{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:30:48Z","timestamp":1764700248696},"reference-count":100,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005198","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T23:04:02Z","timestamp":1239145442000},"page":"e5198","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Host Iron Binding Proteins Acting as Niche Indicators for Neisseria meningitidis"],"prefix":"10.1371","volume":"4","author":[{"given":"Philip W.","family":"Jordan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel J.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00013542-199801000-00004","article-title":"Prevention of meningococcal disease: present and future.","volume":"9","author":"CMGJ Ferreiros","year":"1998","journal-title":"Rev Med Micro"},{"key":"ref2","first-page":"1","article-title":"Iron in biological systems.","author":"E Griffiths","year":"1999"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1009227206890","article-title":"Salicylic acid is not a bacterial siderophore: a theoretical study.","volume":"13","author":"JR Chipperfield","year":"2000","journal-title":"Biometals"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9542","DOI":"10.1073\/pnas.1033001100","article-title":"Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of <italic>Neisseria meningitidis<\/italic> group B.","volume":"100","author":"R Grifantini","year":"2003","journal-title":"PNAS"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1128\/JB.187.14.4865-4874.2005","article-title":"Identification of the iron-responsive genes of <italic>Neisseria gonorrhoeae<\/italic> by microarray analysis in defined medium.","volume":"187","author":"TF Ducey","year":"2005","journal-title":"J Bacteriol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1073\/pnas.80.8.2263","article-title":"Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.","volume":"80","author":"RD Klausner","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/IAI.39.1.50-59.1983","article-title":"Turnover in the transferrin iron pool during the hypoferremic phase of experimental <italic>Neisseria meningitidis<\/italic> infection in mice.","volume":"39","author":"ED Letendre","year":"1983","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00916041","article-title":"Levels of messenger ribonucleic acids for plasma proteins in rat liver during acute experimental inflammation.","volume":"10","author":"G Schreiber","year":"1986","journal-title":"Inflammation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1016\/S0021-9258(19)83875-9","article-title":"Transcriptional regulation of plasma protein synthesis during inflammation.","volume":"261","author":"HE Birch","year":"1986","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/BF02151559","article-title":"Immunohistochemical localization of the iron-binding protein lactoferrin in human bronchial glands.","volume":"21","author":"P Masson","year":"1965","journal-title":"Experientia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/IAI.56.11.2774-2781.1988","article-title":"Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin.","volume":"56","author":"RT Ellison 3rd","year":"1988","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1128\/IAI.62.6.2628-2632.1994","article-title":"Lactoferrin is a lipid A-binding protein.","volume":"62","author":"BJ Appelmelk","year":"1994","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2672.1992.tb05007.x","article-title":"Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin.","volume":"73","author":"W Bellamy","year":"1992","journal-title":"J Appl Bacteriol"},{"key":"ref14","article-title":"Interactions of bovine lactoferricin with acidic phospholipid bilayers and its antimicrobial activity as studied by solid-state NMR.","author":"M Umeyama","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/417552a","article-title":"A component of innate immunity prevents bacterial biofilm development.","volume":"417","author":"PK Singh","year":"2002","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1365-2958.2003.03327.x","article-title":"Human milk lactoferrin is a serine protease that cleaves <italic>Haemophilus<\/italic> surface proteins at arginine-rich sites.","volume":"47","author":"DR Hendrixson","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1046\/j.1365-2958.1999.01411.x","article-title":"Iron acquisition systems in the pathogenic <italic>Neisseria<\/italic>.","volume":"32","author":"AB Schryvers","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1128\/IAI.56.12.3132-3138.1988","article-title":"Loss