{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:18:15Z","timestamp":1789978695466,"version":"4.0.1"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2009,8,14]],"date-time":"2009-08-14T00:00:00Z","timestamp":1250208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006643","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T21:54:53Z","timestamp":1250200493000},"page":"e6643","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Phosphodiesterase Inhibition Increases CREB Phosphorylation and Restores Orientation Selectivity in a Model of Fetal Alcohol Spectrum Disorders"],"prefix":"10.1371","volume":"4","author":[{"given":"Thomas E.","family":"Krahe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre E.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ntt.2003.07.012","article-title":"Fetal Alcohol Syndrome prevention: annual and cumulative cost savings.","volume":"25","author":"MG Klug","year":"2003","journal-title":"Neurotoxicol Teratol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/09297040600646854","article-title":"Neurobehavioral functioning in children with fetal alcohol spectrum disorder.","volume":"12","author":"C Rasmussen","year":"2006","journal-title":"Child Neuropsychol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/09297049608402249","article-title":"Global-local processing in children prenatally exposed to alcohol.","volume":"2","author":"SN Mattson","year":"1996","journal-title":"Child Neuropsychol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0028-3932(95)00096-8","article-title":"Spatial locations gone awry: Object and spatial memory deficits in children with fetal alcohol syndrome.","volume":"34","author":"A Uecker","year":"1996","journal-title":"Neuropsychologia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1530-0277.2002.tb02533.x","article-title":"Auditory and visual sustained attention in adolescents prenatally exposed to alcohol.","volume":"26","author":"CD Coles","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1530-0277.1995.tb01564.x","article-title":"Autistic behaviors in offspring of mothers abusing alcohol and other drugs: a series of case reports.","volume":"19","author":"SR Harris","year":"1995","journal-title":"Alcohol Clin Exp Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00221-005-0339-9","article-title":"Prenatal alcohol exposure (PAE) reduces the size of the forepaw representation in forepaw barrel subfield (FBS) cortex in neonatal rats: relationship between periphery and central representation.","volume":"172","author":"CP Margret","year":"2006","journal-title":"Exp Brain Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1523\/JNEUROSCI.23-31-10002.2003","article-title":"Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferrets.","volume":"23","author":"AE Medina","year":"2003","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/jn.00714.2004","article-title":"Early Alcohol Exposure Induces Persistent Alteration of Cortical Columnar Organization and Reduced Orientation Selectivity in the Visual Cortex.","volume":"93","author":"AE Medina","year":"2005","journal-title":"J Neurophysiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1523\/JNEUROSCI.19-24-10993.1999","article-title":"Effect of enriched environment rearing on impairments in cortical excitability and plasticity after prenatal alcohol exposure.","volume":"19","author":"V Rema","year":"1999","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.devbrainres.2005.01.003","article-title":"effects of prenatal alcohol exposure on the development of the vibrissal somatosensory cortical barrel network.","volume":"155","author":"TA Powrozec","year":"2005","journal-title":"Brain Res Dev Brain Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.274.5290.1133","article-title":"Synaptic activity and the constuction of cortical circuits.","volume":"274","author":"LC Katz","year":"1996","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.neuro.31.060407.125533","article-title":"Mechanisms underlying development of visual maps and receptive fields.","volume":"31","author":"AD Huberman","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuron.2007.10.011","article-title":"Vision and Cortical map development.","volume":"56","author":"LE White","year":"2007","journal-title":"Neuron"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1098\/rstb.2002.1228","article-title":"Expression mechanisms underlying long-term potentiation: a postsynaptic view.","volume":"358","author":"R Nicoll","year":"2003","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1523\/JNEUROSCI.22-06-02237.2002","article-title":"cAMP\/Ca2+ response element-binding protein function is essential for ocular dominance plasticity.","volume":"22","author":"AF Mower","year":"2002","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1126\/science.2443978","article-title":"Blockade of \u201cNMDA\u201d receptors disrupts experience-dependent plasticity of kitten striate cortex.","volume":"238","author":"A Kleinschmidt","year":"1987","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.282.5393.1504","article-title":"Local GABA circuit control of experience-dependent plasticity in developing visual cortex.","volume":"282","author":"TK Hensch","year":"1998","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0092-8674(94)90394-8","article-title":"CREB: a mediator of long-term memory from mollusks to mammals.","volume":"79","author":"DA Frank","year":"1994","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1126\/science.1091032","article-title":"Specific GABAA circuits for visual cortical plasticity.","volume":"303","author":"M