{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:52:26Z","timestamp":1726847546616},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T00:00:00Z","timestamp":1254182400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007217","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T22:39:13Z","timestamp":1254177553000},"page":"e7217","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Trypanosome Rab-Related Proteins RabX1 and RabX2 Play No Role in IntraCellular Trafficking but May Be Involved in Fly Infectivity"],"prefix":"10.1371","volume":"4","author":[{"given":"Senthil Kumar A.","family":"Natesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Fai","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith R.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Field","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","article-title":"The trypanosomiases.","volume":"362","author":"MP Barrett","year":"2003","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1128\/EC.00213-07","article-title":"Activation of endocytosis as an adaptation to the mammalian host by trypanosomes.","volume":"6","author":"SK Natesan","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0166-6851(97)00160-6","article-title":"Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture.","volume":"90","author":"B Reuner","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1242\/jcs.110.21.2661","article-title":"Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway.","volume":"110","author":"E Vassella","year":"1997","journal-title":"J Cell Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/jcs.01649","article-title":"The developmental cell biology of Trypanosoma brucei.","volume":"118","author":"KR Matthews","year":"2005","journal-title":"J Cell Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0248-4900(88)90070-6","article-title":"Biology of African trypanosomes in the tsetse fly.","volume":"64","author":"K Vickerman","year":"1988","journal-title":"Biol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0169-4758(99)01512-4","article-title":"Tsetse-trypanosome interactions: rites of passage.","volume":"15","author":"SC Welburn","year":"1999","journal-title":"Parasitol Today"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.exppara.2007.05.011","article-title":"Trypanosoma brucei 29\u201313 strain is inducible in but not permissive for the tsetse fly vector.","volume":"117","author":"S Herder","year":"2007","journal-title":"Exp Parasitol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4613-9044-2_6","article-title":"Transmission of African trypanosomiasis: Interactions among tsetse immune system, symbionts and parasties.","volume":"7","author":"I Maudlin","year":"1991","journal-title":"Advances in Disease Vector Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molbiopara.2008.04.009","article-title":"Fly transmission and mating of Trypanosoma brucei brucei strain 427.","volume":"160","author":"L Peacock","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1600-0854.2004.00234.x","article-title":"Intracellular membrane transport systems in Trypanosoma brucei.","volume":"5","author":"MC Field","year":"2004","journal-title":"Traffic"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1242\/jcs.114.14.2605","article-title":"Developmental and morphological regulation of clathrin-mediated endocytosis in Trypanosoma brucei.","volume":"114","author":"GW Morgan","year":"2001","journal-title":"J Cell Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1242\/jcs.37.1.287","article-title":"Capping of variable antigen on Trypanosoma brucei, and its immunological and biological significance.","volume":"37","author":"JD Barry","year":"1979","journal-title":"J Cell Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2007.08.046","article-title":"Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes.","volume":"131","author":"M Engstler","year":"2007","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1074\/jbc.M110055200","article-title":"Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway.","volume":"277","author":"A Pal","year":"2002","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1471-4922(02)02391-7","article-title":"The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences.","volume":"18","author":"GW Morgan","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S1471-4922(02)02392-9","article-title":"The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system.","volume":"18","author":"GW Morgan","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molbiopara.2005.01.017","article-title":"A bioinformatic analysis of the RAB genes of Trypanosoma brucei.","volume":"141","author":"JP Ackers","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pt.2005.08.008","article-title":"Signalling the genome: the Ras-like small GTPase family of trypanosomatids.","volume":"21","author":"MC Field","year":"2005","journal-title":"Trends Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.biocel.2008.08.041","article-title":"Evolution of specificity in the eukaryotic endomembrane system.","volume":"41","author":"JB Dacks","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1112642","article-title":"The genome of the African trypanosome Trypanosoma brucei.","volume":"309","author":"M Berriman","year":"2005","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/978-0-387-74021-8_7","article-title":"Reconstructing the evolution of the endocytic system: insights from genomics and molecular cell biology.","volume":"607","author":"MC Field","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molbiopara.2004.06.007","article-title":"TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei.","volume":"137","author":"V Dhir","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"32102","DOI":"10.1074\/jbc.273.48.32102","article-title":"Complexity of trypanosomatid endocytosis pathways revealed by Rab4 and Rab5 isoforms in Trypanosoma brucei.","volume":"273","author":"H Field","year":"1998","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1242\/jcs.114.14.2617","article-title":"A developmentally regulated rab11 homologue in Trypanosoma brucei is involved in recycling processes.","volume":"114","author":"TR Jeffries","year":"2001","journal-title":"J Cell Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0166-6851(02)00133-0","article-title":"Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite.","volume":"123","author":"PW Denny","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1471-4914(01)02227-4","article-title":"Rab GTPases, intracellular traffic and disease.","volume":"8","author":"MC Seabra","year":"2002","journal-title":"Trends