{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:26:28Z","timestamp":1791174388981,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2009,2,16]],"date-time":"2009-02-16T00:00:00Z","timestamp":1234742400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004488","type":"journal-article","created":{"date-parts":[[2009,2,14]],"date-time":"2009-02-14T12:07:17Z","timestamp":1234613237000},"page":"e4488","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":318,"title":["Relation of DNA Methylation of 5\u2032-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma"],"prefix":"10.1371","volume":"4","author":[{"given":"Frederica","family":"Perera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-yee","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Herbstman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuk-mei","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,2,16]]},"reference":[{"key":"ref1","first-page":"1","article-title":"in Prevention, CDC. Surveillance summaries in surveillance for asthma-United States, 1960\u20131995.","volume":"47","author":"M Mannino","year":"1998","journal-title":"MMWR"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1289\/ehp.8376","article-title":"Induction of asthma and the environment: what we know and need to know.","volume":"114","author":"MK Selgrade","year":"2006","journal-title":"Environ Health Perspect"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2105\/AJPH.2004.042705","article-title":"Addressing the childhood asthma crisis in Harlem: the Harlem Children&apos;s Zone Asthma Initiative.","volume":"95","author":"SW Nicholas","year":"2005","journal-title":"Am J Public Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.5742","article-title":"Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population.","volume":"111","author":"FP Perera","year":"2003","journal-title":"Environ Health Perspect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1378\/chest.126.4.1071","article-title":"Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort.","volume":"126","author":"RL Miller","year":"2004","journal-title":"Chest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jaci.2005.12.1348","article-title":"Endotoxin inner-city homes and the association with atopy and wheeze in the first two years of life.","volume":"117","author":"MS Perzanowski","year":"2006","journal-title":"J Allergy Clin Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11154-007-9051-3","article-title":"Environment and origin of disease.","volume":"8","author":"V Padmanabhan","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.reprotox.2006.10.001","article-title":"Developmental estrogen exposures predispose to prostate carcinogenesis with aging.","volume":"23","author":"GS Prins","year":"2007","journal-title":"Reprod Toxicol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tem.2006.09.002","article-title":"Fetal origins of breast cancer.","volume":"17","author":"L Hilakivi-Clarke","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11154-007-9042-4","article-title":"Epigenetic reprogramming and imprinting in origins of disease.","volume":"8","author":"WY Tang","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1164\/rccm.200710-1511PP","article-title":"Environmental Epigenetics and Asthma: Current Concepts and Call for Studies.","volume":"177","author":"RL Miller","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.2003.tb05971.x","article-title":"Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers.","volume":"983","author":"S Li","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility.","volume":"308","author":"MD Anway","year":"2005","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1158\/0008-5472.CAN-06-0516","article-title":"Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4.","volume":"66","author":"SM Ho","year":"2006","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1073\/pnas.0703739104","article-title":"Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.","volume":"104","author":"DC Dolinoy","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","article-title":"Persistent hypomethylation in the promoter of nucleosomal binding protein 1(Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein.","author":"WY Tang","year":"2008","journal-title":"Endocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1079\/BJN2001344","article-title":"Role of biomarkers in nutritional science and industry- a commentary.","volume":"86","author":"P Weber","year":"2001","journal-title":"Brit J of Nutrition"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0140-6736(00)02125-5","article-title":"White blood cells 1: non-malignant disorders.","volume":"355","author":"W Stock","year":"2000","journal-title":"Lancet"},{"key":"ref19","first-page":"1030","article-title":"Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique.","volume":"57","author":"TH Huang","year":"1997","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/sj.onc.1207076","article-title":"<italic>PMP24<\/italic>, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model.","volume":"23","author":"M Wu","year":"2004","journal-title":"Oncogene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1083\/jcb.200409099","article-title":"Cytokine-driven cell cycling is mediated through Cdc25A.","volume":"169","author":"AR Khaled","year":"2005","journal-title":"J Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1093\/nar\/20.24.6605","article-title":"Cloning and characterization of rad21 an essential gene of <italic>Schizosaccharomyces pombe<\/italic> involved in DNA double-strand-break repair.","volume":"20","author":"RP Birkenbihl","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1021\/bi047721l","article-title":"Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6.","volume":"44","author":"CG Van Horn","year":"2005","journal-title":"Biochemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0952-3278(02)00261-2","article-title":"Role of stearoyl-coenzyme A desaturase in lipid metabolism.","volume":"68","author":"M Miyazaki","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.modgep.2007.09.005","article-title":"The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.","volume":"8","author":"A Kuzmin","year":"2008","journal-title":"Gene Expr