of transferrin receptor activity in <italic>Neisseria meningitidis<\/italic> correlates with inability to use transferrin as an iron source.","volume":"56","author":"J Tsai","year":"1988","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/IAI.61.2.751-759.1993","article-title":"Localization of the meningococcal receptors for human transferrin.","volume":"61","author":"DA Ala'Aldeen","year":"1993","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/mpat.1994.1085","article-title":"Molecular characterization of the structural gene for the lactoferrin receptor of the meningococcal strain H44\/76.","volume":"17","author":"A Pettersson","year":"1994","journal-title":"Microb Pathog"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2958.1997.2501619.x","article-title":"Molecular characterization of <italic>hpuAB<\/italic>, the haemoglobin-haptoglobin-utilization operon of <italic>Neisseria meningitidis<\/italic>.","volume":"23","author":"LA Lewis","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/IAI.56.4.977-983.1988","article-title":"A pleiotropic iron-uptake mutant of <italic>Neisseria meningitidis<\/italic> lacks a 70-kilodalton iron-regulated protein.","volume":"56","author":"DW Dyer","year":"1988","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/IAI.33.2.555-564.1981","article-title":"Ability of <italic>Neisseria gonorrhoeae<\/italic>, <italic>Neisseria meningitidis<\/italic>, and commensal <italic>Neisseria<\/italic> species to obtain iron from transferrin and iron compounds.","volume":"33","author":"PA Mickelsen","year":"1981","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1574-6968.1979.tb04300.x","article-title":"Removal of iron from human transferrin by <italic>Neisseria meningitidis<\/italic>.","volume":"6","author":"FS Archibald","year":"1979","journal-title":"FEMS Microbiol Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1128\/jb.178.15.4670-4678.1996","article-title":"HmbR outer membrane receptors of pathogenic <italic>Neisseria<\/italic> spp.: iron-regulated, hemoglobin-binding proteins with a high level of primary structure conservation.","volume":"178","author":"I Stojiljkovic","year":"1996","journal-title":"J Bacteriol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1128\/IAI.35.3.915-920.1982","article-title":"Ability of <italic>Neisseria gonorrhoeae, Neisseria meningitidis<\/italic>, and commensal <italic>Neisseria<\/italic> species to obtain iron from lactoferrin.","volume":"35","author":"PA Mickelsen","year":"1982","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1128\/JB.181.7.2067-2074.1999","article-title":"HmbR, a Hemoglobin-Binding Outer Membrane Protein of <italic>Neisseria meningitidis<\/italic>, Undergoes Phase Variation.","volume":"181","author":"AR Richardson","year":"1999","journal-title":"J Bacteriol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1365-2958.2000.02000.x","article-title":"Repeat-associated phase variable genes in the complete genome sequence of <italic>Neisseria meningitidis<\/italic> strain MC58.","volume":"37","author":"NJ Saunders","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2958.1997.5381914.x","article-title":"Energy-dependent changes in the gonococcal transferrin receptor.","volume":"26","author":"CN Cornelissen","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1128\/jb.179.3.805-812.1997","article-title":"<italic>Neisseria meningitidis tonB<\/italic>, <italic>exbB<\/italic>, and <italic>exbD<\/italic> genes: Ton-dependent utilization of protein-bound iron in Neisseriae.","volume":"179","author":"I Stojiljkovic","year":"1997","journal-title":"J Bacteriol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2958.1997.3421692.x","article-title":"Cloning and functional characterization of <italic>Neisseria gonorrhoeae tonB, exbB<\/italic> and <italic>exbD<\/italic> genes.","volume":"24","author":"GD Biswas","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1128\/IAI.72.5.2494-2506.2004","article-title":"Analysis of haptoglobin and hemoglobin-haptoglobin interactions with the <italic>Neisseria meningitidis<\/italic> TonB-dependent receptor HpuAB by flow cytometry.","volume":"72","author":"KH Rohde","year":"2004","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1365-2958.2002.02745.x","article-title":"Interactions of haemoglobin with the <italic>Neisseria meningitidis<\/italic> receptor HpuAB: the role of TonB and an intact proton motive force.","volume":"43","author":"KH Rohde","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1128\/IAI.66.5.2330-2336.1998","article-title":"A <italic>Neisseria meningitidis fbpABC<\/italic> Mutant Is Incapable of Using Nonheme Iron for Growth.","volume":"66","author":"HH Khun","year":"1998","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/jb.178.7.2145-2149.1996","article-title":"The <italic>fbpABC<\/italic> locus of <italic>Neisseria gonorrhoeae<\/italic> functions in the periplasm-to-cytosol transport of iron.","volume":"178","author":"P Adhikari","year":"1996","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2958.1993.tb01957.x","article-title":"The ferric iron-binding protein of pathogenic <italic>Neisseria<\/italic> spp. functions as a periplasmic transport protein in iron acquisition from human transferrin.","volume":"10","author":"CY Chen","year":"1993","journal-title":"Mol Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1128\/IAI.70.3.1461-1467.2002","article-title":"Replication of <italic>Neisseria meningitidis<\/italic> within Epithelial Cells Requires TonB-Dependent Acquisition of Host Cell Iron.","volume":"70","author":"JA Larson","year":"2002","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1365-2958.2004.04169.x","article-title":"<italic>Neisseria meningitidis<\/italic> accelerates ferritin degradation in host epithelial cells to yield an essential iron source.","volume":"53","author":"JA Larson","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1128\/jb.177.5.1299-1306.1995","article-title":"Identification of an iron-regulated outer membrane protein of <italic>Neisseria meningitidis<\/italic> involved in the utilization of hemoglobin complexed to haptoglobin.","volume":"177","author":"L Lewis","year":"1995","journal-title":"J Bacteriol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"29478","DOI":"10.1074\/jbc.M303381200","article-title":"Global iron-dependent gene regulation in <italic>Escherichia coli<\/italic>. A new mechanism for iron homeostasis.","volume":"278","author":"JP McHugh","year":"2003","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1099\/mic.0.27412-0","article-title":"<italic>Campylobacter jejuni<\/italic> gene expression in response to iron limitation and the role of Fur.","volume":"151","author":"K Holmes","year":"2005","journal-title":"Microbiology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1432-1033.1981.tb06357.x","article-title":"Citrate-dependent iron transport system in <italic>Escherichia coli<\/italic> K-12.","volume":"117","author":"S Hussein","year":"1981","journal-title":"Eur J Biochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2958.1995.tb02226.x","article-title":"Regulation of citrate-dependent iron transport of <italic>Escherichia coli<\/italic>: <italic>fecR<\/italic> is required for transcription activation by FecI.","volume":"15","author":"M Ochs","year":"1995","journal-title":"Mol Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/JB.182.3.637-646.2000","article-title":"Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins.","volume":"182","author":"S Enz","year":"2000","journal-title":"J Bacteriol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1128\/JB.185.6.1796-1802.2003","article-title":"The FecI extracytoplasmic-function sigma factor of <italic>Escherichia coli<\/italic> interacts with the beta&apos; subunit of RNA polymerase.","volume":"185","author":"S Mahren","year":"2003","journal-title":"J Bacteriol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"9876","DOI":"10.1073\/pnas.91.21.9876","article-title":"Iron acquisition from heme and hemoglobin by a <italic>Serratia marcescens<\/italic> extracellular protein.","volume":"91","author":"S Letoffe","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.1365-2958.2004.04207.x","article-title":"Haemophore-mediated signalling in <italic>Serratia marcescens<\/italic>: a new mode of regulation for an extra cytoplasmic function (ECF) sigma factor involved in haem acquisition.","volume":"53","author":"F Biville","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1128\/JB.184.23.6714-6720.2002","article-title":"Transcriptional Response of <italic>Pasteurella multocida<\/italic> to Defined Iron Sources.","volume":"184","author":"ML Paustian","year":"2002","journal-title":"J Bacteriol"},{"key":"ref49","first-page":"254","article-title":"Battling against host phagocytes: the wherefore of the RTX family of toxins?","volume":"4","author":"RA Welch","year":"1995","journal-title":"Infect Agents Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1073\/pnas.96.3.1071","article-title":"Identification