{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:08:40Z","timestamp":1775304520388,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006870","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T18:30:36Z","timestamp":1251743436000},"page":"e6870","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Caspase-12 and the Inflammatory Response to Yersinia pestis"],"prefix":"10.1371","volume":"4","author":[{"given":"Bart","family":"Ferwerda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B. B.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike C.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost","family":"Hopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubacar","family":"Maiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amagana","family":"Dolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ogobara","family":"Doumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modibo","family":"Daou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A. B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi A.","family":"Tissingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans A. G.","family":"Reubsaet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sauerwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W. M.","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 J. A. M.","family":"van der Ven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20041142","article-title":"The protein structures that shape caspase activity, specificity, activation and inhibition.","volume":"384","author":"P Fuentes-Prior","year":"2004","journal-title":"Biochem J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation.","volume":"14","author":"F Martinon","year":"2007","journal-title":"Cell Death Differ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.4049\/jimmunol.177.7.4239","article-title":"The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis.","volume":"177","author":"A Nadiri","year":"2006","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0006-291X(02)00289-9","article-title":"Human caspase 12 has acquired deletrious mutations.","volume":"293","author":"H Fischer","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/humu.9448","article-title":"Population distribution of the functional caspase-12 allele.","volume":"27","author":"K Kachapati","year":"2006","journal-title":"Hum.Mutat"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/503116","article-title":"Spread of an inactive form of caspase-12 in humans is due to recent positive selection.","volume":"78","author":"Y Xue","year":"2006","journal-title":"Am J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.","volume":"403","author":"T Nakagawa","year":"2000","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2478(02)00228-6","article-title":"Recognition of pathogen-associated molecular patterns by TLR family.","volume":"85","author":"S Akira","year":"2003","journal-title":"Immunol.Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Innate immunity.","volume":"343","author":"R Medzhitov","year":"2000","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(95)90490-5","article-title":"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.","volume":"80","author":"P Li","year":"1995","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature02451","article-title":"Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.","volume":"429","author":"M Saleh","year":"2004","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/sj.cdd.4402026","article-title":"The inflammatory caspases: guardians against infections and sepsis.","volume":"14","author":"AM Scott","year":"2007","journal-title":"Cell Death.Differ"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis.","volume":"420","author":"J Cohen","year":"2002","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis.","volume":"348","author":"RS Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature04656","article-title":"Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.","volume":"440","author":"M Saleh","year":"2006","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1371\/journal.pbio.0040052","article-title":"Gene losses during human origins.","volume":"4","author":"X Wang","year":"2006","journal-title":"PLoS Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.chom.2008.02.004","article-title":"Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity.","volume":"3","author":"PM LeBlanc","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"14043","DOI":"10.1073\/pnas.96.24.14043","article-title":"Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis.","volume":"96","author":"M Achtman","year":"1999","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1078\/1438-4221-00277","article-title":"Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model.","volume":"293","author":"A Sing","year":"2003","journal-title":"Int J Med Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ni1386","article-title":"Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.","volume":"7","author":"SW Montminy","year":"2006","journal-title":"Nat Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/nrm932","article-title":"The Yersinia Ysc-Yop \u2018type III\u2019 weaponry.","volume":"3","author":"GR Cornelis","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"25134","DOI":"10.1074\/jbc.M401245200","article-title":"Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.","volume":"279","author":"P Schotte","year":"2004","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-185X.2007.00024.x","article-title":"Conceptual bases for quantifying the role of the environment on gene evolution: the participation of positive selection and neutral evolution.","volume":"82","author":"A Levasseur","year":"2007","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/molbev\/msn012","article-title":"Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire.","volume":"25","author":"L Eckhart","year":"2008","journal-title":"Mol Biol Evol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.cdd.4400989","article-title":"Alice in caspase land. A phylogenetic analysis of caspases from worm to man.","volume":"9","author":"M Lamkanfi","year":"2002","journal-title":"Cell Death Differ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/00365520601076074","article-title":"HCV infection clearance with functional or non-functional caspase-12.","volume":"42","author":"TR O'Brien","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4269\/ajtmh.2005.72.243","article-title":"Difference in susceptibility to malaria between two sympatric ethnic groups in Mali.","volume":"72","author":"A Dolo","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref28","first-page":"305","article-title":"NOD2 3020insC mutation and the pathogenesis of Crohn&apos;s disease: impaired IL-1beta production points to a loss-of-function phenotype.","volume":"63","author":"MG Netea","year":"2005","journal-title":"Neth J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1128\/IAI.69.3.1477-1482.2001","article-title":"Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.","volume":"69","author":"M Hirschfeld","year":"2001","journal-title":"Infect Immun"},{"key":"ref30","first-page":"215","article-title":"Development of a sensitive ELISA for the quantification of human tumour necrosis factor-alpha using 4 polyclonal antibodies.","volume":"16","author":"N Grebenchtchikov","year":"2005","journal-title":"Eur Cytokine Netw"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T04:53:45Z","timestamp":1558500825000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006870"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,9,1]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006870","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,1]]}}}