Mol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1074\/jbc.272.16.10498","article-title":"Tandem duplication of rab genes followed by sequence divergence and acquisition of distinct functions in Trypanosoma brucei.","volume":"272","author":"H Field","year":"1997","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0166-6851(99)00192-9","article-title":"Cell-cycle and developmental regulation of TbRAB31 localisation, a GTP-locked Rab protein from Trypanosoma brucei.","volume":"106","author":"H Field","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"ref30","first-page":"289","article-title":"Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.","volume":"36","author":"R Brun","year":"1979","journal-title":"Acta Trop"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0169-4758(94)90402-2","article-title":"Axenic culture of African trypanosome bloodstream forms.","volume":"10","author":"H Hirumi","year":"1994","journal-title":"Parasitol Today"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0014-4894(76)90110-7","article-title":"Trypanosoma brucei: a rapid \u201cmatching\u201d method for estimating the host&apos;s parasitemia.","volume":"40","author":"WJ Herbert","year":"1976","journal-title":"Exp Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1371\/journal.pone.0000239","article-title":"Factors affecting trypanosome maturation in tsetse flies.","volume":"2","author":"ET Macleod","year":"2007","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0166-6851(03)00045-8","article-title":"RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei.","volume":"128","author":"S Redmond","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/nar\/gkf577","article-title":"Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements.","volume":"30","author":"Quijada","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0166-6851(93)90231-L","article-title":"Rapid isolation of DNA from trypanosomatid protozoa using a simple \u2018mini-prep\u2019 procedure.","volume":"59","author":"E Medina-Acosta","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"ref37","article-title":"Molecular Cloning, a Laboratory Manual.","author":"J Sambrook","year":"1989"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1017\/S1431927604040942","article-title":"New approaches to the microscopic imaging of Trypanosoma brucei.","volume":"10","author":"MC Field","year":"2004","journal-title":"Microsc Microanal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2818.2000.00704.x","article-title":"Immunocytochemical strategies for electron microscopy: choice or compromise.","volume":"199","author":"JN Skepper","year":"2000","journal-title":"J Microsc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1093\/emboj\/cdg481","article-title":"Clathrin-mediated endocytosis is essential in Trypanosoma brucei.","volume":"22","author":"CL Allen","year":"2003","journal-title":"EMBO J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1242\/jcs.112.2.147","article-title":"TbRab2p, a marker for the endoplasmic reticulum of Trypanosoma brucei, localises to the ERGIC in mammalian cells.","volume":"112 (Pt 2)","author":"H Field","year":"1999","journal-title":"J Cell Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pt.2008.03.005","article-title":"How complex is GTPase signaling in trypanosomes?","volume":"24","author":"MC Field","year":"2008","journal-title":"Trends Parasitol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molbiopara.2004.07.007","article-title":"Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis.","volume":"138","author":"B Hall","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature07997","article-title":"A surface transporter family conveys the trypanosome differentiation signal.","volume":"459","author":"S Dean","year":"2009","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/BF00931012","article-title":"Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei.","volume":"77","author":"D Schell","year":"1991","journal-title":"Parasitol Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1083\/jcb.131.5.1173","article-title":"Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei.","volume":"131","author":"D Steverding","year":"1995","journal-title":"J Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"45047","DOI":"10.1074\/jbc.M407271200","article-title":"Rab4 is an essential regulator of lysosomal trafficking in trypanosomes.","volume":"279","author":"BS Hall","year":"2004","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1128\/EC.4.5.971-980.2005","article-title":"Developmental variation in Rab11-dependent trafficking in Trypanosoma brucei.","volume":"4","author":"BS Hall","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/expr.1995.1122","article-title":"Trypanosoma brucei: molecular cloning of homologues of small GTP-binding proteins involved in vesicle trafficking.","volume":"81","author":"MC Field","year":"1995","journal-title":"Exp Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1365-2958.2005.04679.x","article-title":"Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.","volume":"57","author":"EF Hendriks","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1242\/jcs.115.16.3253","article-title":"Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei.","volume":"115","author":"DL Alexander","year":"2002","journal-title":"J Cell Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"18387","DOI":"10.1074\/jbc.271.31.18387","article-title":"A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting.","volume":"271","author":"JD Bangs","year":"1996","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/jcs.105.4.1101","article-title":"Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote.","volume":"105 (Pt 4)","author":"JD Bangs","year":"1993","journal-title":"J Cell Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/EC.2.1.76-83.2003","article-title":"Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei.","volume":"2","author":"VP Triggs","year":"2003","journal-title":"Eukaryot Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1083\/jcb.200605090","article-title":"Protein tyrosine phosphatase TbPTP1: A molecular switch controlling life cycle differentiation in trypanosomes.","volume":"175","author":"B Szoor","year":"2006","journal-title":"J Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T11:11:28Z","timestamp":1633950688000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007217"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Callaerts","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,9,29]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007217","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,29]]}}}