{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:13:16Z","timestamp":1761765196155},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006885","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T22:43:15Z","timestamp":1251931395000},"page":"e6885","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["PrP Expression, PrPSc Accumulation and Innervation of Splenic Compartments in Sheep Experimentally Infected with Scrapie"],"prefix":"10.1371","volume":"4","author":[{"given":"Randi","family":"S\u00f8rby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Austb\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles McL.","family":"Press","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grethe","family":"Skretting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Landsverk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arild","family":"Espenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0092-8674(00)81163-0","article-title":"Prion protein biology.","volume":"93","author":"SB Prusiner","year":"1998","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/infdis\/146.5.657","article-title":"Natural infection of Suffolk sheep with scrapie virus.","volume":"146","author":"WJ Hadlow","year":"1982","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1099\/0022-1317-83-2-479","article-title":"Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep.","volume":"83","author":"R Heggebo","year":"2002","journal-title":"J Gen Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1354\/vp.42-3-258","article-title":"Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes.","volume":"42","author":"C Ersdal","year":"2005","journal-title":"Vet Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0168-1702(89)90040-3","article-title":"Pathogenesis of scrapie in mice after intragastric infection.","volume":"12","author":"RH Kimberlin","year":"1989","journal-title":"Virus Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/37981","article-title":"PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain.","volume":"389","author":"T Blattler","year":"1997","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1099\/0022-1317-81-11-2813","article-title":"PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion.","volume":"81","author":"M Glatzel","year":"2000","journal-title":"J Gen Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1099\/vir.0.82008-0","article-title":"Lymphoid follicles of the ileal Peyer's patch of lambs express low levels of PrP, as demonstrated by quantitative real-time RT-PCR on microdissected tissue compartments, in situ hybridization and immunohistochemistry.","volume":"87","author":"L Austbo","year":"2006","journal-title":"J Gen Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1099\/vir.0.82791-0","article-title":"Increased PrP mRNA expression in lymphoid follicles of the ileal Peyer's patch of sheep experimentally exposed to the scrapie agent.","volume":"88","author":"L Austbo","year":"2007","journal-title":"J Gen Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/014107688207500809","article-title":"Pathogenesis of mouse scrapie: patterns of agent replication in different parts of the CNS following intraperitoneal infection.","volume":"75","author":"RH Kimberlin","year":"1982","journal-title":"J R Soc Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1099\/0022-1317-77-8-1925","article-title":"Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie.","volume":"77 (Pt 8)","author":"M Beekes","year":"1996","journal-title":"J Gen Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(01)00331-2","article-title":"Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion.","volume":"31","author":"M Glatzel","year":"2001","journal-title":"Neuron"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/path.1711680412","article-title":"PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice.","volume":"168","author":"PA McBride","year":"1992","journal-title":"J Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jnr.490180107","article-title":"Noradrenergic sympathetic innervation of the spleen: I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp.","volume":"18","author":"DL Felten","year":"1987","journal-title":"J Neurosci Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/jcpa.2002.0625","article-title":"Detection of PrPSc in lymphoid tissues of lambs experimentally exposed to the scrapie agent.","volume":"128","author":"R Heggebo","year":"2003","journal-title":"J Comp Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"755s","DOI":"10.4049\/jimmunol.135.2.755","article-title":"Noradrenergic and peptidergic innervation of lymphoid tissue.","volume":"135","author":"DL Felten","year":"1985","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0889-1591(88)90031-1","article-title":"Sympathetic noradrenergic innervation of immune organs.","volume":"2","author":"DL Felten","year":"1988","journal-title":"Brain Behav Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0889-1591(91)90005-U","article-title":"Substance P innervation of spleen in rats: nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen.","volume":"5","author":"D Lorton","year":"1991","journal-title":"Brain Behav Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0168-1702(89)90039-7","article-title":"The role of the spleen in the neuroinvasion of scrapie in mice.","volume":"12","author":"RH Kimberlin","year":"1989","journal-title":"Virus Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/j.1460-2075.1996.tb00467.x","article-title":"Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.","volume":"15","author":"M Fischer","year":"1996","journal-title":"EMBO J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/35052063","article-title":"Prions: health scare and biological challenge.","volume":"2","author":"A Aguzzi","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature02072","article-title":"Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.","volume":"425","author":"M Prinz","year":"2003","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.0308413101","article-title":"Cells release prions in association with exosomes.","volume":"101","author":"B Fevrier","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0167-5699(00)01696-0","article-title":"Follicular dendritic cells in TSE pathogenesis.","volume":"21","author":"ME Bruce","year":"2000","journal-title":"Immunol Today"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI200113155","article-title":"Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie.","volume":"108","author":"P Aucouturier","year":"2001","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jneuroim.2007.05.006","article-title":"Assessing the involvement of migratory dendritic cells in the transfer of the scrapie agent from the immune to peripheral nervous systems.","volume":"187","author":"CR Raymond","year":"2007","journal-title":"J Neuroimmunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1304","DOI":"10.1371\/journal.pone.0001304","article-title":"Scrapie-specific pathology of sheep lymphoid tissues.","volume":"2","author":"G McGovern","year":"2007","journal-title":"PLoS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/15264","article-title":"Scrapie replication in lymphoid tissues depends on prion protein- expressing follicular dendritic cells.","volume":"5","author":"KL Brown","year":"1999","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1086\/512085","article-title":"Peripheral circulation of the prion infectious agent in transgenic mice expressing the ovine prion protein gene in neurons only.","volume":"195","author":"C Crozet","year":"2007","journal-title":"J Infect Dis"},{"key":"ref30","first-page":"111","article-title":"Evidence of differences between Peyer's patches and germinal centers.","volume":"186","author":"JD Reynolds","year":"1985","journal-title":"Adv Exp Med Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1006\/bbrc.2000.3035","article-title":"Analysis of prion protein mRNA by in situ hybridization in brain and placenta of sheep.","volume":"273","author":"A Kubosaki","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.0305-1846.2001.00343.x","article-title":"In situ hybridization analysis of PrP mRNA in human CNS tissues.","volume":"27","author":"NF McLennan","year":"2001","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1128\/jvi.76.5.2434-2439.2002","article-title":"PrP expression and replication by Schwann cells: implications in prion spreading.","volume":"76","author":"J Follet","year":"2002","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T15:46:57Z","timestamp":1685116017000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006885"}},"subtitle":[],"editor":[{"given":"Matthew","family":"Baylis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,9,3]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006885","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,3]]}}}