{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:52:59Z","timestamp":1790499179037,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T00:00:00Z","timestamp":1241049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005394","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T16:29:04Z","timestamp":1241022544000},"page":"e5394","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Polymorphism Located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 Haplotype Confer Susceptibility to CNS Hypersomnias (Essential Hypersomnia)"],"prefix":"10.1371","volume":"4","author":[{"given":"Taku","family":"Miyagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minae","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ng.231","article-title":"Variant between CPT1B and CHKB associated with susceptibility to narcolepsy.","volume":"40","author":"T Miyagawa","year":"2008","journal-title":"Nat Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1399-0039.1984.tb02144.x","article-title":"HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive.","volume":"24","author":"T Juji","year":"1984","journal-title":"Tissue Antigens"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.","volume":"68","author":"E Mignot","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(84)92742-9","article-title":"Genetic markers in narcolepsy.","volume":"2","author":"N Langdon","year":"1984","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/sleep\/30.10.1274","article-title":"Idiopathic hypersomnia: a study of 77 cases.","volume":"30","author":"KN Anderson","year":"2007","journal-title":"Sleep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.","volume":"59","author":"E Mignot","year":"2002","journal-title":"Arch Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/sleep\/29.11.1429","article-title":"A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness.","volume":"29","author":"SC Hong","year":"2006","journal-title":"Sleep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/sleep\/9.1.133","article-title":"HLA-DR2 and Dw2 in narcolepsy and in other disorders of excessive somnolence without cataplexy.","volume":"9","author":"Y Honda","year":"1986","journal-title":"Sleep"},{"key":"ref9","first-page":"341","article-title":"Genetic aspects of narcolepsy","author":"Y Honda","year":"1998"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1440-1819.2005.01357.x","article-title":"Difference in the characteristics of subjective and objective sleepiness between narcolepsy and essential hypersomnia.","volume":"59","author":"Y Komada","year":"2005","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.","volume":"244","author":"JD McGarry","year":"1997","journal-title":"Eur J Biochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neures.2006.02.003","article-title":"Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice.","volume":"55","author":"G Yoshida","year":"2006","journal-title":"Neurosci Res"},{"key":"ref13","article-title":"Reduced Carnitine Level Causes Death from Hypoglycemia: Possible Involvement of Suppression of Hypothalamic Orexin Expression During Weaning Period.","author":"M Kuwajima","year":"2007","journal-title":"Endocr J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.","volume":"98","author":"RM Chemelli","year":"1999","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.","volume":"30","author":"J Hara","year":"2001","journal-title":"Neuron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1174","article-title":"Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.","volume":"34","author":"M Tafti","year":"2003","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.plipres.2003.12.001","article-title":"Structure and function of choline kinase isoforms in mammalian cells.","volume":"43","author":"C Aoyama","year":"2004","journal-title":"Prog Lipid Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0005-2760(97)00112-4","article-title":"CTP:phosphocholine cytidylyltransferase.","volume":"1348","author":"C Kent","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20032100","article-title":"Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain.","volume":"200","author":"J Zweigner","year":"2004","journal-title":"J Exp Med"},{"key":"ref20","first-page":"CD000269","article-title":"Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.","author":"M Fioravanti","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/neu.1997.14.161","article-title":"Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release.","volume":"14","author":"CE Dixon","year":"1997","journal-title":"J Neurotrauma"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","article-title":"Pharmacological aspects of human and canine narcolepsy.","volume":"52","author":"S Nishino","year":"1997","journal-title":"Prog Neurobiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T15:12:45Z","timestamp":1558278765000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005394"}},"subtitle":[],"editor":[{"given":"David C.","family":"Rubinsztein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,30]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005394","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,30]]}}}