{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:56:42Z","timestamp":1761292602016},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T00:00:00Z","timestamp":1236729600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004800","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T22:30:45Z","timestamp":1236724245000},"page":"e4800","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Toll-Like Receptor 4 (TLR4) and Typhoid Fever in Vietnam"],"prefix":"10.1371","volume":"4","author":[{"given":"Nguyen Thi","family":"Hue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Ngoc","family":"Lanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha","family":"Vinh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Tran","family":"Chinh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Tinh","family":"Hien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen T.","family":"Hieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy J.","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid Fever.","volume":"347","author":"CM Parry","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","first-page":"346","article-title":"The global burden of typhoid fever.","volume":"82","author":"JA Crump","year":"2004","journal-title":"Bull World Health Organ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.124.1.20","article-title":"Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.","volume":"124","author":"AD O'Brien","year":"1980","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/2191253a0","article-title":"Genetic control of leucocyte responses to endotoxin.","volume":"219","author":"BM Sultzer","year":"1968","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene.","volume":"282","author":"A Poltorak","year":"1998","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.","volume":"162","author":"K Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/09680519010070060901","article-title":"LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.","volume":"7","author":"M Bernheiden","year":"2001","journal-title":"J Endotoxin Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.4049\/jimmunol.172.7.4463","article-title":"Toll-like receptors are temporally involved in host defense.","volume":"172","author":"DS Weiss","year":"2004","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling.","volume":"4","author":"S Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity.","volume":"2","author":"S Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.","volume":"25","author":"NC Arbour","year":"2000","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1084\/jem.20022078","article-title":"Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.","volume":"197","author":"C Erridge","year":"2003","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/archinte.162.9.1028","article-title":"Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock.","volume":"162","author":"E Lorenz","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1086\/420830","article-title":"Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.","volume":"189","author":"G Tal","year":"2004","journal-title":"J Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1073\/pnas.0409831102","article-title":"Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.","volume":"102","author":"TR Hawn","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.0506803102","article-title":"Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.","volume":"103","author":"FP Mockenhaupt","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tube.2004.02.001","article-title":"The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia.","volume":"84","author":"MJ Newport","year":"2004","journal-title":"Tuberculosis (Edinb)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1086\/322798","article-title":"A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.","volume":"184","author":"RC Read","year":"2001","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.1031605100","article-title":"Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.","volume":"100","author":"I Smirnova","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/genetics\/158.4.1657","article-title":"Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.","volume":"158","author":"I Smirnova","year":"2001","journal-title":"Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1086\/428593","article-title":"Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam.","volume":"191","author":"SJ Dunstan","year":"2005","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1086\/317940","article-title":"Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam.","volume":"183","author":"SJ Dunstan","year":"2001","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1473-3099(05)70023-2","article-title":"Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.","volume":"5","author":"NW Schroder","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1600-065X.2002.19002.x","article-title":"Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease.","volume":"190","author":"R Lazarus","year":"2002","journal-title":"Immunol Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors.","volume":"21","author":"K Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity.","volume":"1","author":"R Medzhitov","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"ref27","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2000-1-1-research002","article-title":"Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4).","volume":"1","author":"I Smirnova","year":"2000","journal-title":"Genome Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/4371233a","article-title":"Deeper into the genome.","volume":"437","author":"R Gibbs","year":"2005","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1093\/hmg\/11.20.2417","article-title":"The allelic architecture of human disease genes: common disease-common variant.or not?","volume":"11","author":"JK Pritchard","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0168-9525(01)02410-6","article-title":"On the allelic spectrum of human disease.","volume":"17","author":"DE Reich","year":"2001","journal-title":"Trends Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1529-8817.2005.00180.x","article-title":"A comparison of case-control and family-based association methods: the example of sickle-cell and malaria.","volume":"69","author":"H Ackerman","year":"2005","journal-title":"Ann Hum Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1086\/340516","article-title":"IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.","volume":"185","author":"O Koch","year":"2002","journal-title":"J Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(02)08516-1","article-title":"MBL genotype and risk of invasive pneumococcal disease: a case-control study.","volume":"359","author":"S Roy","year":"2002","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nature07632","article-title":"A global network for investigating the genomic epidemiology of malaria.","volume":"456","year":"2008","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.","volume":"388","author":"R Medzhitov","year":"1997","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll.","volume":"95","author":"FL Rock","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","first-page":"362","article-title":"Three novel mammalian toll-like receptors: gene structure, expression, and evolution.","volume":"11","author":"X Du","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1182\/blood.V91.11.4020","article-title":"Cloning and characterization of two Toll\/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.","volume":"91","author":"PM Chaudhary","year":"1998","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition.","volume":"20","author":"CA Janeway Jr","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/BJ20041243","article-title":"Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression.","volume":"387","author":"T Roger","year":"2005","journal-title":"Biochem J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.4049\/jimmunol.173.11.6949","article-title":"Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling.","volume":"173","author":"N Hyakushima","year":"2004","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1161\/01.ATV.0000101191.92392.1D","article-title":"Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.","volume":"23","author":"N Ameziane","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bbrc.2006.01.074","article-title":"Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain.","volume":"341","author":"T Nishiya","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1042\/bst0310652","article-title":"Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.","volume":"31","author":"NJ Child","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/jmg.2004.021600","article-title":"TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury.","volume":"41","author":"RC Barber","year":"2004","journal-title":"J Med Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/01.inf.0000095431.15606.68","article-title":"Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.","volume":"22","author":"A Allen","year":"2003","journal-title":"Pediatr Infect Dis J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T09:56:29Z","timestamp":1710150989000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004800"}},"subtitle":[],"editor":[{"given":"J\u00f6rg Hermann","family":"Fritz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,3,11]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004800","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,11]]}}}