{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:09:49Z","timestamp":1790104189312,"version":"4.0.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T00:00:00Z","timestamp":1248998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006454","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T17:47:18Z","timestamp":1248976038000},"page":"e6454","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Loss of GATA4 and GATA6 Expression Specifies Ovarian Cancer Histological Subtypes and Precedes Neoplastic Transformation of Ovarian Surface Epithelia"],"prefix":"10.1371","volume":"4","author":[{"given":"Kathy Qi","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Caslini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callinice D.","family":"Capo-chichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres J.","family":"Klein-Szanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Godwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Xi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/modpathol.3800306","article-title":"Origins and molecular pathology of ovarian cancer.","volume":"18","author":"DA Bell","year":"2005","journal-title":"Mod Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jcb.240590928","article-title":"Pathology of ovarian cancer precursors.","volume":"23","author":"RE Scully","year":"1995","journal-title":"J Cell Biochem Suppl"},{"key":"ref3","first-page":"159","article-title":"Early form of ovarian cancer originating in inclusion cysts. A case report.","volume":"45","author":"Y Aoki","year":"2000","journal-title":"J Reprod Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2559.2001.01042.x","article-title":"Precursor lesions of ovarian epithelial malignancy.","volume":"38","author":"KM Feeley","year":"2001","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ygyno.2008.03.016","article-title":"Whence epithelial ovarian carcinoma?","volume":"109","author":"J Boyd","year":"2008","journal-title":"Gynecol Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/gyno.1998.5275","article-title":"The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?","volume":"72","author":"L Dubeau","year":"1999","journal-title":"Gynecol Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube.","volume":"211","author":"Y Lee","year":"2007","journal-title":"J Pathol"},{"key":"ref8","first-page":"791","article-title":"Surface epithelial tumors of the ovary.","author":"JD Seidman","year":"2002"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJM198502213120804","article-title":"Common epithelial cancer of the ovary (2).","volume":"312","author":"GS Richardson","year":"1985","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer.","volume":"100","author":"D Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0002-9378(13)70310-7","article-title":"The p53 tumor suppressor gene frequently is altered in gynecologic cancers.","volume":"70","author":"A Berchuck","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"ref12","first-page":"103","article-title":"Oncogenes and tumor-suppressor genes.","author":"J Boyd","year":"2000"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1535-6108(04)00002-9","article-title":"Focus on epithelial ovarian cancer.","volume":"5","author":"RF Ozols","year":"2004","journal-title":"Cancer Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-78771-3_1","article-title":"Differentiation and tumor progression.","volume":"139","author":"NE Fusenig","year":"1995","journal-title":"Recent Results Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1073\/pnas.92.3.647","article-title":"Differentiation and cancer: the conditional autonomy of phenotype.","volume":"92","author":"RG Lynch","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0092-8674(80)90373-6","article-title":"Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes.","volume":"22","author":"JG Rheinwald","year":"1980","journal-title":"Cell"},{"key":"ref17","first-page":"4967","article-title":"Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis.","volume":"63","author":"CD Capo-chichi","year":"2003","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1038\/sj.onc.1209533","article-title":"Histone modifications silence the GATA transcription factor genes in ovarian cancer.","volume":"25","author":"C Caslini","year":"2006","journal-title":"Oncogene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"38949","DOI":"10.1074\/jbc.R000029200","article-title":"The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.","volume":"275","author":"JD Molkentin","year":"2000","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.","volume":"11","author":"CT Kuo","year":"1997","journal-title":"Genes Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/dbio.1996.0165","article-title":"GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm.","volume":"177","author":"EE Morrisey","year":"1996","journal-title":"Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ydbio.2005.07.037","article-title":"Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.","volume":"286","author":"CD Capo-Chichi","year":"2005","journal-title":"Dev Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1242\/dev.126.4.723","article-title":"The transcription factor GATA6 is essential for early extraembryonic development.","volume":"126","author":"M Koutsourakis","year":"1999","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1002\/dvdy.21703","article-title":"Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis.","volume":"237","author":"KQ Cai","year":"2008","journal-title":"Dev Dyn"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1101\/gad.12.22.3579","article-title":"GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.","volume":"12","author":"EE Morrisey","year":"1998","journal-title":"Genes Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.canlet.2005.10.039","article-title":"Involvement of GATA-4\/-5 transcription factors in ovarian carcinogenesis.","volume":"241","author":"K Wakana","year":"2006","journal-title":"Cancer Lett"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19949","DOI":"10.1074\/jbc.M001331200","article-title":"The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm.","volume":"275","author":"EE Morrisey","year":"2000","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1038\/sj.onc.1202649","article-title":"Disabled-2 inactivation is an early step in ovarian tumorigenicity.","volume":"18","author":"Z Fazili","year":"1999","journal-title":"Oncogene"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"13114","DOI":"10.1074\/jbc.M611356200","article-title":"Disabled-2 is an epithelial surface positioning gene.","volume":"282","author":"DH Yang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/dbio.2002.0810","article-title":"Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.","volume":"251","author":"DH Yang","year":"2002","journal-title":"Dev Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/emboj\/21.7.1555","article-title":"Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport.","volume":"21","author":"SM Morris","year":"2002","journal-title":"EMBO J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2353\/ajpath.2006.060036","article-title":"Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53 null background.","volume":"169","author":"DH Yang","year":"2006","journal-title":"Am J Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1093\/emboj\/cdf487","article-title":"Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor.","volume":"21","author":"SK Mishra","year":"2002","journal-title":"EMBO J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1038\/sj.onc.1203853","article-title":"Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells.","volume":"19","author":"Z Sheng","year":"2000","journal-title":"Oncogene;"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/cncr.10497","article-title":"Molecular events associated with dysplastic morphologic transformation and initiation of ovarian tumorigenicity.","volume":"94","author":"DH Yang","year":"2002","journal-title":"Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ygyno.2006.03.053","article-title":"Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations.","volume":"103","author":"KQ Cai","year":"2006","journal-title":"Gyn Oncology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1093\/jnci\/88.24.1810","article-title":"Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies.","volume":"88","author":"H Salazar","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0090-8258(92)90075-T","article-title":"Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma.","volume":"47","author":"LE Puls","year":"1992","journal-title":"Gynecol Oncol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code.","volume":"293","author":"T Jenuwein","year":"2001","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/sj.emboj.7600013","article-title":"Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.","volume":"23","author":"V Mutskov","year":"2004","journal-title":"EMBO J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01080","article-title":"Active genes are tri-methylated at K4 of histone H3.","volume":"419","author":"H Santos-Rosa","year":"2002","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ncb1076","article-title":"Histone H3 lysine 4 methylation patterns in higher eukaryotic genes.","volume":"6","author":"R Schneider","year":"2004","journal-title":"Nat Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.","volume":"410","author":"M Lachner","year":"2001","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T03:09:47Z","timestamp":1633748987000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006454"}},"subtitle":[],"editor":[{"given":"Sudhansu Kumar","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,7,31]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2009,7,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006454","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10405956.11231054","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,31]]}}}