of a <italic>Vibrio cholerae<\/italic> RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.","volume":"96","author":"W Lin","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1128\/IAI.61.7.2906-2911.1993","article-title":"The RTX cytotoxin-related FrpA protein of <italic>Neisseria meningitidis<\/italic> is secreted extracellularly by meningococci and by HlyBD+ <italic>Escherichia coli<\/italic>.","volume":"61","author":"SA Thompson","year":"1993","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2958.1993.tb01671.x","article-title":"Cloning and nucleotide sequence of <italic>frpC<\/italic>, a second gene from <italic>Neisseria meningitidis<\/italic> encoding a protein similar to RTX cytotoxins.","volume":"9","author":"SA Thompson","year":"1993","journal-title":"Mol Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/infdis\/143.4.525","article-title":"Attachment of <italic>Neisseria meningitidis<\/italic> to human mucosal surfaces: influence of pili and type of receptor cell.","volume":"143","author":"DS Stephens","year":"1981","journal-title":"J Infect Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.1996.01551.x","article-title":"Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae.","volume":"22","author":"M Virji","year":"1996","journal-title":"Mol Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2958.1996.01548.x","article-title":"The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of <italic>Neisseria meningitidis<\/italic> and <italic>Neisseria gonorrhoeae<\/italic>.","volume":"22","author":"M Virji","year":"1996","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1084\/jem.182.2.511","article-title":"Adherence of pilus- Opa+ gonococci to epithelial cells in vitro involves heparan sulfate.","volume":"182","author":"T Chen","year":"1995","journal-title":"J Exp Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1099\/00221287-114-2-305","article-title":"Variations in surface protein composition associated with virulence properties in opacity types of <italic>Neisseria gonorrhoeae<\/italic>.","volume":"114","author":"PR Lambden","year":"1979","journal-title":"J Gen Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/IAI.21.2.575-584.1978","article-title":"Studies on gonococcus infection. XV. Identification of surface proteins of <italic>Neisseria gonorrhoeae<\/italic> correlated with leukocyte association.","volume":"21","author":"GJ King","year":"1978","journal-title":"Infect Immun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1111\/j.1462-5822.2007.01038.x","article-title":"IFN-gamma amplifies NFkappaB-dependent <italic>Neisseria meningitidis<\/italic> invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.","volume":"9","author":"NJ Griffiths","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1462-5822.2006.00775.x","article-title":"Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant <italic>Neisseria meningitidis<\/italic>.","volume":"9","author":"HA Rowe","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-1097(97)00135-3","article-title":"Cloning and characterization of the <italic>Neisseria meningitidis rfaC<\/italic> gene encoding alpha-1,5 heptosyltransferase I.","volume":"151","author":"I Stojiljkovic","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"33115","DOI":"10.1074\/jbc.M607056200","article-title":"Coordinated regulation of the <italic>Neisseria gonorrhoeae<\/italic>-truncated denitrification pathway by the nitric oxide-sensitive repressor, NsrR, and nitrite-insensitive NarQ-NarP.","volume":"281","author":"TW Overton","year":"2006","journal-title":"J Biol Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0928-8244(99)00113-3","article-title":"Nitric oxide participates in the immune response against <italic>Neisseria meningitidis<\/italic> serogroup B.","volume":"25","author":"J Padron","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"19939","DOI":"10.1074\/jbc.M601308200","article-title":"O-Acetylation of the terminal N-acetylglucosamine of the lipooligosaccharide inner core in <italic>Neisseria meningitidis<\/italic>. Influence on inner core structure and assembly.","volume":"281","author":"CM Kahler","year":"2006","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"50853","DOI":"10.1074\/jbc.M308364200","article-title":"Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.","volume":"278","author":"S Ram","year":"2003","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1128\/JB.01807-05","article-title":"Comparison of the RpoH-dependent regulon and general stress response in <italic>Neisseria gonorrhoeae<\/italic>.","volume":"188","author":"IC Gunesekere","year":"2006","journal-title":"J Bacteriol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1574-695X.2000.tb01494.x","article-title":"Identification and characterisation of a novel conserved outer membrane protein from <italic>Neisseria meningitidis<\/italic>.","volume":"28","author":"IR Peak","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2958.2006.05261.x","article-title":"<italic>Neisseria meningitidis<\/italic> NhhA is a multifunctional trimeric autotransporter adhesin.","volume":"61","author":"M Scarselli","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tim.2005.03.004","article-title":"Trimeric autotransporters: a distinct subfamily of autotransporter proteins.","volume":"13","author":"SE Cotter","year":"2005","journal-title":"Trends Microbiol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1084\/jem.188.5.941","article-title":"Gonococcal invasion of epithelial cells driven by P.IA, a bacterial ion channel with GTP binding properties.","volume":"188","author":"JP van Putten","year":"1998","journal-title":"J Exp Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/IAI.63.1.160-167.1995","article-title":"Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst.","volume":"63","author":"R Bjerknes","year":"1995","journal-title":"Infect Immun"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.4049\/jimmunol.172.6.3784","article-title":"Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of <italic>Neisseria meningitidis<\/italic>.","volume":"172","author":"MM Estabrook","year":"2004","journal-title":"J Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1073\/pnas.87.1.333","article-title":"Identification and characterization of a <italic>Neisseria gonorrhoeae<\/italic> gene encoding a glycolipid-binding adhesin.","volume":"87","author":"DK Paruchuri","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1365-2958.1997.2511618.x","article-title":"PilP, a pilus biogenesis lipoprotein in <italic>Neisseria gonorrhoeae<\/italic>, affects expression of PilQ as a high-molecular-mass multimer.","volume":"23","author":"SL Drake","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1365-2958.2006.05341.x","article-title":"A systematic genetic analysis in <italic>Neisseria meningitidis<\/italic> defines the Pil proteins required for assembly, functionality, stabilization and export of type IV pili.","volume":"61","author":"E Carbonnelle","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"10872","DOI":"10.1073\/pnas.95.18.10872","article-title":"Identification of the gene (<italic>lgtG<\/italic>) encoding the lipooligosaccharide beta chain synthesizing glucosyl transferase from <italic>Neisseria gonorrhoeae<\/italic>.","volume":"95","author":"A Banerjee","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","article-title":"LPS Mediated Serum Resistance in <italic>Neisseria meningitidis<\/italic>.","author":"S Ahmed","year":"2005"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2958.2004.04426.x","article-title":"Contact with host cells induces a DNA repair system in pathogenic Neisseriae.","volume":"55","author":"S Morelle","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2958.2005.04839.x","article-title":"The transcriptome response of <italic>Neisseria gonorrhoeae<\/italic> to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection.","volume":"58","author":"EA Stohl","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1128\/JB.188.7.2483-2492.2006","article-title":"Effect of <italic>Neisseria meningitidis fur<\/italic> mutations on global control of gene transcription.","volume":"188","author":"I Delany","year":"2006","journal-title":"J Bacteriol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.810892","article-title":"<italic>Neisseria gonorrhoeae<\/italic> and <italic>Neisseria meningitidis<\/italic>: extracellular enzyme cleaves human immunoglobulin A.","volume":"190","author":"AG Plaut","year":"1975","journal-title":"Science"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0014-5793(97)00163-4","article-title":"The lysosomal\/phagosomal membrane protein h-lamp-1 is a target of the IgA1 protease of <italic>Neisseria gonorrhoeae<\/italic>.","volume":"405","author":"CR Hauck","year":"1997","journal-title":"FEBS Lett"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.1365-2958.1997.4191776.x","article-title":"The <italic>Neisseria<\/italic> type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells.","volume":"24","author":"L