Fagiolini","year":"2004","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tins.2007.03.012","article-title":"NMDA and AMPA receptors: old channels, new tricks.","volume":"30","author":"VR Rao","year":"2007","journal-title":"Trends Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuroscience.2005.10.060","article-title":"Effect of prenatal exposure to ethanol on glutamate and GABA immunoreactivity in macaque somatosensory and motor cortices: critical timing of exposure.","volume":"138","author":"MW Miller","year":"2006","journal-title":"Neuroscience"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.2467382","article-title":"Ethanol inhibits NMDA-activated ion current in hippocampal neurons.","volume":"243","author":"DM Lovinger","year":"1989","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0006-8993(99)01480-8","article-title":"Postnatal ethanol exposure blunts upregulation of GABAA receptor currents in Purkinje neurons.","volume":"832","author":"SH Hsiao","year":"1999","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1126\/science.6328654","article-title":"Decreased neuronal inhibition in vitro after long-term administration of ethanol.","volume":"224","author":"D Durand","year":"1984","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1530-0277.2000.tb02043.x","article-title":"A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels.","volume":"24","author":"ET Costa","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1530-0277.1996.tb05272.x","article-title":"Effects of prenatal ethanol exposure on voltage-dependent calcium entry into neonatal whole brain-dissociated neurons.","volume":"20","author":"YH Lee","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1073\/pnas.0607037104","article-title":"Purkinje cell dysfunction and alteration of long-term synaptic plasticity in fetal alcohol syndrome.","volume":"104","author":"L Servais","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0092-8674(00)81816-4","article-title":"CREB phosphorylation and dephosphorylation: A Ca++ and stimulus duration dependent switch for hippocampal gene expression.","volume":"87","author":"H Bito","year":"1996","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(02)00655-4","article-title":"CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.","volume":"34","author":"JM Kornhauser","year":"2002","journal-title":"Neuron"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s000180050314","article-title":"CREB: a message to remember.","volume":"55","author":"R Lamprecht","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-6273(02)00664-5","article-title":"Dynamic multiphosphorylation passwords for activity-dependent gene expression.","volume":"34","author":"K Deisseroth","year":"2002","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","article-title":"Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity.","volume":"16","author":"K Deisseroth","year":"1996","journal-title":"Neuron"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0896-6273(00)80395-5","article-title":"CREB: a major mediator of neuronal neurotrophin responses.","volume":"19","author":"S Finkbeiner","year":"1997","journal-title":"Neuron"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1523\/JNEUROSCI.4177-05.2006","article-title":"Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure.","volume":"26","author":"AE Medina","year":"2006","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1073\/pnas.95.25.15020","article-title":"Rolipram, a type IV-specific phophodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.","volume":"95","author":"M Barad","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.npp.1300813","article-title":"Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear.","volume":"31","author":"B Monti","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use.","volume":"58","author":"AT Bender","year":"2006","journal-title":"Pharmacol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.2174\/138161206777698855","article-title":"Improving memory: a role for phosphodiesterases.","volume":"12","author":"A Blokland","year":"2006","journal-title":"Curr Pharm Des"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jnr.21447","article-title":"Neocortical plasticity deficits in fetal alcohol spectrum disorders: Lessons from Barrel and Visual Cortex.","volume":"86","author":"AE Medina","year":"2008","journal-title":"J Neurosci Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(01)00171-3","article-title":"Translating developmental time across mammalian species.","volume":"105","author":"B Clancy","year":"2001","journal-title":"Neuroscience"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/j.1460-9568.1994.tb00565.x","article-title":"Ultrastructural evidence for synaptic interactions between thalamocortical axons and subplate neurons.","volume":"6","author":"K Herrmann","year":"1994","journal-title":"Eur J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1523\/JNEUROSCI.16-20-06443.1996","article-title":"Development of orientation preference maps in ferret primary visual cortex.","volume":"16","author":"B Chapman","year":"1996","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1073\/pnas.95.5.2621","article-title":"Unequal representation of cardinal and oblique contours in ferret visual cortex.","volume":"95","author":"DM Coppola","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/353429a0","article-title":"Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patterns.","volume":"353","author":"T Bonhoeffer","year":"1991","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1096-9861(19971027)387:3<358::AID-CNE3>3.0.CO;2-#","article-title":"Optically imaged maps of orientation preference in