{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:14:32Z","timestamp":1791850472334,"version":"4.3.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006510","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T22:34:11Z","timestamp":1249338851000},"page":"e6510","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":334,"title":["Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal"],"prefix":"10.1371","volume":"4","author":[{"given":"Catherine","family":"Dostert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Guarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackeline F.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Menu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubry","family":"Tardivel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario-Luca","family":"Suva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Stehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Kopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Stamenkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampietro","family":"Corradin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurg","family":"Tschopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.mib.2008.06.005","article-title":"Interactions of the malaria parasite and its mammalian host.","volume":"11","author":"O Silvie","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1474-4422(05)70247-7","article-title":"Pathogenesis, clinical features, and neurological outcome of cerebral malaria.","volume":"4","author":"R Idro","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.pt.2008.08.008","article-title":"Recent insights into humoral and cellular immune responses against malaria.","volume":"24","author":"JG Beeson","year":"2008","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.f.205","article-title":"Immunity to malaria: more questions than answers.","volume":"9","author":"J Langhorne","year":"2008","journal-title":"Nat Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri1686","article-title":"Immunological processes in malaria pathogenesis.","volume":"5","author":"L Schofield","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.tim.2007.04.003","article-title":"Manipulation of host innate immune responses by the malaria parasite.","volume":"15","author":"C Coban","year":"2007","journal-title":"Trends Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molbiopara.2007.11.005","article-title":"Haemozoin formation.","volume":"157","author":"TJ Egan","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1473-3099(07)70238-4","article-title":"Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator.","volume":"7","author":"T Hanscheid","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.4049\/jimmunol.172.5.3101","article-title":"Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection.","volume":"172","author":"M Jaramillo","year":"2004","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.20041836","article-title":"Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.","volume":"201","author":"C Coban","year":"2005","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/intimm\/dxl123","article-title":"Pathological role of Toll-like receptor signaling in cerebral malaria.","volume":"19","author":"C Coban","year":"2007","journal-title":"Int Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.2353\/ajpath.2007.060889","article-title":"Murine cerebral malaria development is independent of toll-like receptor signaling.","volume":"170","author":"D Togbe","year":"2007","journal-title":"Am J Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0608745104","article-title":"Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.","volume":"104","author":"P Parroche","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.","volume":"10","author":"F Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.coi.2008.06.001","article-title":"NOD-like receptors (NLRs): bona fide intracellular microbial sensors.","volume":"20","author":"MH Shaw","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.chom.2008.08.007","article-title":"The caspase-1 inflammasome: a pilot of innate immune responses.","volume":"4","author":"HB Yu","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref17","article-title":"NLRC4\/IPAF: a CARD carrying member of the NLR family.","author":"FS Sutterwala","year":"2008","journal-title":"Clin Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1021\/cr078274t","article-title":"Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design.","volume":"108","author":"I Weissbuch","year":"2008","journal-title":"Chem Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.160.3.1122","article-title":"Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds.","volume":"160","author":"DE Macfarlane","year":"1998","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.","volume":"9","author":"V Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"F Martinon","year":"2006","journal-title":"Nature"},{"key":"ref22","first-page":"57","article-title":"Mouse models for erythrocytic-stage malaria.","volume":"72","author":"LA Sanni","year":"2002","journal-title":"Methods Mol Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.","volume":"430","author":"S Mariathasan","year":"2004","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.","volume":"267","author":"K Kuida","year":"1995","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.","volume":"9","author":"O Adachi","year":"1998","journal-title":"Immunity"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.159.5.2452","article-title":"Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.","volume":"159","author":"M Labow","year":"1997","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.","volume":"320","author":"C Dostert","year":"2008","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1128\/MCB.26.3.735-742.2006","article-title":"Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.","volume":"26","author":"A Didierlaurent","year":"2006","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T06:31:24Z","timestamp":1685082684000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006510"}},"subtitle":[],"editor":[{"given":"Derya","family":"Unutmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006510","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}