Lin","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1365-2958.2006.05429.x","article-title":"<italic>Neisseria gonorrhoeae<\/italic> requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells.","volume":"62","author":"TA Hagen","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/35024105","article-title":"Pilus retraction powers bacterial twitching motility.","volume":"407","author":"AJ Merz","year":"2000","journal-title":"Nature"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physiolgenomics.2000.3.2.93","article-title":"A novel, sensitive detection system for high-density microarrays using dendrimer technology.","volume":"3","author":"RL Stears","year":"2000","journal-title":"Physiol Genomics"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2144\/04363RR02","article-title":"Development of a microarray assay that measures hybridization stoichiometry in moles.","volume":"36","author":"RJ Rouse","year":"2004","journal-title":"Biotechniques"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1084\/jem.188.5.941","article-title":"Gonococcal Invasion of Epithelial Cells Driven by P.IA, a Bacterial Ion Channel with GTP Binding Properties.","volume":"188","author":"JPM van Putten","year":"1998","journal-title":"J Exp Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0140-6736(86)92441-4","article-title":"Meningococcal bacteraemia in febrile contacts of patients with meningococcal disease.","volume":"2","author":"RA Wall","year":"1986","journal-title":"Lancet"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1128\/JB.185.20.6032-6041.2003","article-title":"The iron-responsive regulator fur is transcriptionally autoregulated and not essential in <italic>Neisseria meningitidis<\/italic>.","volume":"185","author":"I Delany","year":"2003","journal-title":"J Bacteriol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1128\/JB.182.23.6783-6790.2000","article-title":"Degradation of heme in gram-negative bacteria: the product of the <italic>hemO<\/italic> gene of Neisseriae is a heme oxygenase.","volume":"182","author":"W Zhu","year":"2000","journal-title":"J Bacteriol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/iai.29.3.886-891.1980","article-title":"Iron-controlled infection with <italic>Neisseria meningitidis<\/italic> in mice.","volume":"29","author":"BE Holbein","year":"1980","journal-title":"Infect Immun"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/jb.85.6.1274-1279.1963","article-title":"<italic>Neisseria Gonorrhoeae<\/italic>. I. Virulence Genetically Linked To Clonal Variation.","volume":"85","author":"DS Kellogg Jr","year":"1963","journal-title":"J Bacteriol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-6445(03)00055-X","article-title":"Bacterial iron homeostasis.","volume":"27","author":"SC Andrews","year":"2003","journal-title":"FEMS Microbiology Reviews"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1099\/mic.0.27925-0","article-title":"Complete and variant forms of the &apos;gonococcal genetic island&apos; in <italic>Neisseria meningitidis<\/italic>.","volume":"151","author":"LA Snyder","year":"2005","journal-title":"Microbiology"},{"key":"ref96","article-title":"BioArray Software Environment: A Platform for Comprehensive Management and Analysis of Microarray Data.","volume":"3","author":"LaoH Saal","year":"2002","journal-title":"Genome Biology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/bioinformatics\/17.6.509","article-title":"A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes.","volume":"17","author":"P Baldi","year":"2001","journal-title":"Bioinformatics"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1099\/00222615-38-6-442","article-title":"Alteration of transfer ribonucleic acid of <italic>Neisseria meningitidis<\/italic> during growth in the presence of human transferrin.","volume":"38","author":"DA Ala'Aldeen","year":"1993","journal-title":"J Med Microbiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/JB.181.9.2895-2901.1999","article-title":"Ferric Enterobactin Binding and Utilization by <italic>Neisseria gonorrhoeae<\/italic>.","volume":"181","author":"SDB Carson","year":"1999","journal-title":"J Bacteriol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T01:20:12Z","timestamp":1633310412000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005198"}},"subtitle":[],"editor":[{"given":"Debbie","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,8]]},"references-count":100,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005198","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,8]]}}}