primary visual cortex of cats and ferrets.","volume":"387","author":"SC Rao","year":"1997","journal-title":"J Comp Neurol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03190120","article-title":"Pharmacokinetics of vinpocetine and its main metabolite apovincaminic acid before and after the chronic oral administration of vinpocetine to humans.","volume":"15","author":"P Miskolczi","year":"1990","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(01)00381-6","article-title":"The CRE\/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons.","volume":"31","author":"TA Pham","year":"2001","journal-title":"Neuron"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1523\/JNEUROSCI.13-12-05251.1993","article-title":"Development of orientation selectivity in ferret visual cortex and effects of deprivation.","volume":"13","author":"B Chapman","year":"1993","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/35082568","article-title":"The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex.","volume":"411","author":"LE White","year":"2001","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1113\/jphysiol.1959.sp006308","article-title":"Receptive fields of single neurones in the cat&apos;s striate cortex.","volume":"148","author":"DH Hubel","year":"1959","journal-title":"J Physiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1113\/jphysiol.1962.sp006837","article-title":"Receptive fields, binocular interaction and functional architecture in the cat&apos;s visual cortex.","volume":"160","author":"DH Hubel","year":"1962","journal-title":"J Physiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.1963.sp007079","article-title":"Shape and arrangement of columns in cat&apos;s striate cortex.","volume":"165","author":"DH Hubel","year":"1963","journal-title":"J Physiol"},{"key":"ref54","article-title":"The organization of behavior.","author":"DO Hebb","year":"1949"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1073\/pnas.70.4.997","article-title":"A physiological mechanism for Hebb&apos;s postulate of learning.","volume":"70","author":"GS Stent","year":"1973","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/321519a0","article-title":"NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.","volume":"321","author":"AB MacDermott","year":"1986","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.","volume":"309","author":"ML Mayer","year":"1984","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/307462a0","article-title":"Magnesium gates glutamate-activated channels in mouse central neurons.","volume":"307","author":"L Nowak","year":"1984","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1523\/JNEUROSCI.10-03-00909.1990","article-title":"Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist.","volume":"10","author":"MF Bear","year":"1990","journal-title":"J Neurosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1073\/pnas.93.24.13453","article-title":"A synaptic basis for memory storage in the cerebral cortex.","volume":"93","author":"MF Bear","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0092-8674(05)80029-7","article-title":"Molecular machines integrate coincident synaptic signals.","volume":"72","author":"HR Bourne","year":"1993","journal-title":"Cell"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1523\/JNEUROSCI.21-12-04299.2001","article-title":"Suppression of cortical NMDA receptor function prevents development of orientation selectivity in the primary visual cortex.","volume":"21","author":"AS Ramoa","year":"2001","journal-title":"J Neurosci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"16797","DOI":"10.1073\/pnas.0806159105","article-title":"Delayed plasticity of inhibitory neurons in developing visual cortex.","volume":"105","author":"SP Gandhi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.1091031","article-title":"Columnar architecture sculpted by GABA circuits in developing cat visual cortex.","volume":"303","author":"TK Hensch","year":"2004","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1152\/jn.2001.85.4.1436","article-title":"Responses of neurons in neonatal cortex and thalamus to patterned visual stimulation through the naturally closed lids.","volume":"85","author":"K Krug","year":"2001","journal-title":"J Neurophysiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cercor\/6.2.178","article-title":"Development of horizontal projections in layer 2\/3 of ferret visual cortex.","volume":"6","author":"JC Durack","year":"1996","journal-title":"Cerebral Cortex"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"r818","DOI":"10.1016\/S0960-9822(02)01318-0","article-title":"The role of activity in development of the visual system.","volume":"12","author":"F Sengpiel","year":"2002","journal-title":"Curr Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0741-8329(92)90007-W","article-title":"Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring.","volume":"9","author":"DD Savage","year":"1992","journal-title":"Alcohol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1471-4159.2005.03294.x","article-title":"Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder.","volume":"94","author":"R Galindo","year":"2005","journal-title":"J Neurochem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"26985","DOI":"10.1074\/jbc.274.38.26985","article-title":"Ethanol-induced translocation of cAMP-dependent protein kinase to the nucleus.","volume":"274","author":"A Constatinescu","year":"1999","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1471-4159.1998.70010224.x","article-title":"Chronic ethanol adminstration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat cerebellum.","volume":"70","author":"X