{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:00:36Z","timestamp":1793037636807,"version":"4.5.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T00:00:00Z","timestamp":1237939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0004962","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T23:05:58Z","timestamp":1237935958000},"page":"e4962","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Neuroendocrine Disturbances in Huntington's Disease"],"prefix":"10.1371","volume":"4","author":[{"given":"Nadine","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Moutereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Krystkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Azulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tranchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Broussolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Maison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease.","volume":"44","author":"JP Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref3","first-page":"241","article-title":"Cognitive impairments in Huntington's disease:insights into the neuropsychology of striatum","author":"J Brandt","year":"1991"},{"key":"ref4","first-page":"213","article-title":"Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study.","volume":"75","author":"J Kassubek","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005072-199007000-00002","article-title":"Atrophy of the hypothalamic lateral tuberal nucleus in Huntington's disease.","volume":"49","author":"HP Kremer","year":"1990","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0304-3940(91)90443-W","article-title":"The hypothalamic lateral tuberal nucleus and the characteristics of neuronal loss in Huntington's disease.","volume":"132","author":"HP Kremer","year":"1991","journal-title":"Neurosci Lett"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/hmg\/ddi004","article-title":"Orexin loss in Huntington's disease.","volume":"14","author":"A Petersen","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000074445","article-title":"Neuroendocrinology of neurodegenerative diseases. Insights from transgenic mouse models.","volume":"78","author":"JL Gonzalez De Aguilar","year":"2003","journal-title":"Neuroendocrinology"},{"key":"ref9","first-page":"551","article-title":"Plasma growth hormone concentrations in Huntington's chorea.","volume":"50","author":"OT Phillipson","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jnnp.41.2.135","article-title":"Growth hormone and prolactin response to bromocriptine in patients with Huntington's chorea.","volume":"41","author":"RJ Chalmers","year":"1978","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1210\/jcem-44-5-870","article-title":"Altered growth hormone and prolactin responses to dopaminergic stimulation in Huntington's chorea.","volume":"44","author":"T Caraceni","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/jcem-39-1-36","article-title":"Growth hormone abnormalities in Huntington's chorea: effect of L-dopa administration.","volume":"39","author":"S Podolsky","year":"1974","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1210\/jcem-41-1-160","article-title":"Exaggerated growth hormone response to arginine infusion in Huntington's disease.","volume":"41","author":"NA Leopold","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(77)90608-0","article-title":"Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess.","volume":"2","author":"MR Hayden","year":"1977","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0024-3205(78)90616-1","article-title":"Neuroendocrine function in Huntington's disease: dopaminergic regulation of prolactin release.","volume":"22","author":"E Caine","year":"1978","journal-title":"Life Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0024-3205(79)90357-6","article-title":"Growth hormone and prolactin secretion in Huntington's disease.","volume":"24","author":"CL Levy","year":"1979","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0022-510X(95)00114-H","article-title":"Serum dehydroepiandrosterone and cortisol measurements in Huntington's chorea.","volume":"132","author":"F Leblhuber","year":"1995","journal-title":"J Neurol Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0006-3223(91)90007-9","article-title":"The limbic-hypothalamic-pituitary-adrenal axis in Huntington's disease.","volume":"30","author":"IJ Heuser","year":"1991","journal-title":"Biol Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/jnnp.44.5.414","article-title":"Studies of hypothalamic function in Huntington's chorea.","volume":"44","author":"PJ Lavin","year":"1981","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.20428","article-title":"Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia.","volume":"57","author":"M Markianos","year":"2005","journal-title":"Ann Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","article-title":"The IGF-1\/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.","volume":"2","author":"S Humbert","year":"2002","journal-title":"Dev Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.molcel.2004.09.016","article-title":"A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.","volume":"15","author":"H Goehler","year":"2004","journal-title":"Mol Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1212\/01.WNL.0000031791.10922.CF","article-title":"Weight loss in early stage of Huntington's disease.","volume":"59","author":"L Djousse","year":"2002","journal-title":"Neurology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5694\/j.1326-5377.1981.tb135681.x","article-title":"Body weight and dietary factors in Huntington's disease patients compared with matched controls.","volume":"1","author":"PR Sanberg","year":"1981","journal-title":"Med J Aust"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(73)91697-8","article-title":"Pathogenesis of Huntington's chorea.","volume":"1","author":"GW Bruyn","year":"1973","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1212\/01.wnl.0000334276.09729.0e","article-title":"Weight loss in Huntington disease increases with higher CAG repaet number.","volume":"71","author":"NA Aziz","year":"2008","journal-title":"Neurology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1507\/endocrj.52.213","article-title":"TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients.","volume":"52","author":"A Oge","year":"2005","journal-title":"Endocr J"},{"key":"ref28","first-page":"223","article-title":"Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications.","volume":"18","author":"NA Aziz","year":"2007","journal-title":"Rev Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0140-6736(77)90272-0","article-title":"Prolactin control in Huntington's chorea.","volume":"2","author":"EE Muller","year":"1977","journal-title":"Lancet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0889-8529(03)00005-7","article-title":"Endocrine evaluation of patients with critical illness.","volume":"32","author":"G Van den Berghe","year":"2003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000098367","article-title":"Increased levels of nitric oxide, cortisol and adrenomedullin in patients with chronic schizophrenia.","volume":"16","author":"N Yilmaz","year":"2007","journal-title":"Med Princ Pract"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archpsyc.57.10.925","article-title":"Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.","volume":"57","author":"RM Sapolsky","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1176\/jnp.6.2.147","article-title":"Sexual disorders in Huntington's disease.","volume":"6","author":"JP Fedoroff","year":"1994","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Bates GP.Formation of polyglutamine inclusions in non-CNS tissue.","volume":"8","author":"K Sathasivam","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1460-9568.2005.04324.x","article-title":"Reduction of GnRH and infertility in the R6\/2 mouse model of Huntington's disease.","volume":"22","author":"E Papalexi","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/0024-3205(80)90364-1","article-title":"Circadian rhythmicity of prolactin secretion in Huntington's chorea.","volume":"26","author":"A Polleri","year":"1980","journal-title":"Life Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1530\/eje.0.1510451","article-title":"Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease.","volume":"151","author":"V Popovic","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1210\/jc.2003-030840","article-title":"Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a Metaanalysis of Blinded, Randomized, Placebo-Controlled Trials.","volume":"89","author":"P Maison","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0031-6865(99)00037-0","article-title":"Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke.","volume":"74","author":"S Dore","year":"2000","journal-title":"Pharm Acta Helv"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/nbdi.2000.0311","article-title":"Neurodegeneration is associated to changes in serum insulin-like growth factors.","volume":"7","author":"S Busiguina","year":"2000","journal-title":"Neurobiol Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency.","volume":"11","year":"1996","journal-title":"Mov Disord"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1212\/WNL.31.10.1333","article-title":"Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs.","volume":"31","author":"I Shoulson","year":"1981","journal-title":"Neurology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s004310050707","article-title":"Magnetic resonance images of 91 children with different causes of short stature: pituitary size reflects growth hormone secretion.","volume":"156","author":"BHP Nagel","year":"1997","journal-title":"Eur J Pediatr"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0004962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:59:29Z","timestamp":1589680769000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0004962"}},"subtitle":[],"editor":[{"given":"Hitoshi","family":"Okazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,3,25]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0004962","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,25]]}}}