Patterns"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1158\/0008-5472.CAN-05-1150","article-title":"WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.","volume":"65","author":"RI Aqeilan","year":"2005","journal-title":"Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.reprotox.2007.01.004","article-title":"Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases.","volume":"23","author":"SM Ho","year":"2007","journal-title":"Reprod Toxicol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.","volume":"93","author":"JG Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mutage\/gem043","article-title":"Correlation between biomarkers of human exposure to genotoxins with focus on carcinogen-DNA adducts.","volume":"23","author":"E Gyorffy","year":"2008","journal-title":"Mutagenesis"},{"key":"ref30","first-page":"1","article-title":"A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds.","volume":"36","author":"RW Godschalk","year":"2003","journal-title":"J Biochem Mol Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1074-7613(02)00314-X","article-title":"Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.","volume":"16","author":"D-U Lee","year":"2002","journal-title":"Immunity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0952-7915(98)80174-X","article-title":"Long-range transcriptional regulation of cytokine gene expression.","volume":"10","author":"S Agarwal","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"28177","DOI":"10.1074\/jbc.M502038200","article-title":"A critical control element for interleukin-4 memory expression in T helper lymphocytes.","volume":"280","author":"LO Tykocinski","year":"2005","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1038\/sj.emboj.7601148","article-title":"Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.","volume":"25","author":"B Jones","year":"2006","journal-title":"EMBO J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/toxsci\/kfm290","article-title":"Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production <italic>in vivo<\/italic>.","volume":"102","author":"J Liu","year":"2007","journal-title":"Toxicol Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1194\/jlr.E400002-JLR200","article-title":"Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.","volume":"45","author":"DG Mashek","year":"2004","journal-title":"J Lipid Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-1119(01)00714-4","article-title":"Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene.","volume":"278","author":"H Minekura","year":"2001","journal-title":"Gene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"16748","DOI":"10.1074\/jbc.271.28.16748","article-title":"Molecular characterization and expression of rat acyl-CoA synthetase 3.","volume":"271","author":"T Fujino","year":"1996","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3230001","article-title":"Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signaling.","volume":"323(Pt 1)","author":"NJ Faergeman","year":"1997","journal-title":"Biochem J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0163-7827(03)00051-1","article-title":"Enzymes of triacylglycerol synthesis and their regulation.","volume":"43","author":"RA Coleman","year":"2004","journal-title":"Prog Lipid Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-3-1","article-title":"Arachidonoyl-phospholipid remodeling in proliferating murine T cells.","volume":"3","author":"M Tomita","year":"2004","journal-title":"Lipids Health Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02719294","article-title":"Acyl CoA synthetase from rat lung: purification and properties.","volume":"160","author":"DK Das","year":"1982","journal-title":"Lung"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/jnci\/dji133","article-title":"p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.","volume":"97","author":"T Mashima","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1034\/j.1399-3038.2003.00022.x","article-title":"Fatty acids in breast milk of allergic and non-allergic mothers: The PIAMA birth cohort study.","volume":"14","author":"A Wijga","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1399-3038.2005.00340.x","article-title":"Atopy, eczema and breast milk fatty acids in a high-risk cohort of children followed from birth to 5 yr.","volume":"17","author":"WH Oddy","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11883-004-0087-5","article-title":"Omega-3 fatty acids and inflammation.","volume":"6","author":"TA Mori","year":"2004","journal-title":"Curr Atheroscler Rep"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/thorax.2003.009498","article-title":"Fatty acid levels and risk of asthma in young adults.","volume":"59","author":"RK Woods","year":"2004","journal-title":"Thorax"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1651-2227.2000.tb01329.x","article-title":"Abnormal fatty acid composition in umbilical cord blood of infants at high risk of atopic disease.","volume":"89","author":"M Beck","year":"2000","journal-title":"Acta Paediatr"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1183\/09031936.00162206","article-title":"Scores of asthma and asthma severity reveal new regions of linkage in EGEA study families.","volume":"30(2)","author":"E Bouzigon","year":"2007","journal-title":"Eur Respir J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00439-008-0495-7","article-title":"Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region.","volume":"123(5)","author":"S Choudhry","year":"2008","journal-title":"Hum Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10654-005-1048-1","article-title":"Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life.","volume":"20","author":"W Jedrychowski","year":"2005","journal-title":"Eur J Epidemiol"}],"updated-by":[{"DOI":"10.1371\/annotation\/6a678269-9623-4a13-8b19-4e9431ff3cb6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2009,8,18]],"date-time":"2009-08-18T00:00:00Z","timestamp":1250553600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T17:59:09Z","timestamp":1540317549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004488"}},"subtitle":[],"editor":[{"given":"Catherine M.","family":"Suter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,2,16]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004488","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/6a678269-9623-4a13-8b19-4e9431ff3cb6","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,16]]}}}