{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:58:43Z","timestamp":1791194323271,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006904","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T21:50:36Z","timestamp":1252014636000},"page":"e6904","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intracellular Calcium Deficits in Drosophila Cholinergic Neurons Expressing Wild Type or FAD-Mutant Presenilin"],"prefix":"10.1371","volume":"4","author":[{"given":"Kinga","family":"Michno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.","family":"Campussano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"van de Hoef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle L.","family":"Boulianne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial alzheimer&apos;s disease.","volume":"349(6311)","author":"A Goate","year":"1991","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial alzheimer&apos;s disease.","volume":"375(6534)","author":"R Sherrington","year":"1995","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial alzheimer&apos;s disease in kindreds with missense mutations in a gene on chromosome 1 related to the alzheimer&apos;s disease type 3 gene.","volume":"376(6543)","author":"EI Rogaev","year":"1995","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/8438","article-title":"Transgenic mice with alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.","volume":"5(5)","author":"DH Chui","year":"1999","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/nbdi.2001.0473","article-title":"A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.","volume":"9(2)","author":"Z Amtul","year":"2002","journal-title":"Neurobiol Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.20083","article-title":"A novel presenilin 1 mutation associated with pick&apos;s disease but not beta-amyloid plaques.","volume":"55(5)","author":"B Dermaut","year":"2004","journal-title":"Ann Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1212\/WNL.55.10.1577","article-title":"Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation.","volume":"55(10)","author":"G Raux","year":"2000","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/nbdi.1998.0176","article-title":"Calcium responses in fibroblasts from asymptomatic members of alzheimer&apos;s disease families.","volume":"5(1)","author":"R Etcheberrigaray","year":"1998","journal-title":"Neurobiol Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(02)02970-0","article-title":"Ca(2+) stores and capacitative ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial alzheimer&apos;s disease presenilin-1 mutation.","volume":"949(1\u20132)","author":"IF Smith","year":"2002","journal-title":"Brain Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ceca.2006.03.002","article-title":"Presenilin mutations linked to familial alzheimer&apos;s disease reduce endoplasmic reticulum and golgi apparatus calcium levels.","volume":"39(6)","author":"G Zatti","year":"2006","journal-title":"Cell Calcium"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/nbdi.2001.0382","article-title":"Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling.","volume":"8(3)","author":"MA Leissring","year":"2001","journal-title":"Neurobiol Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1083\/jcb.149.4.793","article-title":"Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.","volume":"149(4)","author":"MA Leissring","year":"2000","journal-title":"J Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.nbd.2003.11.002","article-title":"The presenilin 2 M239I mutation associated with familial alzheimer&apos;s disease reduces Ca2+ release from intracellular stores.","volume":"15(2)","author":"G Zatti","year":"2004","journal-title":"Neurobiol Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ceca.2008.03.004","article-title":"The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction.","volume":"44(5)","author":"V Hayrapetyan","year":"2008","journal-title":"Cell Calcium"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biocel.2007.06.023","article-title":"The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity.","volume":"40(1)","author":"V Rybalchenko","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1196\/annals.1379.025","article-title":"Enhanced ryanodine-mediated calcium release in mutant PS1-expressing alzheimer&apos;s mouse models.","volume":"1097","author":"GE Stutzmann","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2008.04.015","article-title":"Mechanism of Ca2+ disruption in alzheimer&apos;s disease by presenilin regulation of InsP3 receptor channel gating.","volume":"58(6)","author":"KH Cheung","year":"2008","journal-title":"Neuron"},{"key":"ref18","first-page":"1051","article-title":"Calmodulin-binding domains in alzheimer&apos;s disease proteins: Extending the calcium hypothesis.","volume":"320(4)","author":"DH O'Day","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"14965","DOI":"10.1074\/jbc.M200897200","article-title":"Molecular cloning and characterization of CALP\/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.","volume":"277(17)","author":"Y Morohashi","year":"2002","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.yexcr.2004.07.020","article-title":"Calcium binding sequences in calmyrin regulates interaction with presenilin-2.","volume":"300(2)","author":"J Zhu","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1074\/jbc.M311040200","article-title":"Calmodulin binding to the fas death domain. regulation by fas activation.","volume":"279(7)","author":"EY Ahn","year":"2004","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","article-title":"Presenilins form ER Ca2+ leak channels, a function disrupted by familial alzheimer&apos;s disease-linked mutations.","volume":"126(5)","author":"H Tu","year":"2006","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00001756-199703030-00041","article-title":"Cloning and characterization of the drosophila presenilin homologue.","volume":"8(4)","author":"GL Boulianne","year":"1997","journal-title":"Neuroreport"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","article-title":"The genome sequence of drosophila melanogaster.","volume":"287(5461)","author":"MD Adams","year":"2000","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/19096","article-title":"Neurogenic phenotypes and altered notch processing in drosophila presenilin mutants.","volume":"398(6727)","author":"Y Ye","year":"1999","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/19091","article-title":"Presenilin is required for activity and nuclear access of notch in drosophila.","volume":"398(6727)","author":"G Struhl","year":"1999","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/dneu.20532","article-title":"Presynaptic plasticity and associative learning are impaired in a drosophila presenilin null mutant.","volume":"67(12)","author":"D Knight","year":"2007","journal-title":"Dev Neurobiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1096\/fj.06-6380com","article-title":"A role for presenilin in post-stress regulation: Effects of presenilin