{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:44:01Z","timestamp":1790297041136,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:00:00Z","timestamp":1254787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007297","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T22:24:01Z","timestamp":1254781441000},"page":"e7297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Is There a Link between the Lipopolysaccharide of Helicobacter pylori Gastric MALT Lymphoma Associated Strains and Lymphoma Pathogenesis?"],"prefix":"10.1371","volume":"4","author":[{"given":"Philippe","family":"Lehours","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"M\u00e9graud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Engstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,10,6]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Schistosomes, liver flukes and <italic>Helicobacter pylori<\/italic>. in \u201cMonographs on the evaluation of carcinogenic risks to humans\u201d IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.","volume":"61","year":"1994"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1073\/pnas.96.22.12778","article-title":"Clinical relevance of the <italic>Helicobacter pylori<\/italic> gene for blood-group antigen-binding adhesin.","volume":"96","author":"M Gerhard","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/mp.56.1.36","article-title":"<italic>Helicobacter pylori<\/italic> genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues.","volume":"56","author":"CI Koehler","year":"2003","journal-title":"Mol Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/IAI.72.2.880-888.2004","article-title":"Evaluation of the association of nine <italic>Helicobacter pylori<\/italic> virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma.","volume":"72","author":"P Lehours","year":"2004","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/gut.2003.028811","article-title":"Identification of a genetic marker of <italic>Helicobacter pylori<\/italic> strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type.","volume":"53","author":"P Lehours","year":"2004","journal-title":"Gut"},{"key":"ref6","first-page":"54","article-title":"<italic>Helicobacter pylori<\/italic> infection and gastric MALT lymphoma.","volume":"50","author":"P Lehours","year":"2005","journal-title":"Rocz Akad Med Bialymst"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2796.2009.02083.x","article-title":"Infectious agents and lymphoma development: molecular and clinical aspects.","volume":"265","author":"AJ Ferreri","year":"2009","journal-title":"J Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0140-6736(93)91408-E","article-title":"The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to <italic>Helicobacter pylori<\/italic>.","volume":"342","author":"T Hussell","year":"1993","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","article-title":"T helper 1 effector cells specific for <italic>Helicobacter pylori<\/italic> in the gastric antrum of patients with peptic ulcer disease.","volume":"158","author":"MM D'Elios","year":"1997","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0016-5085(99)70395-1","article-title":"Impaired T-cell regulation of B-cell growth in <italic>Helicobacter pylori<\/italic>-related gastric low-grade MALT lymphoma.","volume":"117","author":"MM D'Elios","year":"1999","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.coi.2008.09.007","article-title":"Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance.","volume":"20","author":"M Rescigno","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20041061","article-title":"<italic>Helicobacter pylori<\/italic> modulates the T helper cell 1\/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.","volume":"200","author":"MP Bergman","year":"2004","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1182\/blood-2005-09-3679","article-title":"Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation.","volume":"107","author":"F Suarez","year":"2006","journal-title":"Blood"},{"key":"ref14","first-page":"S259","article-title":"<italic>Helicobacter pylori<\/italic> LPS: molecular mimicry with the host and role in autoimmunity.","volume":"30","author":"CM Vandenbroucke-Grauls","year":"1998","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"ref15","first-page":"919","article-title":"Lewis blood group-related antigen expression in normal gastric epithelium, intestinal metaplasia, gastric adenoma, and gastric carcinoma.","volume":"88","author":"K Kobayashi","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1074\/jbc.273.19.11533","article-title":"Simultaneous expression of type 1 and type 2 Lewis blood group antigens by <italic>Helicobacter pylori<\/italic> lipopolysaccharides.","volume":"273","author":"MA Monteiro","year":"1998","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/IAI.68.2.937-941.2000","article-title":"Relationship of blood group determinants on <italic>Helicobacter pylori<\/italic> lipopolysaccharide with host Lewis phenotype and inflammatory response.","volume":"68","author":"MA Heneghan","year":"2000","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.0511119103","article-title":"An enzymatic ruler modulates Lewis antigen glycosylation of <italic>Helicobacter pylori<\/italic> LPS during persistent infection.","volume":"103","author":"C Nilsson","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.carres.2007.12.012","article-title":"Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen <italic>Helicobacter pylori<\/italic>.","volume":"343","author":"AP Moran","year":"2008","journal-title":"Carbohydr Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1574-6968.2000.tb09264.x","article-title":"Comparison of three serological methods for detection of Lewis antigens on the surface of <italic>Helicobacter pylori<\/italic>.","volume":"190","author":"SO Hynes","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/IAI.64.11.4598-4605.1996","article-title":"Expression of the human cell surface glycoconjugates Lewis x and Lewis y by <italic>Helicobacter pylori<\/italic> isolates is related to <italic>cag<\/italic>A status.","volume":"64","author":"HP Wirth","year":"1996","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1574-695X.1999.tb01268.x","article-title":"Lack of a relationship between Lewis antigen expression and <italic>cag<\/italic>A, CagA, <italic>vac<\/italic>A and VacA status of Irish <italic>Helicobacter pylori isolates<\/italic>.","volume":"24","author":"DG Marshall","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1128\/JCM.02370-07","article-title":"Lewis antigen expression by <italic>Helicobacter pylori<\/italic> strains colonizing different regions of the stomach of individual patients.","volume":"46","author":"G Gonzalez-Valencia","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/339016","article-title":"Lewis antigen expression and other pathogenic factors in the presence of atrophic chronic gastritis in a European population.","volume":"185","author":"N Broutet","year":"2002","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e5885","DOI":"10.1371\/journal.pone.0005885","article-title":"A changing gastric environment leads to adaptation of lipopolysaccharide variants in <italic>Helicobacter pylori<\/italic> populations during colonization.","volume":"4","author":"A Skoglund","year":"2009","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1523-5378.2007.00546.x","article-title":"In Vitro Proinflammatory Properties of <italic>Helicobacter pylori<\/italic> Strains Causing Low-Grade Gastric MALT Lymphoma.","volume":"12","author":"B Ferreira-Chagas","year":"2007","journal-title":"Helicobacter"},{"key":"ref27","first-page":"787","article-title":"<italic>Helicobacter pylori<\/italic> lipopolysaccharide-mediated gastric and extragastric pathology.","volume":"50","author":"AP Moran","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1046\/j.1365-2958.1999.01268.x","article-title":"Molecular genetic basis for the variable expression of Lewis Y antigen in <italic>Helicobacter pylori<\/italic>: analysis of the alpha (1,2) fucosyltransferase gene.","volume":"31","author":"G Wang","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1046\/j.1365-2958.2000.01934.x","article-title":"Lewis antigens in <italic>Helicobacter pylori<\/italic>: biosynthesis and phase variation.","volume":"36","author":"G Wang","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1073\/pnas.242741699","article-title":"Distinct gene expression profiles characterize the histopathological stages of disease in <italic>Helicobacter<\/italic>-induced mucosa-associated lymphoid tissue lymphoma.","volume":"100","author":"A Mueller","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1111\/j.1440-1746.2008.05553.x","article-title":"Gene expression profiling in Helicobacter-induced MALT lymphoma with reference to antigen drive and protective immunization.","volume":"23","author":"JL O'Rourke","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"ref32","first-page":"1583","article-title":"Low-grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT-type) require CD4O-mediated signaling and Th2-type cytokines for <italic>in vitro<\/italic> growth and differentiation.","volume":"150","author":"A Greiner","year":"1997","journal-title":"Am J Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/labinvest.3700056","article-title":"Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by <italic>Helicobacter pylori<\/italic> infection in neonatally thymectomized mice.","volume":"84","author":"T Fukui","year":"2004","journal-title":"Lab Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/00365520410008141","article-title":"Valid symptom reporting at upper endoscopy in a random sample of the Swedish adult general population: the Kalixanda study.","volume":"39","author":"P Aro","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e3811","DOI":"10.1371\/journal.pone.0003811","article-title":"Lipopolysaccharide diversity evolving in <italic>Helicobacter pylori<\/italic> communities through genetic modifications in fucosyltransferases.","volume":"3","author":"C Nilsson","year":"2008","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","article-title":"Mosaicism in vacuolating cytotoxin alleles of <italic>Helicobacter pylori<\/italic> - Association of specific <italic>vac<\/italic>A types with cytotoxin production and peptic ulceration.","volume":"270","author":"JC Atherton","year":"1995","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T01:51:20Z","timestamp":1685152280000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007297"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Bereswill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,10,6]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007297","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,6]]}}}