{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:53:33Z","timestamp":1792036413508,"version":"4.4.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005428","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T18:07:55Z","timestamp":1241114875000},"page":"e5428","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Altering Chemosensitivity by Modulating Translation Elongation"],"prefix":"10.1371","volume":"4","author":[{"given":"Francis","family":"Robert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svea","family":"Rawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","article-title":"The consensus coding sequences of human breast and colorectal cancers.","volume":"314","author":"T Sjoblom","year":"2006","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.1145720","article-title":"The genomic landscapes of human breast and colorectal cancers.","volume":"318","author":"LD Wood","year":"2007","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00109-001-0293-3","article-title":"Apoptosis and chemoresistance in transgenic cancer models.","volume":"80","author":"CA Schmitt","year":"2002","journal-title":"J Mol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0804821105","article-title":"mTORC1 promotes survival through translational control of Mcl-1.","volume":"105","author":"JR Mills","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature02369","article-title":"Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.","volume":"428","author":"HG Wendel","year":"2004","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7639","DOI":"10.1158\/0008-5472.CAN-06-0419","article-title":"Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.","volume":"66","author":"HG Wendel","year":"2006","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR.","volume":"18","author":"N Hay","year":"2004","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0021-9258(19)75938-9","article-title":"Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.","volume":"262","author":"R Duncan","year":"1987","journal-title":"J Biol Chem"},{"key":"ref9","first-page":"245","article-title":"Regulation of ribosome recruitment in eukaryotes.","author":"B Raught","year":"2000"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(85)90200-4","article-title":"Insertion mutagenesis to increase secondary structure within the 5\u2032 noncoding region of a eukaryotic mRNA reduces translational efficiency.","volume":"40","author":"J Pelletier","year":"1985","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1093\/nar\/gkl558","article-title":"Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.","volume":"34","author":"O Larsson","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1038\/sj.onc.1207545","article-title":"eIF-4E expression and its role in malignancies and metastases.","volume":"23","author":"A De Benedetti","year":"2004","journal-title":"Oncogene"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1371\/journal.pone.0000242","article-title":"Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.","volume":"2","author":"Y Mamane","year":"2007","journal-title":"PLoS ONE"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1097-2765(03)00395-2","article-title":"Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.","volume":"12","author":"VK Rajasekhar","year":"2003","journal-title":"Mol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1158\/0008-5472.CAN-07-5635","article-title":"Targeting the eukaryotic translation initiation factor 4E for cancer therapy.","volume":"68","author":"JR Graff","year":"2008","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature02369","article-title":"Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.","volume":"428","author":"H-G Wendel","year":"2004","journal-title":"Nature"},{"key":"ref17","first-page":"1","article-title":"Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.","volume":"118","author":"ME Bordeleau","year":"2008","journal-title":"J Clin Inv"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/345544a0","article-title":"Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5\u2032 cap.","volume":"345","author":"A Lazaris-Karatzas","year":"1990","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nm1042","article-title":"The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.","volume":"10","author":"D Ruggero","year":"2004","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0804821105","article-title":"mTORC1 promotes survival through translational control of Mcl-1.","volume":"105","author":"JR Mills","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/cncr.22398","article-title":"Phase I\/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy.","volume":"109","author":"A Quintas-Cardama","year":"2007","journal-title":"Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.2174\/138161207782360555","article-title":"Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison.","volume":"13","author":"C Le Tourneau","year":"2007","journal-title":"Curr Pharm Des"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/np030304+","article-title":"Antitumor activity of bruceantin: an old drug with new promise.","volume":"67","author":"M Cuendet","year":"2004","journal-title":"J Nat Prod"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/nar\/gkh235","article-title":"Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen.","volume":"32","author":"O Novac","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref25","article-title":"Therapeutic Opportunities in Translation.","author":"J Pelletier","year":"2007"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.","volume":"12","author":"JA Diehl","year":"1998","journal-title":"Genes Dev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1128\/MCB.4.11.2486","article-title":"Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.","volume":"4","author":"SR Hann","year":"1984","journal-title":"Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/bj3560473","article-title":"Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis.","volume":"356","author":"KM Schubert","year":"2001","journal-title":"Biochem J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.cell.2005.03.037","article-title":"ARF-BP1\/Mule is a critical mediator of the ARF tumor suppressor.","volume":"121","author":"D Chen","year":"2005","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1101\/gad.1093903","article-title":"Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.","volume":"17","author":"D Nijhawan","year":"2003","journal-title":"Genes Dev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1158\/1535-7163.MCT-05-0164","article-title":"Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells.","volume":"5","author":"R Tang","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1038\/sj.onc.1205543","article-title":"Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127\u2013189 of c-myc.","volume":"21","author":"D Alarcon-Vargas","year":"2002","journal-title":"Oncogene"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1432-1033.1977.tb11256.x","article-title":"Inhibition of translation in eukaryotic systems by harringtonine.","volume":"72","author":"M Fresno","year":"1977","journal-title":"Eur J Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0167-4781(92)90484-H","article-title":"Selective inhibition of the polypeptide