{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:42:24Z","timestamp":1789724544907,"version":"4.0.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2009,1,12]],"date-time":"2009-01-12T00:00:00Z","timestamp":1231718400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004176","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T18:54:31Z","timestamp":1231527271000},"page":"e4176","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["Augmented Lung Inflammation Protects against Influenza A Pneumonia"],"prefix":"10.1371","volume":"4","author":[{"given":"Michael J.","family":"Tuvim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia G.","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton F.","family":"Dickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,1,12]]},"reference":[{"key":"ref1","article-title":"The World Health Report 2004 \u2013 Changing History","year":"2004"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0140-6736(03)15021-0","article-title":"Community-acquired pneumonia.","volume":"362","author":"TM File","year":"2003","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1513\/pats.200508-097JS","article-title":"Breakdown of pulmonary host defense in the immunocompromised host: cancer chemotherapy.","volume":"2","author":"L Joos","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/aje\/kwj024","article-title":"Mortality due to influenza in the United States\u2013an annualized regression approach using multiple-cause mortality data.","volume":"163","author":"J Dushoff","year":"2006","journal-title":"Am J Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.amjmed.2007.10.040","article-title":"Complications of viral influenza.","volume":"121","author":"MB Rothberg","year":"2008","journal-title":"Am J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1353\/bhm.2002.0022","article-title":"Updating the accounts: global mortality of the 1918\u20131920 \u201cSpanish\u201d influenza pandemic.","volume":"76","author":"NP Johnson","year":"2002","journal-title":"Bull Hist Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e2268","DOI":"10.1371\/journal.pone.0002268","article-title":"Environmental factors contributing to the spread of H5N1 avian influenza in mainland China.","volume":"3","author":"LQ Fang","year":"2008","journal-title":"PLoS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1016\/S0264-410X(02)00300-6","article-title":"Overview: cause and prevention in biowarfare and bioterrorism.","volume":"20","author":"MR Hilleman","year":"2002","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra0707279","article-title":"Update on avian influenza A (H5N1) virus infection in humans.","volume":"358","author":"AN Abdel-Ghafar","year":"2008","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature05181","article-title":"Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.","volume":"443","author":"JC Kash","year":"2006","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature05495","article-title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.","volume":"445","author":"D Kobasa","year":"2007","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.","volume":"133","author":"Y Imai","year":"2008","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chom.2007.09.001","article-title":"Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.","volume":"2","author":"JL McAuley","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1473-3099(06)70466-2","article-title":"Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness.","volume":"6","author":"JF Brundage","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm1765","article-title":"Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection.","volume":"14","author":"K Sun","year":"2008","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1164\/rccm.200607-1038OC","article-title":"Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice.","volume":"177","author":"CG Clement","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3201\/eid1201.051186","article-title":"Antiviral response in pandemic influenza viruses.","volume":"12","author":"A Garcia-Sastre","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1462-5822.2007.00961.x","article-title":"Innate immunity to respiratory viruses.","volume":"9","author":"JP Wang","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.antiviral.2008.01.005","article-title":"MegaRibavirin aerosol for the treatment of influenza A virus infections in mice.","volume":"78","author":"BE Gilbert","year":"2008","journal-title":"Antiviral Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1073\/pnas.0705289104","article-title":"Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection.","volume":"104","author":"R Salomon","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1128\/AAC.00219-07","article-title":"Increased survival after gemfibrozil treatment of severe mouse influenza.","volume":"51","author":"A Budd","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1073\/pnas.0711942105","article-title":"Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A\/H5N1 virus.","volume":"105","author":"BJ Zheng","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/CMR.00023-07","article-title":"Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection.","volume":"20","author":"VC Cheng","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nature06956","article-title":"Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.","volume":"453","author":"PJ Collins","year":"2008","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1086\/507552","article-title":"Antiviral management of seasonal and pandemic influenza.","volume":"194","author":"FG Hayden","year":"2006","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1165\/rcmb.2007-0366OC","article-title":"Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype.","volume":"38","author":"SJ Moghaddam","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications.","volume":"447","author":"SL Foster","year":"2007","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm1633","article-title":"Adaptive immune cells temper initial innate responses.","volume":"13","author":"KD Kim","year":"2007","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/IAI.15.1.221-229.1977","article-title":"Effects of low- and high-passage influenza virus infection in normal and nude mice.","volume":"15","author":"PR Wyde","year":"1977","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0166-3542(92)90088-M","article-title":"Further studies with short duration ribavirin aerosol for the treatment of influenza virus infection in mice and respiratory syncytial virus infection in cotton rats.","volume":"17","author":"BE Gilbert","year":"1992","journal-title":"Antiviral Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T10:40:24Z","timestamp":1589452824000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004176"}},"subtitle":[],"editor":[{"given":"Ludovic","family":"Tailleux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,1,12]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004176","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1158120.618225","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,12]]}}}