{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:39:44Z","timestamp":1774867184795,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T00:00:00Z","timestamp":1242172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005530","type":"journal-article","created":{"date-parts":[[2009,5,12]],"date-time":"2009-05-12T21:32:30Z","timestamp":1242163950000},"page":"e5530","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metabolites of Cerebellar Neurons and Hippocampal Neurons Play Opposite Roles in Pathogenesis of Alzheimer's Disease"],"prefix":"10.1371","volume":"4","author":[{"given":"Jing","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingquan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0092-8674(94)90048-5","article-title":"Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.","volume":"77","author":"WD Snider","year":"1994","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.","volume":"260","author":"LF Lin","year":"1993","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/156720506775697061","article-title":"Dissecting the diverse actions of pro- and mature neurotrophins.","volume":"3","author":"BL Hempstead","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1001\/jama.1997.03550160083043","article-title":"Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society.","volume":"278","author":"GW Small","year":"1997","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nn940","article-title":"Alzheimer's disease: treatments in discovery and development.","volume":"5","author":"M Citron","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0028-3932(95)00151-4","article-title":"Analysis of the episodic memory deficit in early Alzheimer's disease: evidence from the doors and people test.","volume":"34","author":"JD Greene","year":"1996","journal-title":"Neuropsychologia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/archneur.1993.00540040036010","article-title":"Explicit memory in Alzheimer's, Huntington's, and Parkinson's diseases.","volume":"50","author":"B Pillon","year":"1993","journal-title":"Arch Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1126\/science.282.5391.1075","article-title":"Genetic classification of primary neurodegenerative disease.","volume":"282","author":"J Hardy","year":"1998","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0165-0173(97)00023-4","article-title":"Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts.","volume":"25","author":"P Giannakopoulos","year":"1997","journal-title":"Brain Res Brain Res Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(94)92338-8","article-title":"Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease.","volume":"344","author":"MJ West","year":"1994","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0006-8993(98)00759-8","article-title":"Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease.","volume":"805","author":"M Bobinski","year":"1998","journal-title":"Brain Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-4580(94)90139-2","article-title":"Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites.","volume":"15","author":"YT Li","year":"1994","journal-title":"Neurobiol Aging"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.","volume":"416","author":"DM Walsh","year":"2002","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1096\/fj.01-0987fje","article-title":"Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein.","volume":"17","author":"HJ Kim","year":"2003","journal-title":"Faseb J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neurobiolaging.2004.06.013","article-title":"Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.","volume":"26","author":"A Caccamo","year":"2005","journal-title":"Neurobiol Aging"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0166-2236(93)90008-A","article-title":"Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease.","volume":"16","author":"DJ Selkoe","year":"1993","journal-title":"Trends Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0197-4580(98)00033-5","article-title":"Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.","volume":"19","author":"TC Saido","year":"1998","journal-title":"Neurobiol Aging"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra040223","article-title":"Alzheimer's disease.","volume":"351","author":"JL Cummings","year":"2004","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.","volume":"106","author":"M Shibata","year":"2000","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1471-4159.2004.02385.x","article-title":"Clearing amyloid through the blood-brain barrier.","volume":"89","author":"BV Zlokovic","year":"2004","journal-title":"J Neurochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0896-6273(01)00475-5","article-title":"Clearing the brain's amyloid cobwebs.","volume":"32","author":"DJ Selkoe","year":"2001","journal-title":"Neuron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2008.06.109","article-title":"Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice.","volume":"594","author":"HY Qu","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.4049\/jimmunol.181.9.6503","article-title":"IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.","volume":"181","author":"E Shimizu","year":"2008","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"11120","DOI":"10.1523\/JNEUROSCI.2860-04.2004","article-title":"Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.","volume":"24","author":"L Zhao","year":"2004","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1139\/y03-027","article-title":"Development of the brain: a vital role for cerebrospinal fluid.","volume":"81","author":"JA Miyan","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-8454-6-3","article-title":"Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats.","volume":"6","author":"J Du","year":"2009","journal-title":"Cerebrospinal Fluid Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1471-4159.1981.tb05297.x","article-title":"Uptake of 36Cl and 22Na by the choroid plexus-cerebrospinal fluid system: evidence for active chloride transport by the choroidal epithelium.","volume":"37","author":"QR Smith","year":"1981","journal-title":"J Neurochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nn0901-887","article-title":"The \u2018Arctic\u2019 APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.","volume":"4","author":"C Nilsberth","year":"2001","journal-title":"Nat Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/77399","article-title":"Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.","volume":"6","author":"N Iwata","year":"2000","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/35046031","article-title":"A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.","volume":"408","author":"G Chen","year":"2000","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0197-4580(00)00107-X","article-title":"Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.","volume":"21","author":"C Janus","year":"2000","journal-title":"Neurobiol Aging"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.","volume":"408","author":"C Janus","year":"2000","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02244409","article-title":"Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice.","volume":"100","author":"N Venable","year":"1990","journal-title":"Psychopharmacology (Berl)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0197-4580(02)00098-2","article-title":"Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.","volume":"24","author":"PH Kelly","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.","volume":"316","author":"ED Roberson","year":"2007","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T01:15:33Z","timestamp":1558314933000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005530"}},"subtitle":[],"editor":[{"given":"Colin","family":"Combs","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,5,13]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005530","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,13]]}}}