Yang","year":"1988","journal-title":"J Neurochem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1530-0277.1998.tb03664.x","article-title":"Chronic ethanol exposure impairs phosphorylation of CREB and CRE-binding activity in rat striatum.","volume":"22","author":"X Yang","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0022-3565(24)38827-5","article-title":"Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat cortex.","volume":"296","author":"SC Pandey","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0006-8993(98)00891-9","article-title":"Development of GABAA receptors on medial septum\/diagonal band (MS\/DB) neurons after postnatal ethanol exposure.","volume":"810","author":"SH Hsiao","year":"1998","journal-title":"Brain Res"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-3806(02)00470-4","article-title":"Effects of early postnatal ethanol intubation on GABAergic synaptic proteins.","volume":"138","author":"SH Hsiao","year":"2002","journal-title":"Brain Res Dev Brain Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1523\/JNEUROSCI.19-16-06965.1999","article-title":"The critical period for ocular dominance plasticity in the ferret&apos;s visual cortex.","volume":"19","author":"NP Issa","year":"1999","journal-title":"J Neurosci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1177\/0091270005279363","article-title":"Acute and chronic effects of vinpocetine on cerebral hemodynamics and neuropsychological performance in multi-infarct patients.","volume":"45","author":"V Kemeny","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"14826","DOI":"10.1073\/pnas.94.26.14826","article-title":"Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation.","volume":"94","author":"D Malonek","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.272.5261.551","article-title":"Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping.","volume":"272","author":"D Malonek","year":"1996","journal-title":"Science"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1126\/science.286.5444.1555","article-title":"Increased cortical oxidadtive metabolism due to sensory stimulation: implications for functional brain imaging.","volume":"286","author":"I Vanzetta","year":"1999","journal-title":"Science"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1079220","article-title":"Single-neuron activity and tissue oxygenation in the cerebral cortex.","volume":"299","author":"JK Thompson","year":"2003","journal-title":"Science"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1073\/pnas.95.7.4002","article-title":"The distribution of oriented contours in the real world.","volume":"95","author":"DM Coppola","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0896-6273(03)00332-5","article-title":"Dynamics of orientation selectivity in the primary visual cortex and the importance of cortical inhibition.","volume":"38","author":"R Shapley","year":"2003","journal-title":"Neuron"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.1523\/JNEUROSCI.15-08-05448.1995","article-title":"An emergent model of orientation selectivity in cat visual cortical simple cells.","volume":"15","author":"DC Somers","year":"1995","journal-title":"J Neurosci"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0387-7604(01)00351-5","article-title":"Neurobiology of rett syndrome: a genetic disorder of synapse development.","volume":"23","author":"MV Johnston","year":"2001","journal-title":"Brain Dev"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1090-3798(03)00039-4","article-title":"Brain plasticity in paediatric neurology.","volume":"7","author":"MV Johnston","year":"2003","journal-title":"Eur J Paediatr Neurol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0387-7604(03)00102-5","article-title":"Clinical disorders of brain plasticity.","volume":"26","author":"MV Johnston","year":"2004","journal-title":"Brain Dev"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2005.02.012","article-title":"Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome.","volume":"49","author":"RJ Siarey","year":"2005","journal-title":"Neuropharmacology"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrd1061","article-title":"Targeting the CREB pathway for memory enhancers.","volume":"2","author":"T Tully","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.2174\/138161205774370799","article-title":"Phosphodiesterase inhibitors for cognitive enhancement.","volume":"11","author":"GM Rose","year":"2005","journal-title":"Curr Pharm Des"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuron.2005.09.016","article-title":"Protein synthesis independent plasticity mediates rapid and precise recovery of deprived eye responses.","volume":"48","author":"TE Krahe","year":"2005","journal-title":"Neuron"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1109\/TSMC.1973.4309314","article-title":"Textural features for image classification.","volume":"3","author":"RM Haralick","year":"1973","journal-title":"IEEE Trans on system, man and cybernetics"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1046\/j.1460-9568.1998.00274.x","article-title":"The layout of orientation selectivity and ocular dominance domains in area 17 of strabismic cats.","volume":"10","author":"S Lowel","year":"1998","journal-title":"Eur J Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T18:56:36Z","timestamp":1739300196000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006643"}},"subtitle":[],"editor":[{"given":"Kenji","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,8,14]]},"references-count":93,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006643","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,14]]}}}