{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:37:06Z","timestamp":1790861826388,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004453","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T11:17:27Z","timestamp":1234351047000},"page":"e4453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":78,"title":["Maternal Circulating Levels of Activin A, Inhibin A, sFlt-1 and Endoglin at Parturition in Normal Pregnancy and Pre-Eclampsia"],"prefix":"10.1371","volume":"4","author":[{"given":"Aparna","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Suri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian L.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W. G.","family":"Redman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanthi","family":"Muttukrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9440(10)63803-5","article-title":"Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies.","volume":"162(1)","author":"E Jauniaux","year":"2003","journal-title":"Am J Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension.","volume":"277(5332)","author":"O Genbacev","year":"1997","journal-title":"Science"},{"key":"ref3","article-title":"\u201cPlacental Vasculature and Circulation.\u201d","author":"EM Ramsey","year":"1980"},{"key":"ref4","first-page":"177","article-title":"\u201cThe role of the spiral arteries in the pathogenesis of preeclampsia.\u201d","volume":"1","author":"IA Brosens","year":"1972","journal-title":"Obstet Gynecol Annu"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S0962279900000776","article-title":"\u201cTrophoblast invasion.\u201d","volume":"3","author":"Pijnenborg","year":"1994","journal-title":"Reprod Med Rev"},{"key":"ref6","first-page":"939","article-title":"The uterine spiral arteries in human pregnancy: facts and controversies.","volume":"2006 Sep\u2013Oct;27(9\u201310)","author":"R Pijnenborg","journal-title":"Placenta"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1471-0528.2000.tb13271.x","article-title":"\u201cCorrelation between placental bed biopsy findings,vascular cell adhesion molocule and fibronectin levels in pre-eclampsia.\u201d","volume":"107(4)","author":"R Madazli","year":"2000","journal-title":"BJOG"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1210\/en.2004-1028","article-title":"Hypoxia and sFlt-1 in preeclampsia: the \u201cchicken- and-egg\u201d question.","volume":"Nov;145(11)","author":"SA Karumanchi","year":"2004","journal-title":"Endocrinology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia.","volume":"Jun 10;308(5728)","author":"CW Redman","year":"2005","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2265.1995.tb02648.x","article-title":"Measurement of serum concentrations of inhibin-A (alpha-beta A dimer) during human pregnancy.","volume":"Apr;42(4)","author":"S Muttukrishna","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref11","first-page":"3328","article-title":"Changes in peripheral serum levels of total activin A during the human menstrual cycle and pregnancy.","volume":"Sep;81(9)","author":"S Muttukrishna","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0140-6736(96)09264-1","article-title":"Activin A and inhibin A as possible endocrine markers for pre-eclampsia.","volume":"May 3;349(9061)","author":"S Muttukrishna","year":"1997","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1210\/jc.2002-021924","article-title":"Endothelial cells and peripheral blood mononuclear cells are a potential source of extraplacental activin a in preeclampsia.","volume":"Dec;88(12)","author":"DS Tannetta","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/15.7.1640","article-title":"Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia.","volume":"Jul;15(7)","author":"S Muttukrishna","year":"2000","journal-title":"Hum Reprod"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia.","volume":"350","author":"RJ Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.","volume":"355","author":"RJ Levine","year":"2006","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase-1 sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.","volume":"111","author":"SE Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1097\/01.AOG.0000264552.85436.a1","article-title":"Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia.","volume":"Jun;109(6)","author":"AK Wikstr\u00f6m","year":"2007","journal-title":"Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1210\/jc.2007-1550","article-title":"Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies.","volume":"Jan;93(1)","author":"Y Gu","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"175.e1","DOI":"10.1016\/j.ajog.2007.08.052","article-title":"Circulatory soluble endoglin and its predictive value for preeclampsia in second-trimester pregnancies with abnormal uterine perfusion.","volume":"Feb;198(2)","author":"H Stepan","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"174.e1","DOI":"10.1016\/j.ajog.2007.03.058","article-title":"Soluble endoglin as a second-trimester marker for preeclampsia.","volume":"Aug;197(2)","author":"CJ Robinson","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(99)00284-6","article-title":"Is oxidative stress the link in the two \u2013stage model of preeclampsia?","volume":"354","author":"JM Roberts","year":"1999","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/plac.2000.0560","article-title":"Placental debris, oxidative stress and preeclampsia.","volume":"21","author":"CWG Redman","year":"2000","journal-title":"Placenta"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/plac.2002.0870","article-title":"Effect of hypoxia on placental activin A, inhibin A and follistatin synthesis.","volume":"2003 Jan;24(1)","author":"U Manuelpillai","year":"2003","journal-title":"Placenta"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1.","volume":"May;71(10)","author":"A Makris","year":"2007","journal-title":"Kidney Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1677\/JOE-06-0061","article-title":"Oxidative stress increases placental and endothelial cell activin A secretion.","volume":"Mar;192(3)","author":"S Mandang","year":"2007","journal-title":"J Endocrinol"},{"key":"ref27","first-page":"278","article-title":"Activin at parturition: changes of maternal serum levels and evidence for binding sites in placenta and fetal membranes.","volume":"Aug;84(2)","author":"F Petraglia","year":"1994","journal-title":"Obstet Gynecol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1136\/bmj.309.6966.1395","article-title":"\u201cEclampsia in the United Kingdom.\u201d","volume":"309(6966)","author":"KA Douglas","year":"1994","journal-title":"BMJ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"\u201cMaternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome).","volume":"169(4)","author":"BM Sibai","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1071-5576(02)00165-X","article-title":"\u201cMechanism of increased maternal serum activin A and inhibin A in pre-eclampsia.