{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:04:16Z","timestamp":1791176656850,"version":"4.1.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005193","type":"journal-article","created":{"date-parts":[[2009,4,13]],"date-time":"2009-04-13T22:48:26Z","timestamp":1239662906000},"page":"e5193","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["ARF6-Mediated Endosome Recycling Reverses Lipid Accumulation Defects in Niemann-Pick Type C Disease"],"prefix":"10.1371","volume":"4","author":[{"given":"Jill Kuglin","family":"Schweitzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean D.","family":"Pietrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crislyn","family":"D'Souza-Schorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cellbio.22.010305.104656","article-title":"Cholesterol sensing, trafficking, and esterification.","volume":"22","author":"TY Chang","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.semcdb.2004.03.001","article-title":"Cellular pathology of niemann-pick type C disease.","volume":"15(4)","author":"E Ikonen","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbalip.2004.08.008","article-title":"Intracellular trafficking of niemann-pick C proteins 1 and 2: Obligate components of subcellular lipid transport.","volume":"1685(1\u20133)","author":"L Liscum","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"41309","DOI":"10.1074\/jbc.M008272200","article-title":"Fate of endogenously synthesized cholesterol in niemann-pick type C1 cells.","volume":"275(52)","author":"JC Cruz","year":"2000","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"43564","DOI":"10.1074\/jbc.M107938200","article-title":"Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes\/lysosomes.","volume":"276(47)","author":"W Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"32569","DOI":"10.1074\/jbc.M304553200","article-title":"Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human niemann-pick type C disease.","volume":"278(35)","author":"HY Choi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"22525","DOI":"10.1074\/jbc.M700326200","article-title":"Differential regulation of ATP binding cassette protein A1 expression and ApoA-I lipidation by niemann-pick type C1 in murine hepatocytes and macrophages.","volume":"282(31)","author":"MD Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0854.2006.00513.x","article-title":"Sterol, protein and lipid trafficking in chinese hamster ovary cells with niemann-pick type C1 defect.","volume":"8(2)","author":"NH Pipalia","year":"2007","journal-title":"Traffic"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4419-9019-8_4","article-title":"Fitting a mathematical model to biological data: Intracellular trafficking in niemann-pick C disease.","volume":"537","author":"ME Wastney","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrm1910","article-title":"ARF proteins: Roles in membrane traffic and beyond.","volume":"7(5)","author":"C D'Souza-Schorey","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1091\/mbc.E04-02-0151","article-title":"Characterization of a nonclathrin endocytic pathway: Membrane cargo and lipid requirements.","volume":"15(8)","author":"N Naslavsky","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1016\/S0021-9258(18)80136-3","article-title":"The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one.","volume":"264(20)","author":"L Liscum","year":"1989","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","article-title":"Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.","volume":"1(2)","author":"T Kobayashi","year":"1999","journal-title":"Nat Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbalip.2004.08.009","article-title":"Lipid and cholesterol trafficking in NPC.","volume":"1685(1\u20133)","author":"S Mukherjee","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1194\/jlr.D200036-JLR200","article-title":"Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and niemann-pick type C1 cells.","volume":"44(5)","author":"S Sugii","year":"2003","journal-title":"J Lipid Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"27210","DOI":"10.1074\/jbc.M201569200","article-title":"Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis.","volume":"277(30)","author":"JK Schweitzer","year":"2002","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1098\/rstb.2003.1275","article-title":"Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases.","volume":"358(1433)","author":"RE Pagano","year":"2003","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1091\/mbc.E04-05-0432","article-title":"Elevated endosomal cholesterol levels in niemann-pick cells inhibit rab4 and perturb membrane recycling.","volume":"15(10)","author":"A Choudhury","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1091\/mbc.E02-01-0025","article-title":"Modulation of cellular cholesterol transport and homeostasis by Rab11.","volume":"13(9)","author":"M Holtta-Vuori","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1091\/mbc.e06-07-0575","article-title":"Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells.","volume":"18(1)","author":"MD Linder","year":"2007","journal-title":"Mol Biol Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/emboj\/21.6.1289","article-title":"Late endosome motility depends on lipids via the small GTPase Rab7.","volume":"21(6)","author":"C Lebrand","year":"2002","journal-title":"Embo J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"17890","DOI":"10.1074\/jbc.M601679200","article-title":"Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.","volume":"281(26)","author":"IG Ganley","year":"2006","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1172\/JCI0215420","article-title":"Rab proteins mediate golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in niemann-pick C cells.","volume":"109(12)","author":"A Choudhury","year":"2002","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1096\/fj.04-2714fje","article-title":"Protein transduction of Rab9 in niemann-pick C cells reduces cholesterol storage.","volume":"19(11)","author":"K Narita","year":"2005","journal-title":"Faseb J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1194\/jlr.M200230-JLR200","article-title":"Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from niemann-pick C1 late endosomes.","volume":"44(2)","author":"M Walter","year":"2003","journal-title":"J Lipid Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2353\/ajpath.2009.080660","article-title":"Development of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of niemann-pick type C disease.","volume":"174(1)","author":"T Kaptzan","year":"2009","journal-title":"Am J Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1093\/emboj\/20.17.4973","article-title":"An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.","volume":"20(17)","author":"F Palacios","year":"2001","journal-title":"Embo J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yexcr.2005.07.033","article-title":"A requirement for ARF6 during the completion of cytokinesis.","volume":"311(1)","author":"JK Schweitzer","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1128\/MCB.20.10.3685-3694.2000","article-title":"ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.","volume":"20(10)","author":"RL Boshans","year":"2000","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T03:46:09Z","timestamp":1633319169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005193"}},"subtitle":[],"editor":[{"given":"Jean","family":"Gruenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,14]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005193","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,14]]}}}