mutations on Ca2+ currents in drosophila.","volume":"21(10)","author":"Y Lu","year":"2007","journal-title":"FASEB J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/genetics\/165.3.1255","article-title":"Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system.","volume":"165(3)","author":"B Wang","year":"2003","journal-title":"Genetics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/genetics\/149.1.217","article-title":"Genes expressed in the ring gland, the major endocrine organ of drosophila melanogaster.","volume":"149(1)","author":"PD Harvie","year":"1998","journal-title":"Genetics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1073\/pnas.93.6.2420","article-title":"Spontaneous avoidance behavior in drosophila null for calmodulin expression.","volume":"93(6)","author":"RG Heiman","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1523\/JNEUROSCI.19-19-08435.1999","article-title":"Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.","volume":"19(19)","author":"Y Guo","year":"1999","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1083\/jcb.146.6.1351","article-title":"Apoptotic activities of wild-type and alzheimer&apos;s disease-related mutant presenilins in drosophila melanogaster.","volume":"146(6)","author":"Y Ye","year":"1999","journal-title":"J Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1567-133X(01)00011-4","article-title":"Drosophila cholinergic neurons and processes visualized with Gal4\/UAS-GFP.","volume":"1(1)","author":"PM Salvaterra","year":"2001","journal-title":"Brain Res Gene Expr Patterns"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/dneu.20527","article-title":"nAChR-mediated calcium responses and plasticity in drosophila kenyon cells.","volume":"67(11)","author":"JM Campusano","year":"2007","journal-title":"Dev Neurobiol"},{"key":"ref36","first-page":"200","article-title":"Primary neuronal cultures from the brains of late stage drosophila pupae.","volume":"(4)(4)","author":"B Sicaeros","year":"2007","journal-title":"J Vis Exp"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0306-4522(89)90399-0","article-title":"Cortical cholinergic fibers in aging and alzheimer&apos;s disease: A morphometric study.","volume":"33(3)","author":"C Geula","year":"1989","journal-title":"Neuroscience"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1085\/jgp.200308982","article-title":"A store-operated calcium channel in drosophila S2 cells.","volume":"123(2)","author":"AV Yeromin","year":"2004","journal-title":"J Gen Physiol"},{"key":"ref39","article-title":"Identifying genes that interact with drosophila presenilin and amyloid precursor protein.","author":"D van de Hoef","year":"2009","journal-title":"Genesis (in press)"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1074\/jbc.R000030200","article-title":"Ca2+-dependent cell signaling through calmodulin-activated protein phosphatase and protein kinases minireview series.","volume":"276(4)","author":"JT Stull","year":"2001","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-001-0111-4","article-title":"Modulation of intracellular calcium-release channels by calmodulin.","volume":"185(1)","author":"DM Balshaw","year":"2002","journal-title":"J Membr Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1073\/pnas.93.6.2420","article-title":"Spontaneous avoidance behavior in drosophila null for calmodulin expression.","volume":"93(6)","author":"RG Heiman","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1074\/jbc.M909882199","article-title":"Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.","volume":"275(19)","author":"E Pack-Chung","year":"2000","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"16649","DOI":"10.1074\/jbc.M512026200","article-title":"The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.","volume":"281(24)","author":"C Cai","year":"2006","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0896-6273(04)00182-5","article-title":"Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.","volume":"42(1)","author":"CA Saura","year":"2004","journal-title":"Neuron"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/jnr.21601","article-title":"Loss of presenilin function causes alzheimer&apos;s disease-like neurodegeneration in the mouse.","volume":"86(7)","author":"Q Chen","year":"2008","journal-title":"J Neurosci Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.cub.2006.04.004","article-title":"Modeling clinically heterogeneous presenilin mutations with transgenic drosophila.","volume":"16(10)","author":"GA Seidner","year":"2006","journal-title":"Curr Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1365-4624.1997.00012.x","article-title":"Human presenilin-1, but not familial alzheimer&apos;s disease (FAD) mutants, facilitate caenorhabditis elegans notch signalling independently of proteolytic processing.","volume":"1(2)","author":"R Baumeister","year":"1997","journal-title":"Genes Funct"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"14940","DOI":"10.1073\/pnas.93.25.14940","article-title":"Assessment of normal and mutant human presenilin function in caenorhabditis elegans.","volume":"93(25)","author":"D Levitan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ceca.2006.03.005","article-title":"Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.","volume":"40(1)","author":"NN Kasri","year":"2006","journal-title":"Cell Calcium"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1083\/jcb.145.6.1277","article-title":"A myristoylated calcium-binding protein that preferentially interacts with the alzheimer&apos;s disease presenilin 2 protein.","volume":"145(6)","author":"SM Stabler","year":"1999","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/2673","article-title":"Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.","volume":"4(10)","author":"JD Buxbaum","year":"1998","journal-title":"Nat Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1093\/emboj\/18.21.5983","article-title":"Ca(2+)-ATPase function is required for intracellular trafficking of the notch receptor in drosophila.","volume":"18(21)","author":"G Periz","year":"1999","journal-title":"EMBO J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"17354","DOI":"10.1074\/jbc.M010238200","article-title":"Calmodulin enhances the stability of the estrogen receptor.","volume":"276(20)","author":"Z Li","year":"2001","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1046\/j.1440-1827.2002.01398.x","article-title":"Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.","volume":"52(9)","author":"I Maezawa","year":"2002","journal-title":"Pathol Int"}],"updated-by":[{"DOI":"10.1371\/annotation\/f8cecc73-06ec-4bba-b07a-a3bc2a08f4c7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T09:56:40Z","timestamp":1633859800000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006904"}},"subtitle":[],"editor":[{"given":"David C.","family":"Rubinsztein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006904","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/f8cecc73-06ec-4bba-b07a-a3bc2a08f4c7","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]}}}