chain elongation in eukaryotic cells.","volume":"1129","author":"RM Tujebajeva","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0026-895X(25)11141-3","article-title":"Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis.","volume":"12","author":"LL Liao","year":"1976","journal-title":"Mol Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0005-2787(81)90168-4","article-title":"Mechanism of eukaryotic protein synthesis inhibition by brusatol.","volume":"654","author":"W Willingham Jr","year":"1981","journal-title":"Biochim Biophys Acta"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0026-895X(25)10662-7","article-title":"Harringtonine, an inhibitor of initiation of protein biosynthesis.","volume":"11","author":"MT Huang","year":"1975","journal-title":"Mol Pharmacol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0092-8674(94)90462-6","article-title":"Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.","volume":"78","author":"KL Rock","year":"1994","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1074\/jbc.M610643200","article-title":"Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.","volume":"282","author":"KW Adams","year":"2007","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.","volume":"22","author":"T Chou","year":"1984","journal-title":"Adv Enzyme Regul"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.","volume":"3","author":"S Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"ref42","first-page":"245","article-title":"Augmentation of epirubicin cytotoxicity by cycloheximide.","volume":"91","author":"S Furusawa","year":"1996","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ccr.2006.01.012","article-title":"Using small molecules to overcome drug resistance induced by a viral oncogene.","volume":"9","author":"I Smukste","year":"2006","journal-title":"Cancer Cell"},{"key":"ref44","first-page":"701","article-title":"In vitro modulation of cisplatin cytotoxicity by sparsomycin inhibition of protein synthesis.","volume":"78","author":"Z Zylicz","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00001813-199402000-00006","article-title":"Concentration and sequence dependent synergism of ethyldeshydroxy-sparsomycin in combination with antitumor agents.","volume":"5","author":"HP Hofs","year":"1994","journal-title":"Anticancer Drugs"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000237992","article-title":"Therapeutic activity of pretazettine on Ehrlich ascites carcinoma: adjuvant effect on standard drugs in ABC regimen.","volume":"27","author":"E Furusawa","year":"1981","journal-title":"Chemotherapy"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0145-2126(91)90112-7","article-title":"Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture.","volume":"15","author":"Y Kano","year":"1991","journal-title":"Leuk Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"20593","DOI":"10.1074\/jbc.M211010200","article-title":"Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.","volume":"278","author":"NK Sah","year":"2003","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1124\/mol.57.3.529","article-title":"Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity.","volume":"57","author":"Budihardjo II","year":"2000","journal-title":"Mol Pharmacol"},{"key":"ref50","first-page":"1193","article-title":"Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells.","volume":"49","author":"T Sakai","year":"1989","journal-title":"Cancer Res"},{"key":"ref51","first-page":"1135","article-title":"Selective protection by anguidine of normal versus transformed cells against 1-beta-D-arabinofuranosylcytosine and Adriamycin.","volume":"43","author":"R Hromas","year":"1983","journal-title":"Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/0006-2952(92)90697-H","article-title":"Abrogation of adriamycin toxicity in vivo by cycloheximide.","volume":"43","author":"NS Thakkar","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1124\/jpet.106.110007","article-title":"Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels.","volume":"319","author":"J Bai","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref54","first-page":"1403","article-title":"Clinical pharmacology of homoharringtonine.","volume":"70","author":"N Savaraj","year":"1986","journal-title":"Cancer Treat Rep"},{"key":"ref55","first-page":"139","article-title":"Pharmacokinetics of homoharringtonine in dogs.","volume":"21","author":"K Lu","year":"1988","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00873128","article-title":"Phase II clinical and pharmacological study of didemnin B in patients with metastatic breast cancer.","volume":"10","author":"JA Benvenuto","year":"1992","journal-title":"Invest New Drugs"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/bdd.466","article-title":"Fate of tritiated didemnin B in mice: excretion and tissue concentrations after an intraperitoneal dose.","volume":"26","author":"VR Beasley","year":"2005","journal-title":"Biopharm Drug Dispos"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00257747","article-title":"Clinical pharmacology of bruceantin by radioimmunoassay.","volume":"9","author":"KL Fong","year":"1982","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.leu.2403784","article-title":"Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.","volume":"19","author":"S Wuilleme-Toumi","year":"2005","journal-title":"Leukemia"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/sj.onc.1210679","article-title":"A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.","volume":"27","author":"K Podar","year":"2008","journal-title":"Oncogene"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.semcancer.2006.07.014","article-title":"The c-Myc target gene network.","volume":"16","author":"CV Dang","year":"2006","journal-title":"Semin Cancer Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cellsig.2007.10.018","article-title":"GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy.","volume":"20","author":"F Takahashi-Yanaga","year":"2008","journal-title":"Cell Signal"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/jcb.21519","article-title":"Cyclin degradation for cancer therapy and chemoprevention.","volume":"102","author":"SJ Freemantle","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/j.1460-2075.1994.tb06307.x","article-title":"Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.","volume":"13","author":"R Merino","year":"1994","journal-title":"Embo J"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/cs0800587","article-title":"Measurement of tumour protein synthesis in vivo in human colorectal and breast cancer and its variability in separate biopsies from the same tumour.","volume":"80","author":"SD Heys","year":"1991","journal-title":"Clin Sci (Lond)"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.1073096","article-title":"Cancer. Addiction to oncogenes\u2013the Achilles heal of cancer.","volume":"297","author":"IB Weinstein","year":"2002","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T01:39:15Z","timestamp":1739065155000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005428"}},"subtitle":[],"editor":[{"given":"Grzegorz","family":"Kudla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,5,1]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005428","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,1]]}}}