\u201d","volume":"9","author":"HM Silver","year":"2002","journal-title":"J Soc Gynecol Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.placenta.2004.05.004","article-title":"Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta.","volume":"Feb\u2013Mar;26(2\u20133)","author":"H Li","year":"2005","journal-title":"Placenta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1471-0528.2000.tb10402.x","article-title":"Maternal serum total activin A and follistatin in pregnancy and parturition.","volume":"Aug;107(8)","author":"M Schneider-Kolsky","year":"2000","journal-title":"BJOG"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria.","volume":"278","author":"H Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1210\/jc.2002-021942","article-title":"Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia.","volume":"88","author":"K Koga","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref35","first-page":"1085","article-title":"Am J Physiol Regulatory Integrative Comp Physiol","volume":"291","author":"O Nevo","year":"2006","journal-title":"Am J Physiol Regulatory Integrative Comp Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajog.2004.11.038","article-title":"Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop pr eeclampsia.","volume":"Jul;193(1)","author":"RW Powers","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia.","volume":"12","author":"S Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.59.110106.214058","article-title":"Preeclampsia and angiogenic imbalance.","volume":"59","author":"S Maynard","year":"2008","journal-title":"Annu Rev Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0002-9378(88)90100-7","article-title":"Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry.","volume":"158","author":"HS Brar","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0002-9378(87)80342-3","article-title":"Uterine and umbilical artery velocimetry during normal labor.","volume":"157","author":"A Fleischer","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000067884","article-title":"Fetal blood saturation during the 1st and 2nd stage of labor and its relation to the neonatal outcome.","volume":"54(3)","author":"B Leszczy\u0144ska-Gorzelak","year":"2002","journal-title":"Gynecol Obstet Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00404-004-0722-y","article-title":"Alterations in Doppler velocimetry indices of the umbilical artery during fetal hypoxia in labor, in relation to cardiotocography and fetal pulse oximetry findings.","volume":"Sep;272(3)","author":"C Siristatidis","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s004040050255","article-title":"Reactive oxygen species in the process of labor.","volume":"263","author":"N Yaacobi","year":"1999","journal-title":"Arch Gynecol Obstet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0143-4004(97)90015-1","article-title":"Increased Xanthine oxidase in labor-implications of oxidative stress.","volume":"18","author":"A Many","year":"1997","journal-title":"Placenta"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1471-0528.2002.01494.x","article-title":"Active labour is associated with increased oxidisibility of serum lipids ex vivo.","volume":"Aug;109(8)","author":"O Fainaru","year":"2002","journal-title":"BJOG"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/eje.0.1450505","article-title":"Effect of cytokines and growth factors on the secretion of inhibin A, activin A and follistatin by term placental villous","volume":"Oct;145(4)","author":"A Mohan","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050500202493","article-title":"Evidence supporting that the excess of the sVEGFR-1 concentration in maternal in preeclampsia has a uterine origin.","volume":"Jul;18(1)","author":"E Bujold","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.placenta.2004.09.001","article-title":"Extra-placental expression of vascular endothelial growth factor receptor-1,(Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.","volume":"Aug;26(7)","author":"A Rajakumar","year":"2005","journal-title":"Placenta"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1210\/en.2004-0533","article-title":"Yamashita, et al. Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia.","volume":"Nov; 145(11)","author":"T Nagamatsu","year":"2004","journal-title":"Endocrinology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62567-9","article-title":"Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis elevated liver enzymes, and low platelets syndrome.","volume":"Apr;160(4)","author":"Y Zhou","year":"2002","journal-title":"Am J Pathol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/01.AOG.0000207698.74104.4f","article-title":"Fractional excretion of angiogenic factors in women with severe preeclampsia.","volume":"May;107(5)","author":"CS Buhimschi","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","article-title":"Oxidative stress, gene expression, and protein changes induced in the human placenta during labor.","volume":"Oct;171(4)","author":"T Cindrova-Davies","year":"2007","journal-title":"Am J Pathol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.ogx.0000219564.65999.0d","article-title":"Late postpartum eclampsia: examples and review.","volume":"Jul;61(7)","author":"J Hirshfeld-Cytron","year":"2006","journal-title":"Obstet Gynecol Surv"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ajog.2004.02.037","article-title":"Delayed postpartum preeclampsia: an experience of 151 cases.","volume":"May;190(5)","author":"LA Matthys","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.placenta.2008.08.018","article-title":"The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell free DNA and mRNA in normal pregnancy and pre-eclampsia.","volume":"2008 Nov;29(11)","author":"A Reddy","year":"2008","journal-title":"Placenta"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1161\/CIRCRESAHA.108.171504","article-title":"A novel human-specific soluble vascular endothelial growth factor receptor 1cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia.","volume":"Jun 20;102(12)","author":"S Sela","year":"2008","journal-title":"Circ Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:12:33Z","timestamp":1588986753000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004453"}},"subtitle":[],"editor":[{"given":"Cuilin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,2,11]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004453","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1160891.622318","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,11]]}}}