{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:22:24Z","timestamp":1791044544738,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004420","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:03Z","timestamp":1234224003000},"page":"e4420","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Human T Cell Leukemia Virus Reactivation with Progression of Adult T-Cell Leukemia-Lymphoma"],"prefix":"10.1371","volume":"4","clinical-trial-number":[{"clinical-trial-number":"nct00041327","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lee","family":"Ratner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela","family":"Noy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sparano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ambinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lairmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"for the AIDS Malignancy Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.","volume":"7","author":"M Matsuoka","year":"2007","journal-title":"Nature Reviews in Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I and associated diseases.","volume":"24","author":"FA Proietti","year":"2005","journal-title":"Oncogene"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1038\/sj.onc.1208969","article-title":"Activation of NF-B by HTLV-I and implications for cell transformation.","volume":"24","author":"S-C Sun","year":"2005","journal-title":"Oncogene"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1038\/sj.onc.1208979","article-title":"Natural history of adult T-cell leukemia\/lymphoma and approaches to therapy.","volume":"24","author":"GP Taylor","year":"2005","journal-title":"Oncogene"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.2741\/1442","article-title":"Adult T cell leukemia lymphoma.","volume":"9","author":"L Ratner","year":"2004","journal-title":"Frontiers in Biosciences"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma: a report from the Lymphoma Study Group.","volume":"79","author":"M Shimoyama","year":"1991","journal-title":"British Journal of Hematology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0145-2126(92)90168-7","article-title":"Phenotypic diversity and prognosis of adult T-cell leukemia.","volume":"16","author":"S Kamihira","year":"1992","journal-title":"Leukemia Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/ijc.22536","article-title":"Regulatory T-cell function of adult T-cell leukemia\/lymphoma cells.","volume":"120","author":"H Yano","year":"2007","journal-title":"International Journal of Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1600-0609.2008.01105.x","article-title":"Foxp3 expression on normal and leukemic CD4(+)CD25(+) T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells.","volume":"81","author":"M Abe","year":"2008","journal-title":"European Journal of Hematology"},{"key":"ref10","first-page":"98","article-title":"Adult T-cell leukemia\/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells.","volume":"99","author":"T Shimauchi","year":"2008","journal-title":"Cancer Science 2008;"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1182\/blood-2006-11-051672","article-title":"Proposed classification of lymphoid neoplasms for epidemiologic research from the International Lymphoma Epidemiology Consortium (InterLymph).","volume":"110","author":"LM Morton","year":"2007","journal-title":"Blood"},{"key":"ref12","article-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.","author":"ES Jaffe","year":"2001"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S1470-2045(04)01608-0","article-title":"New therapeutic approaches for adult T-cell leukaemia.","volume":"5","author":"A Bazarbachi","year":"2004","journal-title":"Lancet Oncology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1182\/blood-2002-11-3589","article-title":"Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology.","volume":"101","author":"RF Little","year":"2003","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1182\/blood.V99.8.2685","article-title":"Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy.","volume":"99","author":"WH Wilson","year":"2002","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1056\/NEJM199506293322603","article-title":"Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine.","volume":"332","author":"PS Gill","year":"1995","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJM199506293322604","article-title":"Treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa.","volume":"332","author":"O Hermine","year":"1995","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10289","DOI":"10.1128\/JVI.73.12.10289-10295.1999","article-title":"Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T cell phenotype, and anti-Tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy.","volume":"73","author":"GP Taylor","year":"1999","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1200\/JCO.1999.17.4.1244","article-title":"Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group.","volume":"17","author":"BD Cheson","year":"1999","journal-title":"Journal of Clinical Oncology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(89)90015-9","article-title":"Optimal two-stage designs for phase II clinical trials.","volume":"10","author":"R Simon","year":"1989","journal-title":"Control Clinical Trials"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/317932","article-title":"Incrased activated human T celll ymphotropic virus type I (HTLV-I) Tax 11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associatd myelopathy\/tropical spastic paraparesis: Correlation with HTLV-I proviral load.","volume":"183","author":"M Nagai","year":"2001","journal-title":"Journal of Infectious Diseases"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1182\/blood.V99.1.88","article-title":"Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1-associated myelopathy (HAM\/TSP).","volume":"99","author":"Y Yamano","year":"2002","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1182\/blood-2006-08-038257","article-title":"The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.","volume":"109","author":"LH Sehn","year":"2007","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2141.2001.02737.x","article-title":"A new G-CSF supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303.","volume":"113","author":"Y Yamada","year":"2001","journal-title":"British Journal of Hematology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.leu.2402777","article-title":"Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo.","volume":"17","author":"F Mortreux","year":"2003","journal-title":"Leukemia"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1182\/blood.V97.4.987","article-title":"Existence of escape mutant in HTLV-1 tax during the development of adult T-cell leukemia.","volume":"97","author":"Y Furukawa","year":"2001","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood.V85.7.1865.bloodjournal8571865","article-title":"T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells.","volume":"85","author":"R Furukawa","year":"1995","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1128\/JVI.76.18.9389-9397.2002","article-title":"5\u2032-Long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo.","volume":"76","author":"T Koiwa","year":"2002","journal-title":"Journal of Virology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/135965350100603S03","article-title":"Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure.","volume":"6","author":"V Miller","year":"2001","journal-title":"Antiviral Therapy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ijc.21328","article-title":"HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia.","volume":"118","author":"Y Furukawa","year":"2006","journal-title":"International Journal of Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1086\/339002","article-title":"Genetic evidence of transmission of human T cell lymphotropic virus tyep 1 between spouses.","volume":"185","author":"M Iga","year":"2002","journal-title":"Journal of Infectious Diseases"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1099\/0022-1317-74-11-2531","article-title":"Complete sequence conservation of the human T cell leukaemia virus type 1 tax gene within a family cluster showing differnet pathologies.","volume":"74","author":"ME Major","year":"1993","journal-title":"Journal of General Virology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2005.05.015","article-title":"Activation of human T cell leukemia virus type 1 LTR promoter and cellular promoter elements by T cell receptor signaling and HTLV-1 Tax expression.","volume":"339","author":"HC Lin","year":"2005","journal-title":"Virology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1080\/10428190500244217","article-title":"Inactivation of tumor suppressor genes and the progression of adult T-cell leukemia-lymphoma.","volume":"46","author":"Y Yamada","year":"2005","journal-title":"Leukemia Lymphoma"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2174\/138945006778559247","article-title":"Proteasome inhibition as a new therapeutic principle in hematological malignancies.","volume":"7","author":"CS Mitsiades","year":"2006","journal-title":"Current Drug Targets"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1358\/dnp.2006.19.4.985934","article-title":"Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia\/lymphoma.","volume":"19","author":"R Horie","year":"2006","journal-title":"Drug News Perspectives"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molmed.2006.11.002","article-title":"MDM2 inhibitors for cancer therapy.","volume":"13","author":"LT Vassilev","year":"2007","journal-title":"Trends in Molecular Medicine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0065-2776(06)90003-0","article-title":"Development of antibodies and chimeric molecules for cancer immunotherapy.","volume":"90","author":"TA Waldmann","year":"2006","journal-title":"Advances in Immunology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbmt.2006.09.002","article-title":"Allogeneic bone marrow transplantation from unrelated human T-cell leukemia virus-I-negative donors for adult T-cell leukemia\/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program.","volume":"13","author":"K Kato","year":"2007","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T23:08:23Z","timestamp":1684883303000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004420"}},"subtitle":[],"editor":[{"given":"Esper Georges","family":"Kallas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,2,10]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004420","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,10]]}}}