{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:40:27Z","timestamp":1791852027587,"version":"4.3.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T00:00:00Z","timestamp":1257465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007723","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T23:50:04Z","timestamp":1257465004000},"page":"e7723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["Penicillin Induced Persistence in Chlamydia trachomatis: High Quality Time Lapse Video Analysis of the Developmental Cycle"],"prefix":"10.1371","volume":"4","author":[{"given":"Rachel J.","family":"Skilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley T.","family":"Cutcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Barlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Lambden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian N.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,11,6]]},"reference":[{"key":"ref1","first-page":"55","article-title":"The epidemiology of trachoma predicts more blindness in the future.","volume":"69","author":"J Schachter","year":"1990","journal-title":"Scandinavian Journal of Infectious Disease"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0140-6736(98)90001-0","article-title":"Global epidemiology of sexually transmitted diseases.","volume":"351","author":"AC Gerbase","year":"1998","journal-title":"Lancet"},{"key":"ref3","first-page":"403","article-title":"The chlamydial developmental cycle.","author":"DD Rockey","year":"2000"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/oxfordjournals.bmb.a071800","article-title":"Chlamydial classification, development and structure.","volume":"39","author":"ME Ward","year":"1983","journal-title":"Br Med Bull"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1073\/pnas.92.11.4877","article-title":"Lipid metabolism in <italic>Chlamydia trachomatis-<\/italic>infected cells: directed trafficking of Golgi-derived sphingolipids to the Chlamydial inclusion.","volume":"92","author":"T Hackstadt","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.cellbio.18.012502.105845","article-title":"The Chlamydial Inclusion: Escape from the endocytic pathway.","volume":"18","author":"KA Fields","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1128\/IAI.64.12.5366-5372.1996","article-title":"Vesicular interactions of the <italic>Chlamydia trachomatis<\/italic> inclusion are determined by Chlamydial early protein synthesis rather than route of entry.","volume":"64","author":"MA Scidmore","year":"1996","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1128\/IAI.59.8.2624-2630.1991","article-title":"Neutralization of Chlamydia trachomatis: Kinetics and Stoichiometry.","volume":"59","author":"RW Peeling","year":"1991","journal-title":"Infect Immun"},{"key":"ref9","first-page":"29","article-title":"Developmental Biology.","author":"TP Hatch","year":"1999"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1099\/mic.0.27625-0","article-title":"The plasmids of <italic>Chlamydia trachomatis<\/italic> and <italic>Chlamydophila pneumoniae<\/italic> (N16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents.","volume":"151","author":"MA Pickett","year":"2005","journal-title":"Microbiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1099\/mic.0.29032-0","article-title":"The effect of penicillin on Chlamydia trachomatis DNA replication.","volume":"152","author":"PR Lambden","year":"2006","journal-title":"Microbiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bulm.2003.09.001","article-title":"Use of a quantitative gene expression assay based on micro-array techniques and a mathematical model for the investigation of chlamydial generation time.","volume":"66","author":"DP Wilson","year":"2004","journal-title":"Bull Math Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/JB.151.1.420-428.1982","article-title":"<italic>Chlamydia trachomatis<\/italic> has penicillin-binding proteins but not detectable muramic acid.","volume":"151","author":"AG Barbour","year":"1982","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/AAC.45.1.303-305.2001","article-title":"Affinities of beta-lactams for penicillin binding proteins of <italic>Chlamydia trachomatis<\/italic> and their antichlamydial activities.","volume":"45","author":"C Storey","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.282.5389.754","article-title":"Genome sequence of an obligate intracellular pathogen of humans: <italic>Chlamydia trachomatis<\/italic>.","volume":"282","author":"RS Stephens","year":"1998","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1101\/gr.7020108","article-title":"Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates.","volume":"18","author":"NR Thomson","year":"2008","journal-title":"Genome Res"},{"key":"ref17","first-page":"87","article-title":"Why is <italic>Chlamydia<\/italic> sensitive to penicillin in the absence of peptidoglycan?","volume":"2","author":"JW Moulder","year":"1993","journal-title":"Infect Agents Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1099\/00221287-144-10-2673","article-title":"Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisited.","volume":"144","author":"I Chopra","year":"1998","journal-title":"Microbiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tim.2005.12.004","article-title":"Building the invisible wall: updating the chlamydial peptidoglycan anomaly.","volume":"14","author":"AJ McCoy","year":"2006","journal-title":"Trends Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tim.2007.02.003","article-title":"Another brick in the wall.","volume":"15","author":"MS Pavelka","year":"2007","journal-title":"Trends Microbiol"},{"key":"ref21","first-page":"2001","article-title":"Fine Structure of Lymphogranuloma Venereum Agent and the Effects of Penicillin and 5\u2032 Fluorouracil.","volume":"129","author":"JA Armstrong","year":"1967","journal-title":"J Gen Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1128\/JB.101.1.278-285.1970","article-title":"Electron microscopic observations on the effects of penicillin on the morphology of <italic>Chlamydia psittaci<\/italic>.","volume":"101","author":"A Matsumoto","year":"1970","journal-title":"J Bacteriol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/IAI.3.2.333-341.1971","article-title":"Ultra structural analysis of the effects of penicillin and chlortetracycline on the development of genital tract <italic>Chlamydia<\/italic>.","volume":"3","author":"MJ Kramer","year":"1971","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jac\/3.1.49","article-title":"The effect of penicillin on genital strains of <italic>Chlamydia trachomatis<\/italic> in tissue culture.","volume":"3","author":"FWA Johnson","year":"1977","journal-title":"J Antimicrob Chemother"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-5320(84)90122-9","article-title":"Ultrastructure of <italic>Chlamydia trachomatis<\/italic> infection of the mouse oviduct.","volume":"88","author":"DM Phillips","year":"1984","journal-title":"J Ultrastruct Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02123623","article-title":"Ultrastructural effect of penicillin and cycloheximide on <italic>Chlamydia trachomatis<\/italic> strain HAR-13.","volume":"171","author":"RB Clark","year":"1982","journal-title":"Med Microbiology Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1099\/mic.0.28658-0","article-title":"A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture.","volume":"152","author":"CM O'Connell","year":"2006","journal-title":"Microbiology-Sgm"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1128\/JB.00293-09","article-title":"Kinematics of Intracellular Chlamydiae Provide Evidence for Contact-Dependent Development.","volume":"191","author":"DP Wilson","year":"2009","journal-title":"J Bacteriol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/MMBR.58.4.686-699.1994","article-title":"Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis.","volume":"58","author":"WL Beatty","year":"1994","journal-title":"Microbiol Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.72.4.1843-1855.2004","article-title":"Chlamydial persistence: beyond the biphasic paradigm.","volume":"72","author":"RJ Hogan","year":"2004","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/pmic.200401044","article-title":"Shotgun proteomic analysis of <italic>Chlamydia trachomatis<\/italic>.","volume":"5","author":"P Skipp","year":"2005","journal-title":"Proteomics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1128\/JB.00235-07","article-title":"Intracellular parasitism of chlamydiae: specific infectivity of chlamydiaphage Chp2 in Chlamydophila abortus.","volume":"189","author":"RJ Skilton","year":"2007","journal-title":"J Bacteriol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1128\/JVI.74.8.3464-3469.2000","article-title":"Molecular characterization of a bacteriophage (Chp2) from <italic>Chlamydia psittaci<\/italic>.","volume":"74","author":"BL Liu","year":"2000","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T13:19:59Z","timestamp":1590239999000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007723"}},"subtitle":[],"editor":[{"given":"Kathleen A.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,11,6]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007723","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,6]]}}}