children at high risk for tuberculosis infection.","volume":"10","author":"SJ Tsiouris","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3201\/eid1209.051606","article-title":"Risk for tuberculosis among children.","volume":"12","author":"H Nakaoka","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1086\/519266","article-title":"Comparison of QFT Gold In-Tube and T-Spot in Children: Interferon-gamma release assays improve the diagnosis of tuberculosis and non tuberculous mycobacterial disease in children in a country with a low incidence of tuberculosis.","volume":"45","author":"AK Detjen","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref19","first-page":"1","article-title":"Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children.","volume":"8","author":"K Okada","year":"2007","journal-title":"Epidemiol Infect"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jinf.2006.04.007","article-title":"Comparison of a whole blood interferon-\u03b3 assay with tuberculin skin testing for the detection of tuberculosis infection in hospitalized children in rural India.","volume":"54","author":"S Dogra","year":"2007","journal-title":"J Infect"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1440-1843.2006.01000.x","article-title":"Use of QuantiFeron\u00ae -TB Gold to investigate tuberculosis contacts in high school.","volume":"12","author":"K Higuchi","year":"2007","journal-title":"Respirology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1542\/peds.2005-2095","article-title":"Comparison of enzyme-linked immunospot assay and tuberculin skin test in healthy children exposed to <italic>Mycobacterium tuberculosis<\/italic>.","volume":"117","author":"PC Hill","year":"2006","journal-title":"Pediatrics"},{"key":"ref23","article-title":"A comparison of T-SPOT.<italic>TB<\/italic> and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting. Pediatrics.","author":"MP Nicol","year":"2008","journal-title":"Accepted for publication"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/QCO.0b013e32813e3fd8","article-title":"T cell-based diagnosis of childhood tuberculosis infection.","volume":"20","author":"A Lalvani","year":"2007","journal-title":"Curr Op Infect Dis"},{"key":"ref25","article-title":"IFN gamma and antibody responses among French nurses during a tuberculosis contact tracing investigation.","author":"JL Herrmann","year":"2008","journal-title":"Pathol Biol (Paris) [Apr 3, Epub ahead of print]"},{"key":"ref26","first-page":"S13","article-title":"What examinations are necessary in an exposed, asymptomatic child with a positive tuberculin skin test and normal chest x-ray ?","volume":"21","author":"C Delacourt","year":"2004","journal-title":"[in French] Rev Mal Respir"},{"key":"ref27","article-title":"Conseil Superieur d&apos;Hygiene Publique de France. TB case investigation: practice recommendations [in French]. [Created 2006 Mar; accessed 2008 Mar 14]."},{"key":"ref28","first-page":"70","article-title":"La tuberculose \u00e0 Paris en 2003, situation actuelle et contribution du Service de lutte anti-tuberculose.","volume":"17\u201318","author":"F Antoun","year":"2005","journal-title":"Bull Epid Hebdomadaire"},{"key":"ref29","first-page":"85","article-title":"Cases of tuberculosis diseases notified in France in 2005.","volume":"11","author":"D Antoine","year":"2007","journal-title":"Bull Epid Hebdomadaire"},{"key":"ref30","first-page":"90","article-title":"Contacts of cases of active pulmonary tuberculosis.","volume":"50","author":"S Grzybowski","year":"1975","journal-title":"Bull Int Union Tuberc"},{"key":"ref31","first-page":"895","article-title":"Tuberculin reactivity and the risk of tuberculosis: a review.","volume":"4","author":"RE Watkins","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/rccm.200802-251ED","article-title":"Predicting tuberculosis: does IGRA tell the tall?","volume":"177","author":"JE Stout","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1164\/rccm.200711-1613OC","article-title":"Predictive value of a whole blood IFN-gamma assay for the development of active tuberculosis disease after recent infection with <italic>Mycobacterium tuberculosis<\/italic>.","volume":"177","author":"R Diel","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1164\/rccm.200711-1756OC","article-title":"Evaluation of a model for efficient screening of tuberculosis contact subjects.","volume":"177","author":"K Aissa","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molmed.2007.03.004","article-title":"The prognosis of latent tuberculosis: can disease be predicted?","volume":"13","author":"P Andersen","year":"2007","journal-title":"Trends Mol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/JCM.40.2.704-706.2002","article-title":"Immune responses to the <italic>Mycobacterium tuberculosis<\/italic>-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients.","volume":"40","author":"TM Doherty","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.4049\/jimmunol.167.9.5217","article-title":"Direct <italic>ex vivo<\/italic> analysis of antigen-specific IFN-gamma-secreting CD4 T-cells in <italic>Mycobacterium tuberculosis<\/italic>-infected individuals: associations with clinical disease state and effect of treatment.","volume":"167","author":"AA Pathan","year":"2001","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/IAI.70.6.3026-3032.2002","article-title":"Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following <italic>Mycobacterium bovis<\/italic> BCG vaccination against experimental bovine tuberculosis.","volume":"70","author":"HM Vordermeier","year":"2002","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetimm.2005.08.002","article-title":"Identification of immune response correlates for protection against bovine tuberculosis.","volume":"108","author":"BM Buddle","year":"2005","journal-title":"Vet Immunol Immunopathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1016\/j.vaccine.2004.11.051","article-title":"Protection of macaques against <italic>Mycobacterium tuberculosis<\/italic> infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.","volume":"23","author":"JA Langermans","year":"2005","journal-title":"Vaccine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1128\/IAI.69.10.6554-6557.2001","article-title":"Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.","volume":"69","author":"J Vekemans","year":"2001","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1164\/rccm.200511-1783OC","article-title":"Dynamic antigen-specific T-cell responses after point-source exposure to <italic>Mycobacterium tuberculosis<\/italic>.","volume":"174","author":"K Ewer","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1086\/499311","article-title":"Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens.","volume":"193","author":"KA Wilkinson","year":"2006","journal-title":"J Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1850","DOI":"10.1371\/journal.pone.0001850","article-title":"T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data.","volume":"3(3)","author":"A Veerapathran","year":"2008","journal-title":"PLoS ONE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1183\/09031936.00117506","article-title":"Effect of tuberculin skin testing on <italic>Mycobacterium tuberculosis<\/italic>-specific interferon-gamma assay.","volume":"29","author":"EM Leyten","year":"2007","journal-title":"Eur Resp J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1086\/515336","article-title":"Peptide-specific T cell response to <italic>Mycobacterium tuberculosis<\/italic>: clinical spectrum, compartmentalization, and effect of chemotherapy.","volume":"178","author":"RJ Wilkinson","year":"1998","journal-title":"J Infect Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1097\/01.aids.0000202648.18526.bf","article-title":"Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients.","volume":"20(2)","author":"A Bourgarit","year":"2006","journal-title":"AIDS"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nm859","article-title":"Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.","volume":"9","author":"AS Pym","year":"2003","journal-title":"Nat Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1086\/381763","article-title":"Counting antigen-specific T cells: a new approach for monitoring response to tuberculosis treatment?","volume":"38","author":"A Lalvani","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1086\/381754","article-title":"Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy.","volume":"38","author":"S Carrara","year":"2004","journal-title":"Clin Infect Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:42:17Z","timestamp":1589031737000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004130"}},"subtitle":[],"editor":[{"given":"Ben","family":"Marais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,1,6]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004130","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,6]]}}}