{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:52:45Z","timestamp":1793379165465,"version":"4.5.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T00:00:00Z","timestamp":1257379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007729","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T15:53:35Z","timestamp":1257350015000},"page":"e7729","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":91,"title":["Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease"],"prefix":"10.1371","volume":"4","author":[{"given":"Klaus","family":"Stark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Grassl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Erdmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Illig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","article-title":"Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study.","volume":"82","author":"EW Campion","year":"1987","journal-title":"Am J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1371\/journal.pgen.0030194","article-title":"The <italic>GLUT9<\/italic> Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts.","volume":"3","author":"S Li","year":"2007","journal-title":"PLoS Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e1948","DOI":"10.1371\/journal.pone.0001948","article-title":"Association of common polymorphisms in <italic>GLUT9<\/italic> gene with gout but not with coronary artery disease in a large case-control study.","volume":"3","author":"K Stark","year":"2008","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.107","article-title":"SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.","volume":"40","author":"A D\u00f6ring","year":"2008","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.","volume":"40","author":"V Vitart","year":"2008","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.","volume":"372","author":"A Dehghan","year":"2008","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1000504","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.","volume":"5","author":"M Kolz","year":"2009","journal-title":"PLoS Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study.","volume":"131","author":"BF Culleton","year":"1999","journal-title":"Ann Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1001\/jama.283.18.2404","article-title":"Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971\u20131992. National Health and Nutrition Examination Survey.","volume":"283","author":"J Fang","year":"2000","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1001\/archinte.164.14.1546","article-title":"Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study.","volume":"164","author":"LK Niskanen","year":"2004","journal-title":"Arch Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng.307","article-title":"New susceptibility locus for coronary artery disease on chromosome 3q22.3.","volume":"41","author":"J Erdmann","year":"2009","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease.","volume":"357","author":"NJ Samani","year":"2007","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies.","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"26834","DOI":"10.1074\/jbc.C800156200","article-title":"Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.","volume":"283","author":"N Anzai","year":"2008","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1371\/journal.pmed.0050197","article-title":"SLC2A9 is a high-capacity urate transporter in humans.","volume":"5","author":"MJ Caulfield","year":"2008","journal-title":"PLoS Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2008.11.001","article-title":"Mutations in glucose transporter 9 gene <italic>SLC2A9<\/italic> cause renal hypouricemia.","volume":"83","author":"H Matsuo","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/aje\/kwg150","article-title":"Searching for disease-susceptibility loci by testing for Hardy-Weinberg disequilibrium in a gene bank of affected individuals.","volume":"158","author":"WC Lee","year":"2003","journal-title":"Am J Epidemiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00439-002-0819-y","article-title":"Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?","volume":"111","author":"J Xu","year":"2002","journal-title":"Hum Genet"},{"key":"ref21","article-title":"Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005.","volume":"(2007)","author":"L Annemans","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.3949\/ccjm.75.Suppl_5.S5","article-title":"Clinical manifestations of hyperuricemia and gout.","volume":"75","author":"BF Mandell","year":"2008","journal-title":"Cleve Clin J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels.","volume":"417","author":"A Enomoto","year":"2002","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0895-4356(88)90127-8","article-title":"Gout and coronary heart disease: the Framingham Study.","volume":"41","author":"RD Abbott","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.amjmed.2005.03.043","article-title":"Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?","volume":"118","author":"JF Baker","year":"2005","journal-title":"Am J Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.107.703389","article-title":"Independent impact of gout on mortality and risk for coronary heart disease.","volume":"116","author":"HK Choi","year":"2007","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2458-4-9","article-title":"Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country.","volume":"4","author":"D Conen","year":"2004","journal-title":"BMC Public Health"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk.","volume":"359","author":"DI Feig","year":"2008","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","article-title":"A common variant on chromosome 9p21 affects the risk of myocardial infarction.","volume":"316","author":"A Helgadottir","year":"2007","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","article-title":"A common allele on chromosome 9 associated with coronary heart disease.","volume":"316","author":"R McPherson","year":"2007","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ng.314","article-title":"Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.","volume":"41","author":"DA Tregouet","year":"2009","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T12:14:58Z","timestamp":1558613698000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007729"}},"subtitle":[],"editor":[{"given":"Jeffrey S.","family":"Berger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,11,5]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007729","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,5]]}}}