{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:22:12Z","timestamp":1771262532064,"version":"3.50.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007167","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T12:45:08Z","timestamp":1253882708000},"page":"e7167","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Pathogenic Properties of a Novel and Conserved Gene Product, KerV, in Proteobacteria"],"prefix":"10.1371","volume":"4","author":[{"given":"Dingding","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiorgos","family":"Apidianakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura","family":"Boechat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina L.","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyan C.","family":"Goumnerov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence G.","family":"Rahme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1098\/rstb.2000.0607","article-title":"Quorum sensing and the population-dependent control of virulence.","volume":"355","author":"P Williams","year":"2000","journal-title":"Phil Tran Roy Soc London Ser B: Biol Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1073\/pnas.97.16.8815","article-title":"Plants and animals share functionally common bacterial virulence factors.","volume":"97","author":"LG Rahme","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1078\/1438-4221-00103","article-title":"Iron uptake mechanisms and their regulation in pathogenic bacteria.","volume":"291","author":"V Braun","year":"2001","journal-title":"Int J Med Micro"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.phyto.41.052002.095652","article-title":"Quorum sensing in plant-pathogenic bacteria.","volume":"41","author":"SB von Bodman","year":"2003","journal-title":"Ann Rev Phyt"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.chom.2007.10.004","article-title":"Metropolitan microbes: type III secretion in multihost symbionts.","volume":"2","author":"GM Preston","year":"2007","journal-title":"Cell Host & Microbe"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro1818","article-title":"The biology and future prospects of antivirulence therapies.","volume":"6","author":"L Cegelski","year":"2008","journal-title":"Nat Rev Micro"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1046\/j.1365-2958.2000.02056.x","article-title":"Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts.","volume":"37","author":"S Mahajan-Miklos","year":"2000","journal-title":"Mol Micro"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1126\/science.7604262","article-title":"Common virulence factors for bacterial pathogenicity in plants and animals.","volume":"268","author":"LG Rahme","year":"1995","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8789","DOI":"10.1073\/pnas.97.16.8789","article-title":"Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms.","volume":"97","author":"MR Parsek","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1073\/pnas.052704399","article-title":"The human pathogen <italic>Pseudomonas aeruginosa<\/italic> utilizes conserved virulence pathways to infect the social amoeba <italic>Dictyostelium discoideum<\/italic>.","volume":"99","author":"S Pukatzki","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants.","volume":"62","author":"C Hueck","year":"1998","journal-title":"Micro Mol Biol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1126\/science.1070784","article-title":"<italic>Pseudomonas<\/italic>-<italic>Candida<\/italic> interactions: an ecological role for virulence factors.","volume":"296","author":"D Hogan","year":"2002","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13245","DOI":"10.1073\/pnas.94.24.13245","article-title":"Use of model plant hosts to identify <italic>Pseudomonas aeruginosa<\/italic> virulence factors.","volume":"94","author":"LG Rahme","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1073\/pnas.96.5.2408","article-title":"<italic>Pseudomonas aeruginosa<\/italic> killing of <italic>Caenorhabditis elegans<\/italic> used to identify <italic>P. aeruginosa<\/italic> virulence factors.","volume":"96","author":"M-W Tan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1128\/JB.183.4.1466-1471.2001","article-title":"<italic>Drosophila<\/italic> as a model host for <italic>Pseudomonas aeruginosa<\/italic> infection.","volume":"183","author":"DA D'Argenio","year":"2001","journal-title":"J Bact"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/IAI.01181-08","article-title":"<italic>Pseudomonas aeruginosa<\/italic> infection of zebrafish involves both host and pathogen determinants.","volume":"77","author":"A Clatworthy","year":"2009","journal-title":"Infect Immun"},{"key":"ref17","article-title":"<italic>Pseudomonas aeruginosa<\/italic> the opportunist: pathogenesis and disease.","author":"R Fink","year":"1993"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1073\/pnas.0511100103","article-title":"An ordered, nonredundant library of <italic>Pseudomonas aeruginosa<\/italic> strain PA14 transposon insertion mutants.","volume":"103","author":"N Liberati","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nprot.2008.224","article-title":"Modeling <italic>Pseudomonas aeruginosa<\/italic> pathogenesis in plant hosts.","volume":"4","author":"M Starkey","year":"2009","journal-title":"Nat Protocols"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.0409588102","article-title":"Profiling early infection responses: <italic>Pseudomonas aeruginosa<\/italic> eludes host defenses by suppressing antimicrobial peptide gene expression.","volume":"102","author":"Y Apidianakis","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1128\/JB.184.11.3027-3033.2002","article-title":"<italic>Pseudomonas aeruginosa<\/italic> virulence analyzed in a <italic>Dictyostelium discoideum<\/italic> host system.","volume":"184","author":"P Cosson","year":"2002","journal-title":"J Bact"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/IAI.63.4.1278-1285.1995","article-title":"Role of <italic>Pseudomonas aeruginosa<\/italic> pili in acute pulmonary infection.","volume":"63","author":"H Tang","year":"1995","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00004630-199405000-00005","article-title":"A quantitative model of invasive <italic>Pseudomonas<\/italic> infection in burn injury.","volume":"15","author":"E Stevens","year":"1994","journal-title":"J Burn Care