{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:29:06Z","timestamp":1781234946075,"version":"3.54.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2009,5,18]],"date-time":"2009-05-18T00:00:00Z","timestamp":1242604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0005576","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T18:44:09Z","timestamp":1242413049000},"page":"e5576","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["GluK2-Mediated Excitability within the Superficial Layers of the Entorhinal Cortex"],"prefix":"10.1371","volume":"4","author":[{"given":"Prateep S.","family":"Beed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Salmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neuro.2005.02.004","article-title":"Kainate receptors and mossy fiber LTP.","volume":"25","author":"ZA Borlotto","year":"2005","journal-title":"Neurotoxicology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.coph.2005.08.004","article-title":"Kainate receptor physiology.","volume":"6","author":"J Lerma","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00441-006-0265-6","article-title":"Kainate receptors.","volume":"326","author":"P Pinheiro","year":"2006","journal-title":"Cell Tissue Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1523\/JNEUROSCI.23-30-09761.2003","article-title":"Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro.","volume":"23","author":"MO Cunningham","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1523\/JNEUROSCI.5054-05.2006","article-title":"Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness.","volume":"26","author":"MO Cunningham","year":"2006","journal-title":"Journal of Neuroscience"},{"key":"ref6","first-page":"127","article-title":"Oscillatory activity in entorhinal neurons and circuits - Mechanisms and function.","volume":"911","author":"CT Dickson","year":"2000","journal-title":"Parahippocampal Region"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.2004.077388","article-title":"Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.","volume":"562","author":"A Fisahn","year":"2005","journal-title":"Journal of Physiology-London"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.3954-06.2007","article-title":"Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations.","volume":"27","author":"JR Huxter","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-5793(92)80753-4","article-title":"High-Affinity Kainate and Domoate Receptors in Rat-Brain.","volume":"307","author":"H Lomeli","year":"1992","journal-title":"Febs Letters"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1523\/JNEUROSCI.13-12-05009.1993","article-title":"The Differential Expression of 16 Nmda and Non-Nmda Receptor Subunits in the Rat Spinal-Cord and in Periaqueductal Gray.","volume":"13","author":"TR Tolle","year":"1993","journal-title":"Journal of Neuroscience"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/351742a0","article-title":"Cloning of A Putative High-Affinity Kainate Receptor Expressed Predominantly in Hippocampal CA3 Cells.","volume":"351","author":"P Werner","year":"1991","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1523\/JNEUROSCI.13-08-03582.1993","article-title":"A Complex Mosaic of High-Affinity Kainate Receptors in Rat-Brain.","volume":"13","author":"W Wisden","year":"1993","journal-title":"Journal of Neuroscience"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0301-0082(03)00122-9","article-title":"Kainate receptors and synaptic transmission.","volume":"70","author":"JE Huettner","year":"2003","journal-title":"Progress in Neurobiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/33408","article-title":"Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice.","volume":"392","author":"C Mulle","year":"1998","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0896-6273(00)00126-4","article-title":"Subunit composition of kainate receptors in hippocampal interneurons.","volume":"28","author":"C Mulle","year":"2000","journal-title":"Neuron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0166-2236(00)01659-3","article-title":"Kainate, a double agent that generates seizures: two decades of progress.","volume":"23","author":"Y Ben-Ari","year":"2000","journal-title":"Trends Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0306-4522(00)00225-6","article-title":"Laminar differences in recurrent excitatory transmission in the rat entorhinal cortex in vitro.","volume":"99","author":"A Dhillon","year":"2000","journal-title":"Neuroscience"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0306-4522(96)00494-0","article-title":"Morphological and electrophysiological characterization of layer III cells of the medial entorhinal cortex of the rat.","volume":"77","author":"T Gloveli","year":"1997","journal-title":"Neuroscience"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0306-4522(97)00263-7","article-title":"Electroresponsiveness of medial entorhinal cortex layer III neurons in vitro.","volume":"81","author":"CT Dickson","year":"1997","journal-title":"Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1152\/jn.1997.78.6.3444","article-title":"Frequency-dependent information flow from the entorhinal cortex to the hippocampus.","volume":"78","author":"T Gloveli","year":"1997","journal-title":"J Neurophysiol"},{"key":"ref21","first-page":"217","article-title":"RNA editing of brain glutamate receptor channels: mechanism and physiology.","volume":"26","author":"PH Seeburg","year":"1998","journal-title":"Brain Research Reviews"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0959-4388(03)00062-X","article-title":"Regulation of ion channel\/neurotransmitter receptor function by RNA editing.","volume":"13","author":"PH Seeburg","year":"2003","journal-title":"Current Opinion in Neurobiology"},{"key":"ref23","first-page":"R370","article-title":"RNA editing in the brain.","volume":"358","author":"R Sprengel","year":"1998","journal-title":"Naunyn-Schmiedebergs Archives of Pharmacology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1523\/JNEUROSCI.23-16-06660.2003","article-title":"Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons.","volume":"23","author":"M