Rehabil"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes.","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucl Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/abbi.1994.1187","article-title":"Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes.","volume":"310","author":"R Kagan","year":"1994","journal-title":"Arch Biochem Biophy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0959-440X(02)00391-3","article-title":"SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold.","volume":"12","author":"J Martin","year":"2002","journal-title":"Curr Opin Stru Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1006\/jmbi.1993.1413","article-title":"Prediction of Protein Secondary Structure at Better than 70% Accuracy","volume":"232","author":"B Rost","year":"1993","journal-title":"J Mol Bio"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkj102","article-title":"From genomics to chemical genomics: new developments in KEGG.","volume":"34","author":"M Kanehisa","year":"2006","journal-title":"Nucl Acids Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.mi.38.100184.000405","article-title":"Metabolism of Methylglyoxal in Microorganisms.","volume":"38","author":"R Cooper","year":"1984","journal-title":"Ann Rev Micro"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1383-5718(00)00044-9","article-title":"Methylglyoxal induces G:C to C:G and G:C to T:A transversions in the supF gene on a shuttle vector plasmid replicated in mammalian cells.","volume":"468","author":"N Murata-Kamiya","year":"2000","journal-title":"Mut Res\/Gen Tox Env Mut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1073\/pnas.77.5.2450","article-title":"Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H.","volume":"77","author":"T Itoh","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1073\/pnas.81.4.1040","article-title":"RNase H Confers Specificity in the <italic>dnaA<\/italic>-Dependent Initiation of Replication at the Unique Origin of the <italic>Escherichia coli<\/italic> Chromosome <italic>in vivo<\/italic> and <italic>in vitro<\/italic>.","volume":"81","author":"T Ogawa","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1073\/pnas.81.11.3447","article-title":"The <italic>rnh<\/italic> gene is essential for growth of <italic>Escherichia coli<\/italic>.","volume":"81","author":"S Kanaya","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1093\/nar\/26.17.4005","article-title":"Mutational analysis of the 3\u2032--&gt;5\u2032 proofreading exonuclease of <italic>Escherichia coli<\/italic> DNA polymerase III.","volume":"26","author":"S Taft-Benz","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"14339","DOI":"10.1073\/pnas.2036282100","article-title":"Comprehensive transposon mutant library of <italic>Pseudomonas aeruginosa<\/italic>.","volume":"100","author":"M Jacobs","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","first-page":"37","article-title":"<italic>Vibrio cholerae<\/italic>: molecular pathogenesis, immune response, and vaccine development.","author":"M Waldor","year":"1996"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1073\/pnas.0803281105","article-title":"A defined transposon mutant library and its use in identifying motility genes in <italic>Vibrio cholerae<\/italic>.","volume":"105","author":"D Cameron","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1371\/journal.ppat.0010008","article-title":"<italic>Vibrio cholerae<\/italic> infection of <italic>Drosophila melanogaster<\/italic> mimics the human disease cholera.","volume":"1","author":"NS Blow","year":"2005","journal-title":"PLoS Path"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/MMBR.62.4.1315-1352.1998","article-title":"The virulence plasmid of <italic>Yersinia<\/italic>, an antihost genome.","volume":"62","author":"G Cornelis","year":"1998","journal-title":"Micro Mol Biol Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/IAI.37.2.506-512.1982","article-title":"Temperature-inducible outer membrane protein of <italic>Yersinia pseudotuberculosis<\/italic> and <italic>Yersinia enterocolitica<\/italic> is associated with the virulence plasmid.","volume":"37","author":"I Bolin","year":"1982","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0899-5885(18)30865-7","article-title":"Immunosuppression of the burned patient.","volume":"1","author":"EV Robins","year":"1989","journal-title":"Crit Care Nurs Clin North Am"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1021\/bi0022902","article-title":"Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.","volume":"40","author":"H Cai","year":"2001","journal-title":"Biochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1365-2958.2005.04990.x","article-title":"Metabolic regulation of type III secretion gene expression in <italic>Pseudomonas aeruginosa<\/italic>.","volume":"59","author":"A Rietsch","year":"2006","journal-title":"Mol Micro"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrmicro1350","article-title":"N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.","volume":"4","author":"D Wion","year":"2006","journal-title":"Nat Rev Micro"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(89)90359-4","article-title":"Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.","volume":"77","author":"R Horton","year":"1989","journal-title":"Gene"},{"key":"ref46","article-title":"A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked <italic>Pseudomonas aeruginosa<\/italic> mutants.","volume":"77-86","author":"T Hoang","year":"1998","journal-title":"Gene 212"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0928-8244(03)00181-0","article-title":"A rapid and simple method for inactivating chromosomal genes in <italic>Yersinia<\/italic>.","volume":"38","author":"A Derbise","year":"2003","journal-title":"FEMS Immu Med Micro"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1365-2958.2004.04448.x","article-title":"The contribution of MvfR to <italic>Pseudomonas aeruginosa<\/italic> pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting <italic>lasRI<\/italic>, <italic>rhlRI<\/italic> or the production of <italic>N<\/italic>-acyl- l-homoserine lactones.","volume":"55","author":"E D\u00e9ziel","year":"2005","journal-title":"Mol Micro"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:19:41Z","timestamp":1590153581000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007167"}},"subtitle":[],"editor":[{"given":"Christophe","family":"Herman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007167","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}