Eder","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/40645","article-title":"Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons.","volume":"388","author":"PE Castillo","year":"1997","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/40639","article-title":"The synaptic activation of kainate receptors.","volume":"388","author":"M Vignes","year":"1997","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2990.1993.tb00458.x","article-title":"Selective Excitotoxic Pathology in the Rat Hippocampus.","volume":"19","author":"LE Jarrard","year":"1993","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/exnr.1997.6625","article-title":"The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.","volume":"148","author":"DG MacGregor","year":"1997","journal-title":"Experimental Neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2005.01012.x","article-title":"Physiological changes in chronic epileptic rats are prominent in superficial layers of the medial entorhinal area.","volume":"46","author":"EA Tolner","year":"2005","journal-title":"Epilepsia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.nbd.2007.01.009","article-title":"Synaptic responses in superficial layers of medical entorhinal cortex from rats with kainate-induced epilepsy.","volume":"26","author":"EA Tolner","year":"2007","journal-title":"Neurobiology of Disease"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1523\/JNEUROSCI.22-17-07434.2002","article-title":"AMPA receptors and kainate receptors encode different features of afferent activity.","volume":"22","author":"M Frerking","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0165-6147(98)01286-3","article-title":"Kainate receptors: subunits, synaptic localization and function.","volume":"20","author":"R Chittajallu","year":"1999","journal-title":"Trends in Pharmacological Sciences"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1523\/JNEUROSCI.14-09-05525.1994","article-title":"Kainate Receptor Gene-Expression in the Developing Rat-Brain.","volume":"14","author":"S Bahn","year":"1994","journal-title":"Journal of Neuroscience"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.270.5242.1677","article-title":"Early-Onset Epilepsy and Postnatal Lethality Associated with An Editing-Deficient Glur-B Allele in Mice.","volume":"270","author":"R Brusa","year":"1995","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/35017558","article-title":"Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2.","volume":"406","author":"M Higuchi","year":"2000","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1523\/JNEUROSCI.19-20-08757.1999","article-title":"Generation and analysis of GluR5(Q636R) kainate receptor mutant mice.","volume":"19","author":"A Sailer","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0896-6273(01)00192-1","article-title":"The role of RNA editing of kainate receptors in synaptic plasticity and seizures.","volume":"29","author":"B Vissel","year":"2001","journal-title":"Neuron"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00004647-199607000-00004","article-title":"RNA editing of glutamate receptor subunits GluR2, GluR5, and GluR6 in transient cerebral ischemia in the rat.","volume":"16","author":"W Paschen","year":"1996","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1097\/00001756-199807130-00013","article-title":"Editing status at the Q\/R site of the GluR2 and GluR6 glutamate receptor subunits in the surgically excised hippocampus of patients with refractory epilepsy.","volume":"9","author":"EV Grigorenko","year":"1998","journal-title":"Neuroreport"},{"key":"ref40","first-page":"107","article-title":"RNA editing of the glutamate receptor subunits GluR2, GluR5 and GluR6 in nervous tissue from epileptic patients.","volume":"12","author":"G Kortenbruck","year":"2000","journal-title":"European Journal of Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/nbdi.2001.0394","article-title":"RNA editing at the Q\/R site for the glutamate receptor subunits GluR2, GluR5, and GluR6 in hippocampus and temporal cortex from epileptic patients.","volume":"8","author":"G Kortenbruck","year":"2001","journal-title":"Neurobiology of Disease"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-2002-34830","article-title":"Postoperative investigations in epilepsy surgery: Molecularbiological analyses.","volume":"32","author":"U Musshoff","year":"2002","journal-title":"Klinische Neurophysiologie"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1073\/pnas.0306731101","article-title":"Astrocyte-mediated activation of neuronal kainate receptors.","volume":"101","author":"QS Liu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref44","first-page":"128","article-title":"Comparison of kainate receptor-mediated EPSCS in superficial layer neurons of the rat medial entorhinal cortex.","volume":"46","author":"PJ West","year":"2005","journal-title":"Epilepsia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroscience.2007.02.035","article-title":"Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.","volume":"146","author":"PJ West","year":"2007","journal-title":"Neuroscience"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0163-7258(00)00038-3","article-title":"Neuronal fast oscillations as a target site for psychoactive drugs.","volume":"86","author":"MA Whittington","year":"2000","journal-title":"Pharmacology & Therapeutics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1086\/521275","article-title":"A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.","volume":"81","author":"MM Motazacker","year":"2007","journal-title":"American Journal of Human Genetics"}],"updated-by":[{"DOI":"10.1371\/annotation\/40012908-73d7-4bfc-8731-d24ec701dca4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0005576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:52:27Z","timestamp":1558313547000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0005576"}},"subtitle":[],"editor":[{"given":"Liset Menendez","family":"de la Prida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,5,18]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,5,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0005576","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/40012908-73d7-4bfc-8731-d24ec701dca4","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,18]]}}}